Preservatives(food)
Flavor Enhancers
Acidulants
Sweeteners
Antioxidants
Colorants(food)
Nutraceutical Ingredients (food)
Nutrient Supplements
Emulsifiers
Collectors
Dust Suppressants
Explosives and Blasting Agents
Flocculants and Coagulants
Frothers
Leaching Agents
pH Modifiers
Precious Metal Extraction Agents
Antioxidants(plastic)
Colorants (Pigments, Dyes)
Fillers and Reinforcements
Flame Retardants
Monomers
Plasticizers
Polymerization Initiators
Stabilizers (UV, Heat)
Antifoaming Agents
Chelating Agents
Coagulants and Flocculants
Corrosion Inhibitors
Disinfectants and Biocides
Oxidizing Agents
pH Adjusters
Scale Inhibitors( water)
Antioxidants(cosmetic)
Emollients
Fragrances and Essential Oils
Humectants
Preservatives
Surfactants(cosmetic)
Thickeners
UV Filters
Fertilizers
Soil Conditioners
Plant Growth Regulators
Animal Feed Additives
Biostimulants
Pesticides (Herbicides, Insecticides, Fungicides)
Active Pharmaceutical Ingredients (APIs)
Excipients
Solvents(pharmaceutical)
Antibiotics
Antiseptics and Disinfectants
Vaccine Adjuvants
Nutraceutical Ingredients (pharmaceutical)
Analgesics & Antipyretics
Analytical Reagents
Solvents(lab)
Chromatography Chemicals
Spectroscopy Reagents
microbiology-and-cell-culture-reagents
Molecular Biology Reagents
Biochemical Reagents
Inorganic and Organic Standards
Laboratory Safety Chemicals
Specialty Laboratory Chemicals(Special Laboratory Equipment)
Demulsifiers
Hydraulic Fracturing Fluids
Scale Inhibitors(oil)
Surfactants(oil)
Drilling Fluids
Dyes and Pigments
Bleaching Agents
Softening Agents
Finishing Agents
Antistatic Agents
Admixtures
Waterproofing Agents
Sealants and Adhesives
Curing Compounds
Concrete Repair Chemicals
Anti-Corrosion Coatings
Surfactants(cleaning)
Builders
Enzymes
Solvents (Cleaning)
Fragrances
Electronic Chemicals
Catalysts
Lubricants
Photographic Chemicals
Refrigerants
Automotive chemicals
Pyrotechnic Chemicals
Biodegradable Surfactants
Bio-based Solvents
Renewable Polymers
Carbon Capture Chemicals
Wastewater Treatment Chemicals
Pigments
Solvents(paint)
Specialty Coatings
Binders/Resins
Additives
Driers
Anti-Corrosion Agents
Functional Coatings
Application-Specific Coatings
Fresh Herbs
Ground Spices
Whole Spices
Spice Blends
Dried Herbs
Leavening Agents
Dough Conditioners
Flour Treatments
Fat Replacers
Decoratives
Preservatives(baking)
Plasticizers & Softeners
Reinforcing Agents
Adhesion Promoters
Vulcanizing Agents
Antidegradants
Blowing Agents
Fillers & Extenders
Accelerators & Retarders
Pyrimethamine HCL Micronised
Whatsapp Order
Pyrimethamine HCL Micronised is a finely ground form of pyrimethamine hydrochloride, an antimalarial and antiparasitic drug. The micronised form enhances bioavailability by improving dissolution rate and absorption. It acts by inhibiting dihydrofolate reductase, interfering with folic acid metabolism in protozoa and some bacteria, thus effectively treating malaria and toxoplasmosis. This pharmaceutical-grade compound is used primarily in combination therapies for parasitic infections.
Description
Pyrimethamine HCL Micronised
Primary Uses
- Pharmaceutical Industry
- Used as an active pharmaceutical ingredient (API) in antimalarial medications, often combined with sulfadoxine (e.g., Fansidar) for treating Plasmodium falciparum malaria.
- Employed in the treatment of toxoplasmosis, especially in immunocompromised patients.
- Utilized in combination therapy for other parasitic infections sensitive to folate pathway inhibition.
Secondary Uses
- Veterinary Medicine
- Used in veterinary antiparasitic formulations for protozoal infections in animals.
- Research & Development
- Utilized in pharmaceutical research for new antimalarial drug development and formulation studies.
- Used as a reference standard in analytical and pharmacokinetic studies.
