Awaiting product image
Click to enlarge
PVP K 90 USP Amaris Chemicals
PVP K 90 USP
Back to products
Rafoxanide BP Vet Amaris Chemicals
Rafoxanide BP Vet
PHARMACEUTICAL GRADE USP GRADE

Pyrimethamine HCL Micronised

Whatsapp Order

Pyrimethamine HCL Micronised is a finely ground form of pyrimethamine hydrochloride, an antimalarial and antiparasitic drug. The micronised form enhances bioavailability by improving dissolution rate and absorption. It acts by inhibiting dihydrofolate reductase, interfering with folic acid metabolism in protozoa and some bacteria, thus effectively treating malaria and toxoplasmosis. This pharmaceutical-grade compound is used primarily in combination therapies for parasitic infections.

Add to compare
Add to wishlist
Categories: , Tags: , , ,
Description

Primary Uses

Pharmaceutical Industry
Used as an active pharmaceutical ingredient (API) in antimalarial medications, often combined with sulfadoxine (e.g., Fansidar) for treating Plasmodium falciparum malaria.

Employed in the treatment of toxoplasmosis, especially in immunocompromised patients.

Utilized in combination therapy for other parasitic infections sensitive to folate pathway inhibition.

Secondary Uses

Veterinary Medicine
Used in veterinary antiparasitic formulations for protozoal infections in animals.

Research & Development
Utilized in pharmaceutical research for new antimalarial drug development and formulation studies.

Used as a reference standard in analytical and pharmacokinetic studies.

PRODUCT KEY FEATURES

 

Basic Identification Attributes
Chemical Name (IUPAC): 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine hydrochloride

Common/Trade Name: Pyrimethamine HCL Micronised

CAS Number: 145-62-8

HS Code: 2933.99.90

Synonyms: Daraprim (brand name), Pyrimethamine hydrochloride

Physical & Chemical Properties
Physical State: Fine white to off-white powder

Solubility: Slightly soluble in water; soluble in dilute acids

Particle Size: Micronised for enhanced dissolution

Molecular Weight: 248.7 g/mol (free base), hydrochloride salt varies slightly

Odor & Color: Odorless; white powder

 

Safety & Hazard Attributes
GHS Classification: Harmful if swallowed; may cause skin and eye irritation

Toxicity: Moderate toxicity; handle with care to avoid exposure

Exposure Limits: Follow pharmaceutical safety guidelines

Storage & Handling Attributes
Storage Conditions: Store in a tightly closed container in a cool, dry, and well-ventilated area protected from light

Container Type: Sealed plastic or glass containers, foil-lined bags

Shelf Life: Typically 2–3 years if stored properly

Handling Precautions: Use gloves, mask, and eye protection; avoid dust inhalation

 

Regulatory & Compliance Attributes
Complies with USP/NF monograph for pyrimethamine hydrochloride

Manufactured under GMP conditions for pharmaceutical use

 

Environmental & Health Impact
Biodegradability: Not readily biodegradable

Ecotoxicity: Toxic to aquatic organisms at high concentrations

Bioaccumulation: Not significant

SAFETY HANDLING PRECAUTIONS

PPE Required: Gloves, dust mask, goggles recommended

Handling Guidelines: Use in well-ventilated areas; avoid skin and eye contact

Storage Measures: Keep containers tightly closed and stored in a dry, cool environment away from light

 

First Aid Measures
Inhalation: Move to fresh air; seek medical attention if symptoms develop

Skin Contact: Wash with soap and water; seek medical advice if irritation persists

Eye Contact: Rinse with plenty of water for 15 minutes; seek medical attention if irritation continues

Ingestion: Do not induce vomiting; seek immediate medical attention

 

Firefighting Measures
Fire Hazards: Not highly flammable but may decompose on heating releasing toxic fumes

Extinguishing Media: Use water spray, foam, dry chemical, or COâ‚‚

Special Precautions: Wear protective clothing and self-contained breathing apparatus

