Trimethoprim BP Micronised
Trimethoprim BP Micronised is a high-purity, fine powdered form of trimethoprim, an antibiotic used primarily for its bacteriostatic properties. The micronisation process enhances its solubility and bioavailability, making it more effective in pharmaceutical formulations. Trimethoprim acts by inhibiting bacterial dihydrofolate reductase, thereby preventing bacterial DNA synthesis and growth. It is widely used alone or in combination therapies to treat a variety of bacterial infections.
Primary Uses
Pharmaceutical Industry:
Active pharmaceutical ingredient (API) in oral tablets, suspensions, and injectable formulations targeting urinary tract infections (UTIs), respiratory tract infections, and other bacterial infections.
Used in combination with sulfamethoxazole (co-trimoxazole) for synergistic antibacterial effect.
Secondary Uses
Veterinary Medicine:
Incorporated in veterinary antibiotic formulations to treat bacterial infections in livestock and companion animals.
Research & Development:
Utilized in pharmaceutical research for developing new antibacterial drugs and formulations.
Chemical Name (IUPAC): 5-[(3,4,5-Trimethoxyphenyl)methyl]pyrimidine-2,4-diamine
Common/Trade Name: Trimethoprim BP Micronised
CAS Number: 738-70-5
HS Code: 2934.99.90
Synonyms: Trimethoprim, 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine
Physical & Chemical Properties
Physical State: Fine crystalline powder
Color & Odor: White to off-white; odorless
Particle Size: Micronised to enhance solubility and bioavailability
Melting Point: 199–201 °C
Solubility: Slightly soluble in water; soluble in alcohol and organic solvents
Purity: Complies with British Pharmacopoeia (BP) standards
Safety & Hazard Attributes
GHS Classification: Not classified as hazardous under normal handling
Toxicity: Low toxicity but may cause hypersensitivity or allergic reactions
Exposure Limits: Follow pharmaceutical industry safety guidelines
Storage & Handling Attributes
Storage Conditions: Store in a cool, dry, well-ventilated place away from light and moisture
Container Type: Sealed, moisture-proof containers such as HDPE drums or bottles
Shelf Life: Typically 24 months under recommended storage conditions
Handling Precautions: Avoid inhalation of dust; use appropriate PPE including masks and gloves
Regulatory & Compliance Attributes
Complies with British Pharmacopoeia (BP) standards
Manufactured under Good Manufacturing Practices (GMP) ensuring pharmaceutical-grade quality
Registered with relevant regulatory bodies for pharmaceutical use
Environmental & Health Impact
Biodegradability: Not readily biodegradable; follow waste disposal regulations
Ecotoxicity: Potentially harmful to aquatic organisms; avoid release into environment
Bioaccumulation: Not significant
PPE Required: Dust mask, gloves, and eye protection recommended during handling
Handling Guidelines: Use in well-ventilated areas; avoid dust generation
Storage Measures: Keep containers tightly closed and protected from moisture
First Aid Measures
Inhalation: Remove to fresh air; seek medical attention if symptoms develop
Skin Contact: Wash thoroughly with soap and water
Eye Contact: Rinse eyes with plenty of water; seek medical advice if irritation persists
Ingestion: Rinse mouth; seek immediate medical attention
Firefighting Measures
Fire Hazards: May burn but not easily ignitable
Extinguishing Media: Use water spray, foam, or dry chemical extinguisher
Hazardous Combustion Products: Carbon oxides and nitrogen oxides