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Trimethoprim BP Micronised

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Trimethoprim BP Micronised is a high-purity, fine powdered form of trimethoprim, an antibiotic used primarily for its bacteriostatic properties. The micronisation process enhances its solubility and bioavailability, making it more effective in pharmaceutical formulations. Trimethoprim acts by inhibiting bacterial dihydrofolate reductase, thereby preventing bacterial DNA synthesis and growth. It is widely used alone or in combination therapies to treat a variety of bacterial infections.

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Description

Primary Uses
Pharmaceutical Industry:

Active pharmaceutical ingredient (API) in oral tablets, suspensions, and injectable formulations targeting urinary tract infections (UTIs), respiratory tract infections, and other bacterial infections.

Used in combination with sulfamethoxazole (co-trimoxazole) for synergistic antibacterial effect.

Secondary Uses
Veterinary Medicine:

Incorporated in veterinary antibiotic formulations to treat bacterial infections in livestock and companion animals.

Research & Development:

Utilized in pharmaceutical research for developing new antibacterial drugs and formulations.

PRODUCT KEY FEATURES

Chemical Name (IUPAC): 5-[(3,4,5-Trimethoxyphenyl)methyl]pyrimidine-2,4-diamine

Common/Trade Name: Trimethoprim BP Micronised

CAS Number: 738-70-5

HS Code: 2934.99.90

Synonyms: Trimethoprim, 2,4-Diamino-5-(3,4,5-trimethoxybenzyl)pyrimidine

 

Physical & Chemical Properties
Physical State: Fine crystalline powder

Color & Odor: White to off-white; odorless

Particle Size: Micronised to enhance solubility and bioavailability

Melting Point: 199–201 °C

Solubility: Slightly soluble in water; soluble in alcohol and organic solvents

Purity: Complies with British Pharmacopoeia (BP) standards

 

Safety & Hazard Attributes
GHS Classification: Not classified as hazardous under normal handling

Toxicity: Low toxicity but may cause hypersensitivity or allergic reactions

Exposure Limits: Follow pharmaceutical industry safety guidelines

 

Storage & Handling Attributes
Storage Conditions: Store in a cool, dry, well-ventilated place away from light and moisture

Container Type: Sealed, moisture-proof containers such as HDPE drums or bottles

Shelf Life: Typically 24 months under recommended storage conditions

Handling Precautions: Avoid inhalation of dust; use appropriate PPE including masks and gloves

 

Regulatory & Compliance Attributes
Complies with British Pharmacopoeia (BP) standards

Manufactured under Good Manufacturing Practices (GMP) ensuring pharmaceutical-grade quality

Registered with relevant regulatory bodies for pharmaceutical use

 

Environmental & Health Impact
Biodegradability: Not readily biodegradable; follow waste disposal regulations

Ecotoxicity: Potentially harmful to aquatic organisms; avoid release into environment

Bioaccumulation: Not significant

SAFETY HANDLING PRECAUTIONS

PPE Required: Dust mask, gloves, and eye protection recommended during handling

Handling Guidelines: Use in well-ventilated areas; avoid dust generation

Storage Measures: Keep containers tightly closed and protected from moisture

 

First Aid Measures
Inhalation: Remove to fresh air; seek medical attention if symptoms develop

Skin Contact: Wash thoroughly with soap and water

Eye Contact: Rinse eyes with plenty of water; seek medical advice if irritation persists

Ingestion: Rinse mouth; seek immediate medical attention

 

Firefighting Measures
Fire Hazards: May burn but not easily ignitable

Extinguishing Media: Use water spray, foam, or dry chemical extinguisher

Hazardous Combustion Products: Carbon oxides and nitrogen oxides

 

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