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Sulphadoxine
Sulphadoxine BP is a long-acting synthetic sulfonamide antibiotic used primarily in combination therapies for treating malaria and certain bacterial infections. Its prolonged half-life makes it suitable for single-dose treatments and prophylaxis. The British Pharmacopoeia (BP) 98% grade ensures pharmaceutical-grade purity, making it suitable for incorporation into human and veterinary medicinal formulations.
Sulphadoxine
Primary Uses
- Human Medicine
- Antimalarial Agent: Primarily used in combination with pyrimethamine (as Fansidar) for treatment and prophylaxis of malaria, especially Plasmodium falciparum infections.
- Antibacterial Agent: Occasionally used to treat bacterial infections susceptible to sulfonamides, particularly in tropical regions.
- Veterinary Medicine
- Antimicrobial Agent: Used in combination therapies for prevention and treatment of protozoal and bacterial infections in livestock.
Secondary Uses
- Research & Development
- Pharmaceutical Studies: Used in pharmacokinetic and formulation research for antimalarial and sulfonamide drugs.
- Drug Resistance Monitoring: Utilized in studies monitoring drug resistance patterns in malaria parasites.
- Public Health Programs
- Mass Drug Administration: Employed in malaria-endemic regions as part of public health interventions.
1. Basic Identification Attributes
- Chemical Name (IUPAC): 4-Amino-N-(5,6-dimethoxy-4-pyrimidinyl)benzenesulfonamide
- Common/Trade Name: Sulphadoxine BP 98
- CAS Number: 2447-57-6
- HS Code: 2941.20.00
- Synonyms: Sulfadoxine, Sulphadoxine
2. Physical & Chemical Properties
- Physical State: White crystalline powder
- Color & Odor: White; odorless to faint sulfur-like odor
- Melting Point: 190–194 °C
- Solubility: Slightly soluble in water; soluble in alkaline solutions and organic solvents
- Density: Approx. 1.5 g/cm³
3. Safety & Hazard Attributes
- GHS Classification: May cause allergic skin reactions and serious hypersensitivity reactions
- Toxicity: Moderate toxicity; risk of severe adverse reactions like Stevens-Johnson syndrome
- Exposure Limits: No specific occupational limits; handle with care
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry, well-ventilated area, away from light and moisture
- Container Type: Sealed HDPE or glass containers
- Shelf Life: 24 months under recommended storage conditions
- Handling Precautions: Avoid dust generation; use PPE such as gloves and masks
5. Regulatory & Compliance Attributes
- Complies with British Pharmacopoeia (BP) standards
- Manufactured under Good Manufacturing Practices (GMP)
- Approved for use in antimalarial combination therapies by relevant regulatory authorities
6. Environmental & Health Impact
- Biodegradability: Limited biodegradability under aerobic conditions
- Ecotoxicity: Potentially toxic to aquatic organisms; avoid environmental release
- Bioaccumulation: Not significant
Safety Handling Precautions
- PPE Required: Gloves, protective clothing, and dust masks recommended
- Handling Guidelines: Use in well-ventilated areas; avoid inhalation and skin contact
- Storage Measures: Keep containers tightly closed and dry
First Aid Measures
- Inhalation: Remove to fresh air; seek medical attention if respiratory symptoms develop
- Skin Contact: Wash thoroughly with soap and water; discontinue use if irritation occurs
- Eye Contact: Rinse eyes with water for at least 15 minutes; seek medical help if irritation persists
- Ingestion: Rinse mouth and seek medical advice promptly
Firefighting Measures
- Fire Hazards: Combustible solid
- Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguishers
- Hazardous Combustion Products: Carbon oxides, nitrogen oxides, sulfur oxides
Related products
Carbocisteine AJI 92
Carbocisteine AJI 92 is a high-purity pharmaceutical-grade amino acid derivative, chemically known as S-carboxymethyl-L-cysteine. It is a white to off-white crystalline powder with a slightly sulfurous odor and is freely soluble in water. Carbocisteine functions primarily as a mucolytic agent—reducing the viscosity of mucus and promoting expectoration in respiratory tract infections. The "AJI 92" specification refers to its compliance with the purity standards established by Ajinomoto's amino acid quality benchmarks, ensuring it meets stringent pharmaceutical-grade quality control for active pharmaceutical ingredients (APIs). It is widely used in oral syrups, tablets, and granules in both human and veterinary medicine.
