Ammonium Acetate
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Ammonium acetate is a white crystalline solid or granular powder that is highly soluble in water. It is the ammonium salt of acetic acid and commonly appears as a colorless, odorless compound. Ammonium acetate is widely used in laboratories, chemical synthesis, food industry, pharmaceuticals, and industrial applications due to its buffering capacity and ability to provide both ammonium and acetate ions in solution. It functions as a neutral salt and is valued for its role as a pH buffer, reagent, and stabilizer.
Ammonium Acetate
Primary Uses
- Buffering Agent in Biochemistry and Molecular Biology
- Used extensively as a buffering agent in biochemical applications, especially in nucleic acid and protein purification techniques such as DNA and RNA precipitation.
- Maintains pH stability in electrophoresis and chromatography.
- Helps stabilize enzyme activity during assays and molecular biology protocols.
- Chemical Synthesis
- Employed as a reagent in organic synthesis, for example, in the preparation of acetates and other chemical intermediates.
- Used in the manufacture of pharmaceuticals and dyes.
- Food Industry
- Functions as a food additive and acidity regulator (E264), used to control pH in processed foods and beverages.
- Acts as a stabilizer and preservative to extend shelf life.
- Often found in baking powders and gelatin preparations.
- Pharmaceutical Industry
- Utilized as an excipient or buffering agent in drug formulations to maintain pH stability and improve drug solubility and bioavailability.
- Sometimes used in intravenous fluids and injectable formulations.
- Textile Industry
- Used in textile printing and dyeing as a neutralizing agent and buffer.
- Helps in fixing dyes and improving color fastness.
Secondary Uses
- Analytical Chemistry
- Serves as a standard in titrations and analytical calibrations.
- Used in mass spectrometry as a volatile buffer to improve ionization and peak shape.
- Laboratory Uses
- Employed as a reagent for buffer solutions in chemical and biochemical labs.
- Used in some chemical experiments as a source of acetate and ammonium ions.
- Agriculture
- Occasionally used as a nitrogen source or soil conditioner, though less common compared to other ammonium salts.
- Cosmetics
- Incorporated in some cosmetic products as a pH adjuster and buffering agent.
1. Basic Identification Attributes
- Chemical Name (IUPAC): Ammonium acetate
- Common/Trade Names: Ammonium acetate
- CAS Number: 631-61-8
- HS Code: 2915.90.00
- Molecular Formula: C2H7NO2
- Synonyms: Acetic acid ammonium salt, Ammonium ethanoate
2. Physical & Chemical Properties
- Physical State: White crystalline powder or granules
- Color & Odor: Colorless to white, odorless or faint vinegar-like odor
- Melting Point: 114–117°C (decomposes)
- Boiling Point: Decomposes before boiling
- Density: ~1.175 g/cm³
- Solubility: Highly soluble in water (~290 g/L at 20°C), slightly soluble in alcohol
- pH Level: Neutral to slightly basic (~7–8 in aqueous solution)
- Vapor Pressure: Negligible
- Flash Point: Non-flammable
- Autoignition Temperature: N/A
- Stability: Stable under normal conditions
3. Safety & Hazard Attributes
- Hazard Class (GHS): Generally considered non-hazardous
- NFPA Ratings: Health 1, Flammability 0, Reactivity 0
- Exposure Limits: No established OSHA PEL or ACGIH TLV
- Reactivity: Stable, but decomposes with strong acids or bases releasing ammonia or acetic acid vapors
- Incompatible Materials: Strong oxidizers, strong acids, strong bases
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place away from moisture and incompatible materials
- Container Type: Plastic or glass containers, tightly sealed
- Shelf Life: Typically 2-3 years if stored properly
- Special Handling: Avoid dust generation; use in well-ventilated areas; wear PPE during handling
5. Regulatory & Compliance Attributes
- Regulatory Status: Approved for use in food and pharmaceuticals with restrictions
- Transportation: Not classified as hazardous; normal transport conditions apply
- Waste Disposal: Dispose according to local regulations; generally non-hazardous waste
6. Environmental & Health Impact
- Ecotoxicity: Low toxicity to aquatic organisms
- Persistence: Biodegradable
- Carcinogenicity: Not classified as carcinogenic
- Biodegradability: Readily biodegradable
Safety Handling Precautions
- PPE: Use gloves, safety goggles, and dust masks when handling powder to prevent skin, eye, and respiratory exposure.
- Handling: Avoid dust inhalation; work in well-ventilated areas.
- Storage: Keep containers tightly sealed and store in dry areas to prevent caking.
- Hygiene: Wash hands after use; avoid eating or drinking during handling.
First Aid Measures
- Inhalation: Move affected person to fresh air. Seek medical attention if irritation persists.
- Skin Contact: Wash with soap and water; seek medical advice if irritation develops.
- Eye Contact: Rinse immediately with water for at least 15 minutes; consult a doctor if irritation continues.
- Ingestion: Rinse mouth; drink water. Seek medical advice if large quantities are ingested.
Firefighting Measures
- Fire Hazards: Non-flammable; may decompose at high temperatures releasing ammonia and acetic acid vapors.
- Extinguishing Media: Use water spray, dry chemical, foam, or CO₂ to extinguish surrounding fire.
- Special Precautions: Firefighters should wear self-contained breathing apparatus (SCBA) due to possible toxic gases.
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