Disodium Hydrogen Phosphate
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Disodium Hydrogen Phosphate, also known as sodium phosphate dibasic, is an inorganic salt widely used as a buffering agent, emulsifier, and food additive. It appears as a white, odorless crystalline powder or granules that are highly soluble in water and alkaline in nature. It plays a crucial role in maintaining pH balance, stabilizing formulations, and supplying essential sodium and phosphate ions in various industries including food, pharmaceuticals, water treatment, and agriculture.
Disodium Hydrogen Phosphate
Primary Uses
- Food & Beverage Industry
- Acts as a buffering and pH control agent in processed foods, dairy products (like cheese and powdered milk), and beverages.
- Used as an emulsifier and sequestrant to improve texture, moisture retention, and shelf life.
- Serves as a leavening agent component in baking powders.
- Employed as a stabilizer in meat and seafood products to improve water retention and reduce spoilage.
- Added to nutritional supplements as a source of phosphate and sodium.Pharmaceuticals & Healthcare
- Used as a buffering agent in intravenous fluids, oral rehydration solutions, and pharmaceutical formulations to maintain pH stability.
- Functions as an excipient in tablets and capsules to control release rates.
- Utilized in parenteral nutrition solutions to supply electrolytes.Water Treatment
- Used to control pH and prevent scale formation and corrosion in industrial water treatment and boiler systems.
- Acts as a dispersing agent to keep suspended solids evenly distributed in water.Agriculture & Fertilizers
- Supplies phosphorus and sodium in fertilizer blends for soil amendment.
- Used in hydroponic nutrient solutions for plant growth enhancement.Industrial Applications
- Used in detergents and cleaning agents as a builder and pH stabilizer.
- Employed in ceramics, textile, and paper industries as a buffering and dispersing agent.
Secondary Uses
- Laboratory Reagent
- Commonly used in buffer preparations for biochemical and molecular biology research.
- Helps maintain consistent pH in enzyme reactions and protein purification processes.Cosmetics
- Used as a pH adjuster and buffering agent in creams, lotions, and personal care products.Animal Feed
- Included in feed supplements to provide phosphate and sodium for metabolic processes.
1. Basic Identification Attributes
- Chemical Name (IUPAC): Disodium hydrogen phosphate
- Common/Trade Name: Disodium Phosphate, Sodium Phosphate Dibasic
- CAS Number: 7558-79-4
- HS Code: 2835.25.00
- Molecular Formula: Na₂HPO₄·xH₂O (anhydrous or hydrated forms)
- Synonyms:
- Disodium phosphate
- Sodium phosphate dibasic
- Sodium hydrogen phosphate
2. Physical & Chemical Properties
- Physical State: White crystalline powder or granules
- Odor: Odorless
- Melting Point: Decomposes before melting (~100–200°C, depending on hydration)
- Solubility: Highly soluble in water; insoluble in alcohol
- pH (1% aqueous solution): Approximately 9.0–10.5 (alkaline)
- Stability: Stable under normal storage conditions; hygroscopic
3. Safety & Hazard Attributes
- Hazard Class (GHS): Not classified as hazardous
- Toxicity: Low toxicity; generally regarded as safe (GRAS) for food use
- Exposure Limits: No specific occupational exposure limits established
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place; protect from moisture
- Container Type: Paper bags with polyethylene lining, plastic drums
- Shelf Life: Typically 2–3 years if stored properly
- Handling Precautions: Avoid dust inhalation; use PPE to prevent eye and skin contact
5. Regulatory & Compliance Attributes
- Approved as food additive and pharmaceutical excipient worldwide
- Listed in USP, EP, FCC (Food Chemicals Codex)
- Compliant with REACH and other chemical regulations
6. Environmental & Health Impact
- Ecotoxicity: Low environmental toxicity
- Persistence: Biodegradable and non-persistent
- Bioaccumulation: Not expected
- Carcinogenicity/Mutagenicity: Not classified
Safety Handling Precautions
PPE Required:
- Dust mask or respirator (for dust exposure)
- Safety goggles
- Gloves (nitrile or latex)
- Protective lab coat or apron
Handling Guidelines:
- Handle in well-ventilated areas
- Avoid inhalation of dust and contact with skin or eyes
- Employ dust suppression methods during bulk transfer
Storage Measures:
- Keep container tightly sealed to avoid moisture absorption
- Store away from incompatible materials such as strong acids
- Avoid exposure to high humidity
Hygiene Practices:
- Wash hands after handling
- Do not eat, drink, or smoke while handling
- Maintain a clean work environment to prevent contamination
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if respiratory irritation or discomfort occurs
- Skin Contact: Wash thoroughly with soap and water; seek medical advice if irritation develops
- Eye Contact: Rinse immediately with plenty of water for at least 15 minutes; consult a physician if irritation persists
- Ingestion: Rinse mouth; generally low toxicity but seek medical advice if large amounts ingested
Firefighting Measures
- Fire Hazards: Non-flammable and non-combustible
- Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ to extinguish surrounding fire
- Special Precautions: Use standard firefighting protective equipment
- Decomposition Products: May form sodium oxides and phosphorus oxides at very high temperatures
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Disodium Hydrogen Phosphate Dihydrate is the hydrated form of disodium hydrogen phosphate, a white crystalline powder commonly used as a buffering agent, emulsifier, and sequestrant. The dihydrate form contains two water molecules per formula unit, which affects its physical properties such as melting point and solubility. It is widely applied in food, pharmaceutical, water treatment, and industrial processes to maintain pH stability, improve texture, and supply essential sodium and phosphate ions.
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