Doxycycline Hyclate BP
Doxycycline Hyclate BP is a broad-spectrum, semisynthetic tetracycline-class antibiotic available as the hemihydrate salt form of doxycycline. It is widely used in pharmaceutical formulations due to its high bioavailability, broad antibacterial activity, and favorable pharmacokinetic profile. The compound exhibits bacteriostatic action by inhibiting protein synthesis in susceptible bacteria, making it effective against a wide range of Gram-positive and Gram-negative organisms as well as atypical pathogens. It is typically supplied as a fine, white to off-white crystalline powder soluble in water and suitable for oral and parenteral dosage forms.
Guaiphenesin BP
Guaiphenesin BP is a white crystalline powder or granules with a faint characteristic odor, classified as an expectorant used primarily in pharmaceutical formulations to relieve chest congestion. It works by loosening and thinning mucus in the airways, making it easier to cough up and clear from the respiratory tract. It is widely utilized in cough syrups, tablets, and cold remedies. Recognized for its mucolytic and muscle-relaxant properties, Guaiphenesin is included in both prescription and over-the-counter medications worldwide.
Hydrocortisone Acetate
Hydrocortisone Acetate is a synthetic corticosteroid ester derived from hydrocortisone (cortisol). It is a white to off-white crystalline powder, practically insoluble in water but soluble in alcohol and acetone. This compound exhibits potent anti-inflammatory, immunosuppressive, and anti-allergic properties, making it widely used in pharmaceutical and dermatological formulations. Hydrocortisone Acetate acts by modulating gene expression to reduce the production of inflammatory mediators, thereby alleviating symptoms in various inflammatory and autoimmune conditions.
Ivermectin BP Vet
Ivermectin BP Vet is a potent, broad-spectrum antiparasitic agent widely used in veterinary medicine. It belongs to the avermectin family and works by disrupting nerve and muscle function in parasites, leading to paralysis and death. Ivermectin is highly effective against a range of internal and external parasites, including gastrointestinal worms, lungworms, mites, lice, and certain ticks. Available in oral, injectable, and topical forms, it is trusted for use in livestock, poultry, and companion animals. Its reliable efficacy, wide safety margin, and ease of administration make it an essential treatment in animal health and parasite control programs.
Mebendazole USP ( Micronized white)
Mebendazole USP (Micronized White) is a pharmaceutical-grade anthelmintic agent used for the treatment of parasitic worm infections. The micronized white powder form offers enhanced bioavailability and better dispersion in pharmaceutical formulations. It is effective against a broad spectrum of intestinal parasites including roundworms, whipworms, hookworms, and pinworms. Mebendazole is commonly used in oral tablet and suspension preparations, ensuring efficient parasite eradication with minimal side effects.
Miconazole Nitrate BP
Miconazole Nitrate BP is a high-purity, pharmaceutical-grade antifungal agent conforming to British Pharmacopoeia (BP) specifications. It is widely used in the formulation of topical and oral pharmaceutical products for the treatment of fungal infections caused by dermatophytes and yeasts, including Candida species. Miconazole Nitrate functions by inhibiting the biosynthesis of ergosterol, a vital component of fungal cell membranes, leading to cell death.
This white to off-white crystalline powder is highly effective and exhibits broad-spectrum antifungal and some antibacterial activity. It is commonly utilized in creams, ointments, powders, and gel formulations.
Neomycin Sulphate BP Oral
Neomycin Sulphate BP Oral is an aminoglycoside antibiotic derived from Streptomyces fradiae. It is used primarily for treating infections caused by susceptible aerobic gram-negative and some gram-positive bacteria. The oral form is especially utilized for intestinal antisepsis, to reduce bacterial flora before gastrointestinal surgery, or to treat hepatic encephalopathy by decreasing ammonia-producing bacteria in the gut. It is available in powder or tablet form conforming to British Pharmacopoeia (BP) standards, ensuring high purity and efficacy.
