Sodium Starch Glycolate Amaris Chemicals

Sodium Starch Glycolate

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Sodium Starch Glycolate (SSG) is a white to off-white, odorless, tasteless powder derived from potato or maize starch and chemically modified with carboxymethylation and cross-linking. It has the chemical formula (C₆H₁₀O₅)nNa and is widely used in solid dosage pharmaceutical formulations as a superdisintegrant. This 25kg grade is supplied in high-purity pharmaceutical and food-grade quality, offering excellent swelling capacity and rapid disintegration properties even at low concentrations.

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Category: Excipients Tags: Crosslinked Sodium Carboxymethyl Starch, Food & Beverage Industry, Nutraceuticals, Pharmaceutical excipient, Sodium Starch Glycolate, Superdisintegrant, White powder

Description

Table of Contents

Sodium Starch Glycolate

Primary Uses

Pharmaceutical Industry

Tablet Disintegrant: Promotes rapid breakup of tablets in the gastrointestinal tract for improved bioavailability.
Capsule Disintegrant: Enhances dissolution of active ingredients in hard and soft gelatin capsules.
Granule Disintegrant: Used in multi-particulate systems such as sachets or sprinkle formulations.
Direct Compression Formulations: Enhances flowability and compressibility of powder blends.
Modified Release Formulations: Used in fast-dissolving or orally disintegrating tablets (ODTs).
Effervescent Tablets: Facilitates rapid dissolution along with effervescence.
Nutraceutical Tablets: Widely used in dietary supplements, vitamins, and herbal tablets.

Food Industry

Food Additive: Used as a processing aid or disintegrant in chewable dietary supplements.
Carrier for Flavors or Nutrients: Occasionally employed to aid dispersion of encapsulated flavors.
Starch Replacement: In limited food-grade applications for specialty powder formulations.

Cosmetic & Personal Care

Powdered Cosmetic Products: Improves texture, spreadability, and moisture absorption in talc substitutes or facial powders.
Topical Tablets or Patches: Disintegrates rapidly when exposed to moisture, aiding in rapid release of actives.

Veterinary Medicine

Animal Tablets and Boluses: Used in pet or livestock tablets to enhance disintegration in digestive tract.
Nutritional Supplements for Animals: Aids in dispersion of vitamins and minerals.

Secondary Uses

Industrial Applications

Binder/Disintegrant in Specialty Chemicals: Occasionally used in powder-pressed catalysts or enzymatic tablets.
Biodegradable Plastics Additive: Explored in biopolymer formulations for improving disintegration profile.

Agricultural Products

Seed Coatings (Experimental): Enhances moisture activation in germination-accelerating coatings.
Pesticide Tablet Formulations: Used as a disintegrant in slow-release pesticide tablets.

Research & Laboratory

Drug Formulation Testing: Common excipient in pharmaceutical formulation development.
In-vitro Dissolution Studies: Utilized in the design of model tablets for research applications.

KEY PRODUCT FEATURES

1. Basic Identification Attributes

Chemical Name (IUPAC): Sodium salt of a carboxymethyl ether of starch
Common/Trade Name: Sodium Starch Glycolate (SSG)
CAS Number: 9005-25-8 (starch base), 9063-38-1 (SSG)
HS Code: 3505.10.00
Synonyms: Carboxymethyl starch sodium salt, Cross-linked carboxymethyl starch sodium

2. Physical & Chemical Properties

Physical State: Free-flowing hygroscopic powder
Color & Odor: White to off-white; odorless
Solubility: Practically insoluble in water; swells extensively
Moisture Content: ≤10%
Particle Size: 90% < 100 µm (typical)
pH (1% dispersion): 5.5–7.5
Swelling Capacity: Can swell 20–30 times its weight in water

3. Safety & Hazard Attributes

GHS Classification: Not classified as hazardous
Toxicity: LD₅₀ (oral, rat) > 5000 mg/kg
Exposure Limits: Not established; general dust exposure limits apply
Allergen Status: Derived from non-gluten sources (e.g., potato or maize)

4. Storage & Handling Attributes

Storage Conditions: Store in cool, dry, well-ventilated area; protect from moisture
Container Type: 25kg fiber drums or multi-wall paper bags with polyethylene liner
Shelf Life: 24–36 months in original sealed packaging
Handling Precautions: Avoid dust generation; use in controlled environments

5. Regulatory & Compliance Attributes

Pharmacopoeia Compliance:
- USP/NF, Ph.Eur, JP, IP compliant grades available
Food Additive Status: Approved for food supplement use in several jurisdictions
REACH Exempt (natural polymer)
GRAS Status: Generally Recognized as Safe for intended uses
Halal, Kosher, and Non-GMO Grades: Available from specific suppliers

6. Environmental & Health Impact

Biodegradability: Fully biodegradable
Ecotoxicity: Not harmful to aquatic or terrestrial life
Bioaccumulation: Not expected
Aquatic Impact: Negligible at typical use concentrations

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE Required: Dust mask, gloves, safety goggles in bulk handling
Handling Guidelines: Use dust control systems; avoid inhalation
Storage Measures: Store in sealed packaging; avoid exposure to humidity

First Aid Measures

Inhalation: Move to fresh air; seek medical help if symptoms persist
Skin Contact: Wash with water; no known irritation
Eye Contact: Rinse thoroughly with water; seek help if irritation occurs
Ingestion: Non-toxic; rinse mouth and drink water if large amount is ingested