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Vitamin B1 (Mono Nitrate BP)
Vitamin B1 Mononitrate BP is a stable, synthetic derivative of vitamin B1 (thiamine) used extensively in pharmaceutical, nutraceutical, and food fortification applications. It serves as an essential nutrient involved in carbohydrate metabolism and nervous system function. The mononitrate form offers enhanced stability and bioavailability compared to pure thiamine, making it ideal for inclusion in tablets, capsules, powders, and fortified food products.
Vitamin B1 (Mono Nitrate BP)
Primary Uses
- Pharmaceutical Industry
- Nutritional Supplement: Used in oral tablets, capsules, and injectables to prevent or treat thiamine deficiency and related disorders such as beriberi and Wernicke-Korsakoff syndrome.
- Neurological Support: Incorporated in formulations supporting nerve health and energy metabolism.
- Food & Beverage Industry
- Fortification Agent: Added to flour, cereals, beverages, and other food products to enhance nutritional content and prevent deficiency.
- Nutraceuticals & Dietary Supplements
- Included in multivitamin and B-complex supplements to support overall health and metabolic function.
Secondary Uses
- Animal Nutrition
- Feed Additive: Supplemented in animal feed to improve growth, appetite, and neurological health in livestock and pets.
- Cosmetic Industry
- Skin Health: Occasionally used in topical formulations for promoting skin vitality and repair, though limited.
- Research & Development
- Used in biochemical and nutritional studies involving vitamin B1 metabolism and deficiency.
1. Basic Identification Attributes
- Chemical Name (IUPAC): 3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium mononitrate
- Common/Trade Name: Vitamin B1 Mononitrate BP
- CAS Number: 532-43-4
- HS Code: 2936.21.00
- Synonyms: Thiamine mononitrate, vitamin B1 nitrate
2. Physical & Chemical Properties
- Physical State: Fine, white to off-white crystalline powder
- Color & Odor: White to off-white; odorless or faint characteristic odor
- Solubility: Soluble in water and alcohol
- Melting Point: 210-214 °C (decomposes)
- Density: Approx. 1.5 g/cm³
3. Safety & Hazard Attributes
- GHS Classification: Not classified as hazardous under normal use
- Toxicity: Low toxicity; safe within recommended dosages
- Exposure Limits: No specific occupational exposure limits established
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry, well-ventilated area away from light and moisture
- Container Type: Sealed bags or containers, moisture-proof packaging preferred
- Shelf Life: 24 months under proper storage conditions
- Handling Precautions: Avoid dust formation and inhalation; use PPE if necessary
5. Regulatory & Compliance Attributes
- Complies with British Pharmacopoeia (BP) standards
- Manufactured under GMP conditions for pharmaceutical grade quality
- Approved for use in food fortification, dietary supplements, and pharmaceuticals
- Meets international regulatory requirements for vitamin B1 products
6. Environmental & Health Impact
- Biodegradability: Biodegradable and environmentally safe under normal conditions
- Ecotoxicity: Low environmental risk
- Bioaccumulation: Not significant
Safety Handling Precautions
- PPE Required: Gloves and dust mask recommended during handling
- Handling Guidelines: Use in well-ventilated areas to minimize dust exposure
- Storage Measures: Keep container tightly closed and dry
First Aid Measures
- Inhalation: Move to fresh air; seek medical advice if symptoms persist
- Skin Contact: Wash with soap and water
- Eye Contact: Flush with water for 15 minutes; seek medical help if irritation persists
- Ingestion: Rinse mouth; seek medical advice if large amounts ingested
Firefighting Measures
- Fire Hazards: Not highly flammable but combustible
- Extinguishing Media: Use water spray, foam, or dry chemical extinguishers
- Hazardous Combustion Products: May produce carbon oxides and nitrogen oxides on burning
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