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Glycerin Drum USP
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Glycerin Drum USP, also known as glycerol, is a high-purity, pharmaceutical-grade trihydroxy alcohol (triol) used extensively in pharmaceutical, cosmetic, food, and personal care industries. Supplied in 250kg HDPE drums, this grade complies with the standards of the United States Pharmacopeia (USP), ensuring suitability for internal and topical human use. It is a clear, colorless, odorless, viscous liquid with a sweet taste and hygroscopic (moisture-attracting) properties. USP glycerin is derived from natural or synthetic sources and serves as a solvent, humectant, emollient, sweetener, and preservative in various applications.
Description
Glycerin Drum USP
Primary UsesÂ
- Pharmaceutical & Medical Industry
- Excipient in oral medications like syrups, elixirs, and suspensions to improve texture and stability.
- Laxative agent in oral or rectal formulations (e.g., suppositories and enemas) due to its osmotic action.
- Solvent and stabilizer in injectables, eye drops, and topical drugs.
- Vehicle for active pharmaceutical ingredients (APIs) to aid delivery and bioavailability.
- Humectant and base in creams, gels, ointments, and transdermal patches.
- Preservative and plasticizer in soft gelatin capsules, lozenges, and tablets.
- Used in wound care gels and oral hygiene formulations like mouthwashes and toothpaste.
- Personal Care & Cosmetics
- Moisturizer and skin-conditioning agent in lotions, face creams, serums, and shaving products.
- Hydration enhancer for hair care formulations like shampoos, conditioners, and leave-in treatments.
- Improves spreadability, texture, and shelf life of skin and body care products.
- Humectant in soaps, helping maintain moisture balance and skin softness.
- Used in deodorants, hand sanitizers, and facial masks to enhance comfort and performance.
- Food & Beverage (Food-Contact Use Only)
- As a processing aid or indirect additive in manufacturing food-contact pharmaceuticals and dietary supplements.
- Carrier and stabilizer for botanical extracts and active ingredients in nutraceuticals.
- Used in glycerite formulations as a sugar-free alternative to alcohol-based tinctures.
- Nutraceutical & Supplement Industry
- Filler and carrier in liquid herbal products, vitamin drops, and functional beverages.
- Enhances taste and viscosity in sugar-free, natural health products.
- Serves as a capsule plasticizer in soft gels and vegetarian capsules.
Secondary UsesÂ
- Veterinary Applications
- Topical base and humectant in pet skin care products and creams.
- Laxative and solvent for veterinary formulations and feed supplements.
- Laboratory & Biotech
- Cryoprotectant in biological research for preserving cells, enzymes, and tissues during freezing.
- Used in gel electrophoresis buffers and media preparations.
- Industrial Applications (Restricted to Indirect Use)
- Lubricant in machinery where incidental food or drug contact may occur.
- Plasticizer in capsules, film coatings, and biodegradable polymers.
- Humectant and viscosity modifier in adhesives and coatings used in pharmaceutical packaging.
PRODUCT KEY FEATURES
- Basic Identification Attributes
- Chemical Name (IUPAC): Propane-1,2,3-triol
- Common/Trade Name: Glycerin / Glycerol (USP Grade)
- CAS Number: 56-81-5
- HS Code: 2905.45.00
- Molecular Formula: C₃H₈O₃
- Molecular Weight: 92.09 g/mol
- Synonyms:
- Glycerol
- 1,2,3-Propanetriol
- Trihydroxypropane
- Glycerin USP
- Glycerin Refined Grade
- Glycerolum
- Physical & Chemical Properties
- Physical State: Viscous liquid
- Color & Odor: Colorless, odorless, sweet-tasting
- Purity: ≥ 99.7% (USP standard)
- Boiling Point: 290 °C
- Melting Point: 18 °C
- Density: ~1.26 g/cm³ at 20 °C
- Solubility: Fully miscible in water and alcohol; insoluble in oils
- Refractive Index: ~1.473
- pH (in solution): ~7 (neutral)
- Viscosity (25°C): ~1,200 cP
- Safety & Hazard Attributes
- GHS Classification:
- Not hazardous under GHS for standard use
- NFPA Ratings:
- Health: 0
- Flammability: 1
- Reactivity: 0
- Toxicity: Very low; recognized as safe (GRAS)
- Allergenicity: Hypoallergenic; no known sensitization effects
- Storage & Handling Attributes
- Container Type: 250 kg HDPE drum or stainless steel container
- Storage Conditions:
- Store in a tightly sealed container
- Keep in cool (15–25 °C), dry, and well-ventilated areas
- Shelf Life: 24–36 months under recommended conditions
- Handling Notes:
- Hygroscopic—keep sealed to avoid water absorption
- Clean spills immediately (slippery)
- Regulatory & Compliance Attributes
- USP Monograph Compliant – For pharmaceutical and medical use
- FDA Approved – GRAS status and allowed in drugs, cosmetics, and foods
- Food Codex: Compliant as food contact material
- REACH Registered & RoHS Compliant
- Kosher/Halal Certified (depending on source)
- Free from GMOs, allergens, gluten, and animal derivatives (if vegetable-derived)
- Environmental & Health Impact
- Biodegradability: Fully biodegradable under aerobic and anaerobic conditions
- Ecotoxicity: Low risk to aquatic environments
- Bioaccumulation: Not expected
- Carcinogenicity/Mutagenicity: Not classified; no evidence of cancer risk
- Sustainability: Often sourced from renewable vegetable oils (e.g., palm, coconut, soy)
SAFETY HANDLING PRECAUTIONS
- Safety Handling Precautions
PPE Required:
- Nitrile gloves
- Safety goggles
- Apron (bulk handling)
Handling Guidelines:
- Avoid contact with eyes
- Prevent contamination by using clean equipment
- Use in well-ventilated areas if heating
Hygiene Practices:
- Wash hands thoroughly after handling
- Do not eat or drink while handling
- First Aid Measures
- Skin Contact: Wash with water and soap if irritation develops
- Eye Contact: Rinse thoroughly with clean water for at least 15 minutes
- Inhalation: Non-hazardous; move to fresh air if mist is inhaled in large volumes
- Ingestion: Safe in typical use levels; in case of large accidental ingestion, consult a physician
- Firefighting Measures
- Fire Hazards: Slightly flammable at high temperatures
- Flash Point: ~160 °C (closed cup)
- Extinguishing Media: Foam, COâ‚‚, dry chemical, or water spray
- Combustion Products: Carbon dioxide, carbon monoxide
- Firefighter PPE: Standard fire gear and SCBA if vapors are present
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