Maninitol BP
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Maninitol BP is a white, crystalline, sugar alcohol derived from mannose, widely used in pharmaceutical, food, and cosmetic industries. It functions as a sweetener, humectant, and excipient. Mannitol BP is non-hygroscopic and has low sweetness compared to sucrose, making it ideal for sugar-free formulations. It is commonly employed in tablet manufacturing as a filler and binder, and in medical settings as an osmotic diuretic to reduce intracranial pressure. The British Pharmacopoeia (BP) grade ensures compliance with pharmacopeial standards for purity and quality.
Categories: Sweeteners, Excipients
Tags: Food additive, Mannitol BP, Pharmaceutical Grade, Sugar alcohol, Sweetener
Description
Table of Contents
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Maninitol BP
Primary Uses
- Pharmaceutical Industry
- Excipient in Tablets and Capsules: Used as a filler, binder, and diluent due to its compressibility and stability.
- Osmotic Diuretic Agent: Administered intravenously to reduce brain edema and treat increased intracranial pressure.
- Carrier for Medicinal Formulations: Employed in powders and sprays for respiratory therapies.
- Food Industry
- Low-Calorie Sweetener: Used in sugar-free and diabetic-friendly food products, including chewing gum, candies, and baked goods.
- Humectant: Retains moisture in food products, extending shelf life and improving texture.
- Cosmetic Industry
- Moisturizer and Humectant: Incorporated in creams, lotions, and personal care products to maintain hydration.
- Texture Enhancer: Improves spreadability and feel of topical formulations.
Secondary Uses
- Medical Diagnostics
- Used in diagnostic solutions and as an additive in intravenous fluids.
- Industrial Applications
- Occasionally used in manufacturing processes requiring non-hygroscopic sugar alcohols.
PRODUCT KEY FEATURES
- Basic Identification Attributes
- Chemical Name (IUPAC): (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol
- Common/Trade Name: Mannitol BP
- CAS Number: 69-65-8
- HS Code: 2905.44.00
- Synonyms: Mannitol; Mannite; D-Mannitol; Sorbitol isomer
- Physical & Chemical Properties
- Physical State: Crystalline powder or granules
- Color & Odor: White; odorless
- Molecular Formula: C₆H₁₄O₆
- Molecular Weight: 182.17 g/mol
- Solubility: Soluble in water (about 22% at 25°C), practically insoluble in ethanol and ether
- Melting Point: 165–170 °C (decomposes)
- Density: ~1.52 g/cm³
- Taste: Mildly sweet
- Safety & Hazard Attributes
- GHS Classification:
- Not classified as hazardous
- Toxicity:
- Non-toxic and generally recognized as safe (GRAS)
- Exposure Limits:
- No occupational exposure limits established
- Storage & Handling Attributes
- Storage Conditions:
- Store in a cool, dry, well-ventilated place away from moisture and direct sunlight
- Container Type:
- Supplied in sealed plastic or paper bags with moisture barriers
- Shelf Life:
- Typically 2–3 years when stored properly
- Handling Precautions:
- Avoid dust generation
- Use standard hygiene practices
- Regulatory & Compliance Attributes
- Complies with British Pharmacopoeia (BP) standards
- Approved for food and pharmaceutical applications globally
- Meets requirements for pharmaceutical excipients and food additives
- Environmental & Health Impact
- Biodegradability: Readily biodegradable
- Ecotoxicity: Low toxicity to aquatic life
- Bioaccumulation: Not expected to bioaccumulate
- Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic
SAFETY HANDLING PRECAUTIONS
- Safety Handling Precautions
- PPE Required:
- Use gloves and dust masks if handling large quantities to avoid inhalation
- Handling Guidelines:
- Handle in well-ventilated areas
- Avoid generating dust
- Storage Measures:
- Keep containers tightly closed and dry
- Store away from incompatible substances such as strong oxidizers
- First Aid Measures
- Inhalation: Move to fresh air if respiratory irritation occurs
- Skin Contact: Wash with soap and water
- Eye Contact: Rinse eyes thoroughly with water; seek medical advice if irritation persists
- Ingestion: Generally safe; excessive intake may cause laxative effects; seek medical advice if adverse symptoms appear
- Firefighting Measures
- Fire Hazards: Non-flammable but may burn under intense heat
- Extinguishing Media: Water spray, foam, dry chemical, or carbon dioxide extinguishers
- Special Precautions: Avoid dust cloud formation which may pose explosion hazard in confined spaces
- Hazardous Combustion Products: Carbon oxides and other toxic fumes
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