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Vitamin B5 (d-pantothenate)

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Vitamin B5 d-pantothenate, commonly referred to as D-Pantothenate, is the biologically active, water-soluble form of pantothenic acid. It is an essential nutrient involved in the synthesis of coenzyme A (CoA), critical for fatty acid metabolism and energy production. D-Pantothenate is used across pharmaceuticals, food, feed, cosmetics, and nutraceuticals due to its stability, bioavailability, and broad health benefits.

Description

Vitamin B5 (d-pantothenate)

Primary Uses 

  1. Pharmaceutical Industry
  • Nutritional Supplement: Formulated in tablets, capsules, and injectables to treat or prevent pantothenic acid deficiency, fatigue, irritability, and digestive disorders.
  • Wound Healing Support: Incorporated in treatments for skin disorders, burns, and post-surgical healing due to its tissue regeneration properties.
  1. Nutraceuticals & Dietary Supplements
  • Energy Metabolism: Used in B-complex vitamins to aid in energy release from carbohydrates, fats, and proteins.
  • Stress and Adrenal Support: Marketed in supplements targeting adrenal gland health and stress resilience.
  1. Food & Beverage Industry
  • Fortification Agent: Added to processed foods (e.g., cereals, beverages, infant formulas) to improve nutritional value and prevent deficiencies in the general population.

Secondary Uses 

  1. Cosmetics & Personal Care
  • Skin Care: Used in creams, lotions, and ointments for its moisturizing, soothing, and anti-inflammatory effects.
  • Hair Care: Found in shampoos, conditioners, and hair tonics to improve hair texture, strength, and manageability.
  • Nail Products: Occasionally used in nail care formulas to strengthen brittle nails.
  1. Animal Nutrition
  • Feed Additive: Added to livestock and poultry feed to promote growth, reproductive health, and immune system support.
  • Pet Food Fortification: Included in pet supplements to support coat health, metabolism, and vitality.
  1. Veterinary Medicine
  • Deficiency Treatment: Used to address metabolic disorders or deficiencies in animals, especially under stress or poor dietary conditions.
  1. Research & Development
  • Metabolic Studies: Used in laboratory research to study CoA-related metabolic pathways and enzyme regulation.
  • Biotechnological Applications: Occasionally used in microbial cultures to support bacterial or yeast growth.
KEY PRODUCT FEATURES

1. Basic Identification Attributes

  • Chemical Name (IUPAC): (R)-N-(2,4-Dihydroxy-3,3-dimethylbutanoyl)-β-alanine calcium salt (often as calcium D-pantothenate)
  • Common/Trade Name: D-Pantothenate, Calcium D-Pantothenate, Vitamin B5
  • CAS Number: 137-08-6 (for calcium D-pantothenate)
  • HS Code: 2936.26.00
  • Synonyms: Pantothenic acid calcium salt, Vitamin B5, Panthenol precursor

2. Physical & Chemical Properties

  • Physical State: White, hygroscopic powder
  • Color & Odor: White; odorless or faint characteristic odor
  • Solubility: Soluble in water; slightly soluble in alcohol
  • Melting Point: Decomposes above 190 °C
  • Density: Approx. 1.2 g/cm³
  • pH (1% solution): 6.8–8.0

3. Safety & Hazard Attributes

  • GHS Classification: Not classified as hazardous
  • Toxicity: Low toxicity; well-tolerated in humans and animals at recommended dosages
  • Exposure Limits: No established occupational limits

4. Storage & Handling Attributes

  • Storage Conditions: Store in a cool, dry place away from direct sunlight and moisture
  • Container Type: Sealed, light-resistant packaging
  • Shelf Life: 24 months under controlled storage
  • Handling Precautions: Avoid dust generation; handle in a well-ventilated environment

5. Regulatory & Compliance Attributes

  • Complies with: USP, BP, Ph. Eur. standards
  • Manufacturing Standards: GMP-compliant production
  • Food Use Approvals: Approved for use in food and beverage fortification
  • Supplement Use: Permitted in nutritional supplements globally
  • Animal Feed Compliance: Meets international standards for livestock and pet feed inclusion

6. Environmental & Health Impact

  • Biodegradability: Readily biodegradable
  • Ecotoxicity: Low environmental toxicity
  • Bioaccumulation: Not bioaccumulative
SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

  • PPE Required: Gloves and dust mask recommended
  • Handling Guidelines: Use under dry conditions with local exhaust ventilation
  • Storage Measures: Keep container tightly closed and protected from humidity

First Aid Measures

  • Inhalation: Move to fresh air; seek medical attention if discomfort persists
  • Skin Contact: Wash thoroughly with water and soap
  • Eye Contact: Flush with clean water for at least 15 minutes; seek medical advice if irritation occurs
  • Ingestion: Rinse mouth; consult a physician if large quantities are consumed

Firefighting Measures

  • Fire Hazards: Non-flammable but may decompose on heating
  • Extinguishing Media: Use dry chemical, CO₂, or water spray
  • Hazardous Combustion Products: Carbon oxides and nitrogen compounds may be released during combustion