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Sulphadoxine
Sulphadoxine BP is a long-acting synthetic sulfonamide antibiotic used primarily in combination therapies for treating malaria and certain bacterial infections. Its prolonged half-life makes it suitable for single-dose treatments and prophylaxis. The British Pharmacopoeia (BP) 98% grade ensures pharmaceutical-grade purity, making it suitable for incorporation into human and veterinary medicinal formulations.
Sulphadoxine
Primary Uses
- Human Medicine
- Antimalarial Agent: Primarily used in combination with pyrimethamine (as Fansidar) for treatment and prophylaxis of malaria, especially Plasmodium falciparum infections.
- Antibacterial Agent: Occasionally used to treat bacterial infections susceptible to sulfonamides, particularly in tropical regions.
- Veterinary Medicine
- Antimicrobial Agent: Used in combination therapies for prevention and treatment of protozoal and bacterial infections in livestock.
Secondary Uses
- Research & Development
- Pharmaceutical Studies: Used in pharmacokinetic and formulation research for antimalarial and sulfonamide drugs.
- Drug Resistance Monitoring: Utilized in studies monitoring drug resistance patterns in malaria parasites.
- Public Health Programs
- Mass Drug Administration: Employed in malaria-endemic regions as part of public health interventions.
1. Basic Identification Attributes
- Chemical Name (IUPAC): 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
- Common/Trade Name: Sulphadoxine BP 98
- CAS Number: 2447-57-6
- HS Code: 2941.20.00
- Synonyms: Sulfadoxine, Sulphadoxine
2. Physical & Chemical Properties
- Physical State: White crystalline powder
- Color & Odor: White; odorless to faint sulfur-like odor
- Melting Point: 190–194 °C
- Solubility: Slightly soluble in water; soluble in alkaline solutions and organic solvents
- Density: Approx. 1.5 g/cm³
3. Safety & Hazard Attributes
- GHS Classification: May cause allergic skin reactions and serious hypersensitivity reactions
- Toxicity: Moderate toxicity; risk of severe adverse reactions like Stevens-Johnson syndrome
- Exposure Limits: No specific occupational limits; handle with care
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry, well-ventilated area, away from light and moisture
- Container Type: Sealed HDPE or glass containers
- Shelf Life: 24 months under recommended storage conditions
- Handling Precautions: Avoid dust generation; use PPE such as gloves and masks
5. Regulatory & Compliance Attributes
- Complies with British Pharmacopoeia (BP) standards
- Manufactured under Good Manufacturing Practices (GMP)
- Approved for use in antimalarial combination therapies by relevant regulatory authorities
6. Environmental & Health Impact
- Biodegradability: Limited biodegradability under aerobic conditions
- Ecotoxicity: Potentially toxic to aquatic organisms; avoid environmental release
- Bioaccumulation: Not significant
Safety Handling Precautions
- PPE Required: Gloves, protective clothing, and dust masks recommended
- Handling Guidelines: Use in well-ventilated areas; avoid inhalation and skin contact
- Storage Measures: Keep containers tightly closed and dry
First Aid Measures
- Inhalation: Remove to fresh air; seek medical attention if respiratory symptoms develop
- Skin Contact: Wash thoroughly with soap and water; discontinue use if irritation occurs
- Eye Contact: Rinse eyes with water for at least 15 minutes; seek medical help if irritation persists
- Ingestion: Rinse mouth and seek medical advice promptly
Firefighting Measures
- Fire Hazards: Combustible solid
- Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguishers
- Hazardous Combustion Products: Carbon oxides, nitrogen oxides, sulfur oxides
Related products
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Cetirizine Dihydrochloride
Cetirizine Dihydrochloride is a second-generation antihistamine widely used to relieve allergy symptoms such as hay fever, urticaria (hives), and other allergic conditions. It is the dihydrochloride salt form of cetirizine, presenting as a white to off-white crystalline powder that is odorless or nearly odorless and slightly bitter in taste. Cetirizine Dihydrochloride acts as a selective antagonist of peripheral H1 histamine receptors, preventing the effects of histamine and thereby reducing allergic symptoms without causing significant sedation. It is a commonly prescribed active pharmaceutical ingredient (API) in oral tablets, syrups, and capsules.
Diloxanide Furoate
Diloxanide Furoate is an orally administered antiprotozoal agent used primarily for the treatment of amoebiasis. It is a furan-based derivative that acts as a luminal amoebicide, effectively targeting Entamoeba histolytica cysts and trophozoites within the intestinal lumen. This compound is well-regarded for its efficacy in eradicating asymptomatic cyst carriers and as a follow-up treatment after systemic amoebicidal therapy. Diloxanide Furoate has good oral bioavailability and a favorable safety profile.
Ivermectin BP Vet
Ivermectin BP Vet is a potent, broad-spectrum antiparasitic agent widely used in veterinary medicine. It belongs to the avermectin family and works by disrupting nerve and muscle function in parasites, leading to paralysis and death. Ivermectin is highly effective against a range of internal and external parasites, including gastrointestinal worms, lungworms, mites, lice, and certain ticks. Available in oral, injectable, and topical forms, it is trusted for use in livestock, poultry, and companion animals. Its reliable efficacy, wide safety margin, and ease of administration make it an essential treatment in animal health and parasite control programs.
Lidocaine HCL BP
Lidocaine HCL BP is a white crystalline powder or granules that are highly soluble in water. It is a local anesthetic and antiarrhythmic agent widely used in medical and dental fields. Lidocaine HCL BP acts by blocking nerve signal transmission, providing rapid and effective numbing of targeted areas. It conforms to British Pharmacopoeia (BP) standards, ensuring pharmaceutical-grade purity and consistency. It is commonly formulated into injections, topical gels, creams, and patches for pain relief and arrhythmia treatment.
Mepyramine Maleate BP
Mepyramine Maleate BP is an antihistamine drug commonly used to relieve allergic symptoms such as hay fever, urticaria, and other allergic reactions. It works by blocking histamine H1 receptors, reducing allergic responses like itching, swelling, and redness. This compound is a white or off-white crystalline powder, soluble in water and alcohol, widely used in pharmaceutical formulations including tablets, creams, and injectables.
Metronidazole Benzoate BP
Metronidazole Benzoate BP is a benzoate ester derivative of metronidazole, used primarily as an antiprotozoal and antibacterial agent. It is a prodrug that hydrolyzes in the body to release metronidazole, making it more palatable for pediatric and geriatric oral suspensions. It complies with the British Pharmacopoeia (BP) standards for purity and efficacy.
Norfloxacin
Norfloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic used primarily to treat bacterial infections. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, repair, and recombination, leading to bacterial cell death. Norfloxacin is effective against various Gram-negative and some Gram-positive bacteria and is commonly used in urinary tract infections, prostatitis, and gastroenteritis.
