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HPMC Vivapharm E50
HPMC Vivapharm is a high-quality, pharmaceutical-grade hydroxypropyl methylcellulose polymer widely used as an excipient and functional ingredient. It appears as a fine, white to off-white, odorless powder with excellent solubility in cold water and forms clear, viscous solutions. This cellulose ether derivative offers excellent film-forming, thickening, emulsifying, and controlled-release properties. Vivapharm E50 is prized in pharmaceutical, food, and cosmetic industries for its versatility, stability, and safety profile.
HPMC Vivapharm E50
Primary Uses
- Pharmaceutical Industry
- Used as a tablet binder and film former in oral solid dosage forms to improve tablet integrity and controlled drug release.
- Acts as a matrix former in sustained-release formulations, providing controlled dissolution profiles for active pharmaceutical ingredients.
- Functions as a disintegrant or swellable excipient to facilitate tablet disintegration where required.
- Utilized as a suspending agent and viscosity enhancer in liquid oral formulations and ophthalmic preparations.
- Serves as a protective coating agent for tablets and capsules to mask taste and improve stability.
- Food Industry
- Employed as a thickener, stabilizer, and emulsifier in sauces, dressings, bakery products, and dairy alternatives.
- Used as a gluten substitute or additive in gluten-free baked goods to improve texture and moisture retention.
- Enhances mouthfeel and shelf-life in low-fat and reduced-calorie food formulations.
- Cosmetics and Personal Care
- Functions as a thickening agent and film former in lotions, creams, shampoos, and conditioners.
- Provides stabilization in emulsions and suspensions, preventing ingredient separation.
- Used in hair gels and styling products for desired viscosity and texture.
- Industrial Applications
- Acts as a rheology modifier in paints, adhesives, and printing inks to control flow properties.
- Used in construction materials such as tile adhesives and cementitious coatings to improve workability and water retention.
Secondary Uses
- Biomedical Research
- Used as a hydrogel base for drug delivery and tissue engineering studies.
- Employed in cell culture media as a viscosity modifier.
- Agriculture
- Utilized as a carrier or binder in pesticide formulations to improve adhesion and controlled release.
- Packaging
- Incorporated into biodegradable films and edible coatings for food packaging applications.
1. Basic Identification Attributes
- Chemical Name (IUPAC): Hydroxypropyl methylcellulose
- Common/Trade Name: HPMC Vivapharm E50
- CAS Number: 9004-65-3
- HS Code: 3912.90.00
- Molecular Formula: C56H108O30 (approximate polymer unit)
- Synonyms: Hypromellose; Methylhydroxypropyl cellulose; Methocel E50
2. Physical & Chemical Properties
- Physical State: Fine powder
- Color & Odor: White to off-white; odorless
- Viscosity (2% aqueous solution): ~50 mPa·s at 20°C
- Solubility: Soluble in cold water, insoluble in hot water and organic solvents
- pH (1% solution): Neutral to slightly alkaline (6.5–8.5)
- Thermal Stability: Stable up to ~200°C
- Film-Forming Ability: Excellent, clear films upon drying
3. Safety & Hazard Attributes
- GHS Classification: Non-hazardous; Generally Recognized As Safe (GRAS)
- Toxicity: Non-toxic and non-irritant at typical use levels
- Exposure Limits: No specific occupational exposure limits
4. Storage & Handling Attributes
- Container Type: Sealed polyethylene bags or drums with moisture barrier
- Storage Conditions: Store in cool, dry place away from moisture and direct sunlight
- Shelf Life: Up to 36 months if stored properly
- Handling Notes: Avoid dust generation; use dust masks in bulk handling
5. Regulatory & Compliance Attributes
- Approved for pharmaceutical use by USP, EP, JP
- Food additive status approved by FDA (E464) and EFSA
- Complies with REACH and other global chemical regulations
6. Environmental & Health Impact
- Biodegradability: Biodegradable under aerobic conditions
- Ecotoxicity: Low environmental toxicity
- Bioaccumulation: Not expected to bioaccumulate
- Carcinogenicity/Mutagenicity: Not classified
Safety Handling Precautions
- PPE Required: Dust mask, gloves, and safety goggles recommended during powder handling
- Handling Guidelines: Use in well-ventilated areas; avoid dust accumulation
- Hygiene Practices: Wash hands after handling; avoid inhalation of dust
First Aid Measures
- Inhalation: Move to fresh air if respiratory irritation occurs
- Skin Contact: Wash with soap and water if irritation develops
- Eye Contact: Rinse thoroughly with water for 15 minutes; seek medical advice if irritation persists
- Ingestion: Generally regarded as safe; seek medical advice if excessive ingestion occurs
Firefighting Measures
- Fire Hazards: Non-flammable, but may burn under extreme heat
- Extinguishing Media: Water spray, foam, dry chemical, or CO₂
- Special Precautions: Avoid inhalation of smoke from burning material
- Combustion Products: Carbon oxides and other organic compounds
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