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Sulphadoxine
Sulphadoxine BP is a long-acting synthetic sulfonamide antibiotic used primarily in combination therapies for treating malaria and certain bacterial infections. Its prolonged half-life makes it suitable for single-dose treatments and prophylaxis. The British Pharmacopoeia (BP) 98% grade ensures pharmaceutical-grade purity, making it suitable for incorporation into human and veterinary medicinal formulations.
Sulphadoxine
Primary Uses
- Human Medicine
- Antimalarial Agent: Primarily used in combination with pyrimethamine (as Fansidar) for treatment and prophylaxis of malaria, especially Plasmodium falciparum infections.
- Antibacterial Agent: Occasionally used to treat bacterial infections susceptible to sulfonamides, particularly in tropical regions.
- Veterinary Medicine
- Antimicrobial Agent: Used in combination therapies for prevention and treatment of protozoal and bacterial infections in livestock.
Secondary Uses
- Research & Development
- Pharmaceutical Studies: Used in pharmacokinetic and formulation research for antimalarial and sulfonamide drugs.
- Drug Resistance Monitoring: Utilized in studies monitoring drug resistance patterns in malaria parasites.
- Public Health Programs
- Mass Drug Administration: Employed in malaria-endemic regions as part of public health interventions.
1. Basic Identification Attributes
- Chemical Name (IUPAC): 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
- Common/Trade Name: Sulphadoxine BP 98
- CAS Number: 2447-57-6
- HS Code: 2941.20.00
- Synonyms: Sulfadoxine, Sulphadoxine
2. Physical & Chemical Properties
- Physical State: White crystalline powder
- Color & Odor: White; odorless to faint sulfur-like odor
- Melting Point: 190–194 °C
- Solubility: Slightly soluble in water; soluble in alkaline solutions and organic solvents
- Density: Approx. 1.5 g/cm³
3. Safety & Hazard Attributes
- GHS Classification: May cause allergic skin reactions and serious hypersensitivity reactions
- Toxicity: Moderate toxicity; risk of severe adverse reactions like Stevens-Johnson syndrome
- Exposure Limits: No specific occupational limits; handle with care
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry, well-ventilated area, away from light and moisture
- Container Type: Sealed HDPE or glass containers
- Shelf Life: 24 months under recommended storage conditions
- Handling Precautions: Avoid dust generation; use PPE such as gloves and masks
5. Regulatory & Compliance Attributes
- Complies with British Pharmacopoeia (BP) standards
- Manufactured under Good Manufacturing Practices (GMP)
- Approved for use in antimalarial combination therapies by relevant regulatory authorities
6. Environmental & Health Impact
- Biodegradability: Limited biodegradability under aerobic conditions
- Ecotoxicity: Potentially toxic to aquatic organisms; avoid environmental release
- Bioaccumulation: Not significant
Safety Handling Precautions
- PPE Required: Gloves, protective clothing, and dust masks recommended
- Handling Guidelines: Use in well-ventilated areas; avoid inhalation and skin contact
- Storage Measures: Keep containers tightly closed and dry
First Aid Measures
- Inhalation: Remove to fresh air; seek medical attention if respiratory symptoms develop
- Skin Contact: Wash thoroughly with soap and water; discontinue use if irritation occurs
- Eye Contact: Rinse eyes with water for at least 15 minutes; seek medical help if irritation persists
- Ingestion: Rinse mouth and seek medical advice promptly
Firefighting Measures
- Fire Hazards: Combustible solid
- Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguishers
- Hazardous Combustion Products: Carbon oxides, nitrogen oxides, sulfur oxides
Related products
Diclofenac Sodium BP
Diclofenac Sodium is a nonsteroidal anti-inflammatory drug (NSAID) widely used for its potent analgesic, anti-inflammatory, and antipyretic properties. It is the sodium salt form of diclofenac, providing enhanced solubility and rapid absorption. Diclofenac Sodium BP (British Pharmacopoeia standard) ensures pharmaceutical-grade purity and compliance with stringent quality standards. It is commonly formulated in oral tablets, topical gels, injections, and ophthalmic preparations.
Diphenhydramine HCL BP
Diphenhydramine HCL BP is a first-generation antihistamine with potent anticholinergic, sedative, and antiemetic properties. It is commonly used to relieve symptoms associated with allergies, hay fever, the common cold, and motion sickness. Diphenhydramine HCL is a white crystalline powder, highly soluble in water, making it suitable for oral, topical, and injectable pharmaceutical formulations. Due to its ability to cross the blood-brain barrier, it causes sedation and is often used as a sleep aid and for managing Parkinson’s disease symptoms.
Doxycycline Hyclate BP
Doxycycline Hyclate BP is a broad-spectrum, semisynthetic tetracycline-class antibiotic available as the hemihydrate salt form of doxycycline. It is widely used in pharmaceutical formulations due to its high bioavailability, broad antibacterial activity, and favorable pharmacokinetic profile. The compound exhibits bacteriostatic action by inhibiting protein synthesis in susceptible bacteria, making it effective against a wide range of Gram-positive and Gram-negative organisms as well as atypical pathogens. It is typically supplied as a fine, white to off-white crystalline powder soluble in water and suitable for oral and parenteral dosage forms.
Hydrocortisone Acetate
Hydrocortisone Acetate is a synthetic corticosteroid ester derived from hydrocortisone (cortisol). It is a white to off-white crystalline powder, practically insoluble in water but soluble in alcohol and acetone. This compound exhibits potent anti-inflammatory, immunosuppressive, and anti-allergic properties, making it widely used in pharmaceutical and dermatological formulations. Hydrocortisone Acetate acts by modulating gene expression to reduce the production of inflammatory mediators, thereby alleviating symptoms in various inflammatory and autoimmune conditions.
Ivermectin BP Vet
Ivermectin BP Vet is a potent, broad-spectrum antiparasitic agent widely used in veterinary medicine. It belongs to the avermectin family and works by disrupting nerve and muscle function in parasites, leading to paralysis and death. Ivermectin is highly effective against a range of internal and external parasites, including gastrointestinal worms, lungworms, mites, lice, and certain ticks. Available in oral, injectable, and topical forms, it is trusted for use in livestock, poultry, and companion animals. Its reliable efficacy, wide safety margin, and ease of administration make it an essential treatment in animal health and parasite control programs.
Metronidazole Benzoate BP
Metronidazole Benzoate BP is a benzoate ester derivative of metronidazole, used primarily as an antiprotozoal and antibacterial agent. It is a prodrug that hydrolyzes in the body to release metronidazole, making it more palatable for pediatric and geriatric oral suspensions. It complies with the British Pharmacopoeia (BP) standards for purity and efficacy.
Metronidazole BP
Metronidazole BP is a benzoate ester derivative of metronidazole, used primarily as an antiprotozoal and antibacterial agent. It is a prodrug that hydrolyzes in the body to release metronidazole, making it more palatable for pediatric and geriatric oral suspensions. It complies with the British Pharmacopoeia (BP) standards for purity and efficacy.
Neomycin Sulphate BP Oral
Neomycin Sulphate BP Oral is an aminoglycoside antibiotic derived from Streptomyces fradiae. It is used primarily for treating infections caused by susceptible aerobic gram-negative and some gram-positive bacteria. The oral form is especially utilized for intestinal antisepsis, to reduce bacterial flora before gastrointestinal surgery, or to treat hepatic encephalopathy by decreasing ammonia-producing bacteria in the gut. It is available in powder or tablet form conforming to British Pharmacopoeia (BP) standards, ensuring high purity and efficacy.
