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Nicotinamide BP
Nicotinamide BP, also known as niacinamide, is a water-soluble form of vitamin B3 (niacin). It is a vital nutrient involved in numerous cellular processes, including energy metabolism, DNA repair, and antioxidant activity. Widely used in pharmaceutical, cosmetic, and nutritional applications, Nicotinamide supports skin health, improves barrier function, and exhibits anti-inflammatory properties. It is commonly found in dietary supplements, skincare formulations, and medical treatments for various dermatological conditions.
Nicotinamide BP
Primary Uses
- Pharmaceutical Applications
- Used in supplements to prevent and treat niacin deficiency (pellagra).
- Incorporated in treatments for acne, rosacea, and other inflammatory skin disorders.
- Supports nervous system health and energy metabolism.
- Cosmetic Industry
- Added to skincare products for its anti-aging, moisturizing, and skin-brightening effects.
- Helps reduce hyperpigmentation and improves skin elasticity.
- Acts as an anti-inflammatory agent to soothe irritated skin.
- Nutritional Supplements
- Formulated into vitamins and multivitamins to support overall health.
- Enhances cellular metabolism and energy production.
Secondary Uses
- Medical Research
- Investigated for roles in neurodegenerative disease prevention and management.
- Explored for potential benefits in diabetes management and cardiovascular health.
- Food Fortification
- Used to fortify foods and beverages with vitamin B3 to improve nutritional value.
- Animal Nutrition
- Included in animal feed to prevent deficiency and support growth and metabolism.
1. Basic Identification Attributes
- Chemical Name (IUPAC): Pyridine-3-carboxamide
- Common/Trade Name: Nicotinamide, Niacinamide
- CAS Number: 98-92-0
- HS Code: 2934.99.90
- Synonyms: Niacinamide, Vitamin B3 amide
2. Physical & Chemical Properties
- Physical State: White crystalline powder
- Color & Odor: Odorless or faint odor
- Solubility: Soluble in water, alcohol; slightly soluble in ether
- Melting Point: 129–131°C
- Molecular Formula: C₆H₆N₂O
3. Safety & Hazard Attributes
- GHS Classification: Not classified as hazardous under normal use
- Toxicity: Low toxicity; generally recognized as safe (GRAS) for oral consumption
- Exposure Limits: No specific occupational exposure limits
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry, well-ventilated place away from direct sunlight
- Container Type: Sealed plastic or glass containers
- Shelf Life: Typically 2–3 years if stored properly
- Handling Precautions: Avoid dust formation; use protective mask if dusty
5. Regulatory & Compliance Attributes
- Complies with USP, BP, and FCC standards for pharmaceutical and food-grade use
- Approved by regulatory bodies as a vitamin supplement and cosmetic ingredient
- Listed in WHO Essential Medicines list for niacin deficiency treatment
6. Environmental & Health Impact
- Biodegradability: Biodegradable under normal environmental conditions
- Ecotoxicity: Low environmental toxicity
- Bioaccumulation: Not expected to bioaccumulate
- Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic
Safety Handling Precautions
- PPE Required: Gloves and dust mask recommended when handling powders
- Handling Guidelines: Use in well-ventilated areas; avoid inhalation of dust
- Storage Measures: Keep containers tightly closed and away from incompatible substances
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if symptoms persist
- Skin Contact: Wash with soap and water; discontinue use if irritation develops
- Eye Contact: Rinse immediately with plenty of water for 15 minutes; seek medical help if irritation continues
- Ingestion: Generally safe; in case of overdose, seek medical advice
Firefighting Measures
- Fire Hazards: Non-flammable
- Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguisher
- Special Precautions: None specific; standard firefighting procedures apply
- Hazardous Combustion Products: May emit carbon oxides and nitrogen oxides under fire
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