KEY PRODUCT FEATURES
1. Basic Identification Attributes
- Chemical Name (IUPAC): 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine hydrochloride
- Common/Trade Name: Pyrimethamine HCL Micronised
- CAS Number: 145-62-8
- HS Code: 2933.99.90
- Synonyms: Daraprim (brand name), Pyrimethamine hydrochloride
2. Physical & Chemical Properties
- Physical State: Fine white to off-white powder
- Solubility: Slightly soluble in water; soluble in dilute acids
- Particle Size: Micronised for enhanced dissolution
- Molecular Weight: 248.7 g/mol (free base), hydrochloride salt varies slightly
- Odor & Color: Odorless; white powder
3. Safety & Hazard Attributes
- GHS Classification: Harmful if swallowed; may cause skin and eye irritation
- Toxicity: Moderate toxicity; handle with care to avoid exposure
- Exposure Limits: Follow pharmaceutical safety guidelines
4. Storage & Handling Attributes
- Storage Conditions: Store in a tightly closed container in a cool, dry, and well-ventilated area protected from light
- Container Type: Sealed plastic or glass containers, foil-lined bags
- Shelf Life: Typically 2–3 years if stored properly
- Handling Precautions: Use gloves, mask, and eye protection; avoid dust inhalation
5. Regulatory & Compliance Attributes
- Complies with USP/NF monograph for pyrimethamine hydrochloride
- Manufactured under GMP conditions for pharmaceutical use
6. Environmental & Health Impact
- Biodegradability: Not readily biodegradable
- Ecotoxicity: Toxic to aquatic organisms at high concentrations
- Bioaccumulation: Not significant
SAFETY HANDLING PRECAUTIONS
Safety Handling Precautions
- PPE Required: Gloves, dust mask, goggles recommended
- Handling Guidelines: Use in well-ventilated areas; avoid skin and eye contact
- Storage Measures: Keep containers tightly closed and stored in a dry, cool environment away from light
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if symptoms develop
- Skin Contact: Wash with soap and water; seek medical advice if irritation persists
- Eye Contact: Rinse with plenty of water for 15 minutes; seek medical attention if irritation continues
- Ingestion: Do not induce vomiting; seek immediate medical attention
Firefighting Measures
- Fire Hazards: Not highly flammable but may decompose on heating releasing toxic fumes
- Extinguishing Media: Use water spray, foam, dry chemical, or CO₂
- Special Precautions: Wear protective clothing and self-contained breathing apparatus
- Hazardous Combustion Products: Carbon oxides, nitrogen oxides, hydrogen chloride
Related products
Carbocisteine AJI 92
Carbocisteine AJI 92 is a high-purity pharmaceutical-grade amino acid derivative, chemically known as S-carboxymethyl-L-cysteine. It is a white to off-white crystalline powder with a slightly sulfurous odor and is freely soluble in water. Carbocisteine functions primarily as a mucolytic agent—reducing the viscosity of mucus and promoting expectoration in respiratory tract infections. The "AJI 92" specification refers to its compliance with the purity standards established by Ajinomoto's amino acid quality benchmarks, ensuring it meets stringent pharmaceutical-grade quality control for active pharmaceutical ingredients (APIs). It is widely used in oral syrups, tablets, and granules in both human and veterinary medicine.
Cetirizine Dihydrochloride
Cetirizine Dihydrochloride is a second-generation antihistamine widely used to relieve allergy symptoms such as hay fever, urticaria (hives), and other allergic conditions. It is the dihydrochloride salt form of cetirizine, presenting as a white to off-white crystalline powder that is odorless or nearly odorless and slightly bitter in taste. Cetirizine Dihydrochloride acts as a selective antagonist of peripheral H1 histamine receptors, preventing the effects of histamine and thereby reducing allergic symptoms without causing significant sedation. It is a commonly prescribed active pharmaceutical ingredient (API) in oral tablets, syrups, and capsules.
Diloxanide Furoate
Diloxanide Furoate is an orally administered antiprotozoal agent used primarily for the treatment of amoebiasis. It is a furan-based derivative that acts as a luminal amoebicide, effectively targeting Entamoeba histolytica cysts and trophozoites within the intestinal lumen. This compound is well-regarded for its efficacy in eradicating asymptomatic cyst carriers and as a follow-up treatment after systemic amoebicidal therapy. Diloxanide Furoate has good oral bioavailability and a favorable safety profile.
Enrofloxacin Hydrochloride
Enrofloxacin Hydrochloride is a broad-spectrum fluoroquinolone antibiotic used primarily in veterinary medicine. It is the hydrochloride salt of enrofloxacin, offering enhanced solubility and bioavailability. Enrofloxacin inhibits bacterial DNA gyrase and topoisomerase IV, disrupting DNA replication in Gram-negative and Gram-positive organisms as well as some Mycoplasma species. It is available as a white to off-white crystalline powder, used in injectable, oral, and topical formulations designed for livestock, companion animals, and aquatic species.
Gentamycin Sulphate
Gentamycin Sulphate is an aminoglycoside antibiotic derived from Micromonospora purpurea and Micromonospora griseorubida. It appears as a white or off-white crystalline powder, highly soluble in water, with a characteristic aminoglycoside odor. Gentamycin Sulphate is widely used in human and veterinary medicine for its broad-spectrum bactericidal activity against aerobic Gram-negative and some Gram-positive bacteria. It works by inhibiting bacterial protein synthesis through binding to the 30S ribosomal subunit, leading to bacterial cell death. Due to its effectiveness against severe infections and multi-drug resistant strains, it is an essential antibiotic in clinical settings.
Guaiphenesin BP
Guaiphenesin BP is a white crystalline powder or granules with a faint characteristic odor, classified as an expectorant used primarily in pharmaceutical formulations to relieve chest congestion. It works by loosening and thinning mucus in the airways, making it easier to cough up and clear from the respiratory tract. It is widely utilized in cough syrups, tablets, and cold remedies. Recognized for its mucolytic and muscle-relaxant properties, Guaiphenesin is included in both prescription and over-the-counter medications worldwide.
Hydrocortisone Base BP 93 Micro
Hydrocortisone Base BP 93 Micro is a highly purified, micronized form of hydrocortisone base compliant with British Pharmacopoeia (BP) standards. It is a white to off-white fine powder designed for enhanced solubility and bioavailability in pharmaceutical formulations. As a corticosteroid hormone analog, it exhibits potent anti-inflammatory, immunosuppressive, and anti-allergic activities. The micronized particle size (~93 microns) facilitates improved dispersion in topical, injectable, and oral dosage forms.
Lidocaine HCL BP
Lidocaine HCL BP is a white crystalline powder or granules that are highly soluble in water. It is a local anesthetic and antiarrhythmic agent widely used in medical and dental fields. Lidocaine HCL BP acts by blocking nerve signal transmission, providing rapid and effective numbing of targeted areas. It conforms to British Pharmacopoeia (BP) standards, ensuring pharmaceutical-grade purity and consistency. It is commonly formulated into injections, topical gels, creams, and patches for pain relief and arrhythmia treatment.
