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Guaiphenesin BP
Guaiphenesin BP is a white crystalline powder or granules with a faint characteristic odor, classified as an expectorant used primarily in pharmaceutical formulations to relieve chest congestion. It works by loosening and thinning mucus in the airways, making it easier to cough up and clear from the respiratory tract. It is widely utilized in cough syrups, tablets, and cold remedies. Recognized for its mucolytic and muscle-relaxant properties, Guaiphenesin is included in both prescription and over-the-counter medications worldwide.
Guaiphenesin BP
Primary UsesÂ
- Pharmaceutical Industry
- Acts as an expectorant in cough syrups and cold medicines, aiding in mucus clearance in conditions such as bronchitis, common cold, and upper respiratory tract infections.
- Used in combination formulations with decongestants, antihistamines, and cough suppressants to provide symptomatic relief from cough and chest congestion.
- Formulated in tablet, capsule, and liquid dosage forms for oral administration.
- Employed as a muscle relaxant to alleviate minor muscle aches associated with respiratory illnesses.
- Utilized in veterinary medicine for respiratory conditions in animals.
- Cosmetics and Personal Care
- Occasionally used in topical formulations for its muscle-relaxant properties to relieve minor muscular discomfort.
- Research and Development
- Used as a standard reference compound in respiratory pharmacology studies and cough reflex research.
Secondary Uses
- Food Industry
- Sometimes included in formulations as a food-grade mucolytic additive in specialized functional foods targeting respiratory health.
- Industrial Applications
- Utilized in the synthesis of related pharmaceutical compounds as an intermediate or additive.
1. Basic Identification Attributes
- Chemical Name (IUPAC): 3-(2-Methoxyphenoxy)propane-1,2-diol
- Common/Trade Name: Guaiphenesin
- CAS Number: 93-14-1
- BP Reference: British Pharmacopoeia (BP) grade
- HS Code: 2933.69.00
- Molecular Formula: C10H14O4
- Molecular Weight: 198.22 g/mol
- Synonyms:
- Guaifenesin
- Glyceryl guaiacolate
- 3-(2-Methoxyphenoxy)-1,2-propanediol
2. Physical & Chemical Properties
- Physical State: Crystalline powder or granules
- Color & Odor: White; faint characteristic odor
- Melting Point: 92–96 °C
- Solubility: Slightly soluble in water; soluble in ethanol and chloroform
- pH (1% solution): 5.5–7.5
- Stability: Stable under normal storage conditions
3. Safety & Hazard Attributes
- GHS Classification: Not classified as hazardous; low toxicity
- Toxicity: Low acute toxicity; safe at recommended doses
- Irritation: May cause mild skin or eye irritation in concentrated form
4. Storage & Handling Attributes
- Container Type: Sealed polyethylene or glass containers
- Storage Conditions: Store in a cool, dry place away from light and moisture
- Shelf Life: Typically 3–5 years under recommended conditions
- Handling Notes: Avoid dust generation; use in well-ventilated areas
5. Regulatory & Compliance Attributes
- Pharmacopoeia Standards: Complies with BP, USP, and EP monographs
- Regulatory Approval: Approved for use in pharmaceutical formulations globally
- REACH: Registered for industrial use
6. Environmental & Health Impact
- Biodegradability: Biodegradable under aerobic conditions
- Ecotoxicity: Low environmental toxicity
- Bioaccumulation: Not expected to bioaccumulate
- Carcinogenicity/Mutagenicity: No evidence of carcinogenic or mutagenic effects
Safety Handling Precautions
- PPE Required: Gloves, dust mask, safety goggles
- Handling Guidelines: Avoid inhalation of dust; avoid contact with skin and eyes
- Hygiene: Wash hands thoroughly after handling; do not eat or smoke in handling areas
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if respiratory irritation persists
- Skin Contact: Wash with soap and water; seek medical advice if irritation develops
- Eye Contact: Rinse eyes with plenty of water for 15 minutes; consult physician if irritation continues
- Ingestion: Rinse mouth; seek medical attention if large quantities ingested
Firefighting Measures
- Fire Hazards: Combustible solid
- Extinguishing Media: Water spray, foam, dry chemical, COâ‚‚
- Combustion Products: Carbon oxides and other toxic fumes
- Firefighter PPE: Use self-contained breathing apparatus and protective clothing
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