Diclofenac Sodium BP

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Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) widely used for its potent analgesic, anti-inflammatory, and antipyretic properties. It is the sodium salt form of diclofenac, providing enhanced solubility and rapid absorption. Diclofenac Sodium BP (British Pharmacopoeia standard) ensures pharmaceutical-grade purity and compliance with stringent quality standards. It is commonly formulated in oral tablets, topical gels, injections, and ophthalmic preparations.

Description

Diclofenac Sodium BP Uses

Primary Uses 

  1. Medical & Pharmaceutical Applications

  • Pain Relief: Effective in managing acute and chronic pain, including musculoskeletal pain, postoperative pain, and dental pain.

  • Anti-inflammatory Treatment: Used in inflammatory conditions such as rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, and gout.

  • Antipyretic: Reduces fever associated with infections or inflammatory diseases.

  • Ophthalmic Use: Formulated in eye drops for postoperative inflammation and ocular pain relief.

  • Topical Application: Used in gels, creams, and patches for localized relief of muscle pain, sprains, and strains.

  • Injection Form: Employed in hospital settings for rapid relief of severe pain and inflammation.

  1. Veterinary Medicine

  • Used for analgesia and inflammation control in animals, especially in equine and companion animals for musculoskeletal injuries and post-surgical pain.

 

Secondary Uses 

  1. Sports Medicine

  • Widely used among athletes for rapid treatment of sports injuries such as tendonitis, bursitis, and ligament strains.

  1. Dentistry

  • Prescribed to reduce pain and inflammation post-dental surgery and procedures like tooth extractions or root canals.

  1. Postoperative Care

  • Administered to manage pain and inflammation after orthopedic, gynecological, and other surgical procedures.

  1. Migraine and Headache Treatment

  • Employed as part of acute migraine treatment regimens to alleviate pain and associated symptoms.

  1. Combination Formulations

  • Often combined with other analgesics, muscle relaxants, or gastroprotective agents for synergistic effects and reduced side effects.
PRODUCT KEY FEATURES
  1. Basic Identification Attributes

  • Chemical Name (IUPAC): Sodium 2-[(2,6-dichlorophenyl)amino]benzeneacetate

  • Common/Trade Name: Diclofenac Sodium

  • CAS Number: 15307-86-5

  • HS Code: 2933.72.00

  • Molecular Formula: C14H10Cl2NNaO2

  • Synonyms:

    • Diclofenac Sodium BP

    • Sodium diclofenac

    • 2-(2,6-Dichloroanilino)phenylacetic acid sodium salt

  1. Physical & Chemical Properties

  • Physical State: White to off-white crystalline powder

  • Solubility: Freely soluble in water and polar solvents

  • Melting Point: Approximately 280°C (decomposes)

  • Stability: Stable under recommended storage conditions

  1. Safety & Hazard Attributes

  • Hazard Class (GHS): Harmful if swallowed; may cause gastrointestinal irritation

  • Toxicity: Low acute toxicity; contraindicated in certain patients due to risk of cardiovascular and gastrointestinal effects

  • Exposure Limits: Use as per pharmaceutical guidelines

  1. Storage & Handling Attributes

  • Storage Conditions: Store in a cool, dry place protected from light and moisture

  • Container Type: Airtight containers, blister packs, or HDPE bottles

  • Shelf Life: Typically 2–3 years if stored properly

  1. Regulatory & Compliance Attributes

  • Regulatory Status: Approved by major pharmacopeias (BP, USP, EP) for medicinal use

  • Transportation: Non-hazardous under normal pharmaceutical transport guidelines

  1. Environmental & Health Impact

  • Biodegradability: Moderate; environmental persistence under study

Ecotoxicity: Potential environmental pollutant; disposal should follow regulations

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

  • Use appropriate PPE including gloves and masks when handling raw powder.

  • Avoid inhalation and direct skin contact.

  • Follow pharmaceutical manufacturing GMP guidelines.

 

First Aid Measures

  • Inhalation: Move to fresh air, seek medical attention if symptoms occur.

  • Skin Contact: Wash thoroughly with soap and water.

  • Eye Contact: Rinse immediately with water for 15 minutes and seek medical care.

  • Ingestion: Medical attention required; do not induce vomiting.

 

Firefighting Measures

  • Fire Hazards: Combustible under high temperature

  • Extinguishing Media: Water spray, foam, dry chemical powder, COâ‚‚

Special Precautions: Avoid inhalation of combustion fumes