Hazardous Combustion Products: Carbon oxides, nitrogen oxides, hydrogen chloride

Related products

-25%
Methanol Amaris Chemicals
Add to compare

Methanol

Original price was: $ 2.00.Current price is: $ 1.50.
Methanol, also known as methyl alcohol or wood alcohol, is a clear, colorless, volatile, and flammable liquid with a distinct alcoholic odor. It is the simplest alcohol and is widely used as an industrial solvent, antifreeze, fuel, and chemical feedstock. Methanol is highly miscible with water and many organic solvents and serves as a precursor to numerous chemicals including formaldehyde, acetic acid, and various plastic
Add to wishlist
Add to cart
Quick view
Placeholder
Add to compare

Methyl Cellulose 400mpc

Methyl Cellulose 400 MPC is a chemically modified cellulose derivative in powder form. It is a non-ionic, water-soluble polymer widely used as a thickener, binder, emulsifier, and film former. It exhibits excellent water retention, viscosity control, and thermal gelation properties, making it ideal for applications in construction, pharmaceuticals, food, and cosmetics.
Add to wishlist
Read more
Quick view
Placeholder
Add to compare

Methyl Paraben

Methyl Paraben is a white to off-white crystalline powder widely used as an antimicrobial preservative in cosmetics, pharmaceuticals, and food products. It is a member of the paraben family of preservatives known for their effectiveness against a broad spectrum of bacteria and fungi. Methyl Paraben helps extend the shelf life of products by preventing microbial growth without affecting the product's texture or color.
Add to wishlist
Read more
Quick view
Michelia Flower oil Amaris Chemicals
Add to compare

Michelia Flower Oil

Michelia Flower Oil is an essential oil extracted through steam distillation or solvent extraction from the flowers of Michelia species (e.g., Michelia champaca, Michelia alba). Known for its rich, floral, and slightly fruity aroma, it is widely used in perfumery, aromatherapy, and traditional medicine. The oil is prized for its therapeutic properties and as a natural fragrance ingredient.
Add to wishlist
Read more
Quick view
Micro crystalline Wax Amaris Chemicals
Add to compare

Micro crystalline Wax

Micro crystalline Wax is a refined petroleum-derived wax with fine crystalline structure, used across multiple industries for its binding, coating and waterproofing properties. It is characterized by its low melting point (typically 60-85°C) and excellent plasticity.
Add to wishlist
Read more
Quick view
Placeholder
Add to compare

Pineapple Enzyme Powder

Pineapple Enzyme Powder is a fine, light-colored powder derived from the fruit and stem of the pineapple (Ananas comosus), containing the proteolytic enzyme bromelain. It is produced via extraction and subsequent drying (usually spray or freeze-drying) to preserve enzymatic activity. Known for its protein-digesting, anti-inflammatory, and exfoliating properties, this enzyme is widely used across food, nutraceutical, cosmetic, and pharmaceutical industries.
Add to wishlist
Read more
Quick view
Placeholder
Add to compare

Potassium Citrate

Potassium Citrate is a potassium salt of citric acid, appearing as a white, crystalline, water-soluble powder. It is widely used in food, pharmaceutical, agricultural, and industrial applications due to its buffering, alkalizing, and sequestrant properties. Potassium Citrate helps regulate acidity and provides potassium ions critical for various biochemical and physiological functions.
Add to wishlist
Read more
Quick view
Placeholder
Add to compare

Potassium Lactate

Potassium Lactate is the potassium salt of lactic acid, typically available as a clear, colorless to pale yellow liquid or solid powder. It functions primarily as a food additive, humectant, and preservative with antimicrobial properties. Widely used in the food industry, it also finds applications in pharmaceuticals, cosmetics, and industrial processes. Potassium Lactate helps improve moisture retention, extend shelf life, and enhance safety by inhibiting microbial growth.
Add to wishlist
Read more
Quick view