Bronopol Amaris Chemicals
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Bronopol

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Bronopol (2-Bromo-2-nitropropane-1,3-diol) is a water-soluble, white crystalline powder or granules with a slight odor. It is a synthetic antimicrobial agent widely used as a preservative in personal care products, pharmaceuticals, cosmetics, and industrial applications. Bronopol exhibits broad-spectrum bactericidal and fungicidal activity, making it effective against a wide range of microorganisms. It works by releasing active formaldehyde slowly, which disrupts microbial metabolism and reproduction.

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Description

Bronopol

Primary Uses

  1. Personal Care & Cosmetics
  • Used as a preservative in shampoos, conditioners, lotions, creams, and other cosmetic formulations to inhibit bacterial and fungal growth.
  • Helps extend shelf life and maintain product integrity by preventing microbial contamination.
  1. Pharmaceuticals
  • Employed as a preservative in topical pharmaceutical formulations such as ointments and eye drops.
  1. Industrial Applications
  • Used as a biocide in paper mills, cooling water systems, and other industrial water treatment to control microbial growth and biofilm formation.
  • Applied in leather tanning and textile processing to prevent microbial degradation.

Secondary Uses 

  1. Household Products
  • Incorporated in cleaning agents and detergents as a preservative and antimicrobial agent.
  1. Agriculture
  • Occasionally used in seed treatment formulations to control fungal contamination.
KEY PRODUCT FEATURES

1. Basic Identification Attributes

  • Chemical Name (IUPAC): 2-Bromo-2-nitropropane-1,3-diol
  • Common/Trade Name: Bronopol
  • CAS Number: 52-51-7
  • HS Code: 2924.99.90
  • Molecular Formula: C3H6BrNO4
  • Synonyms:
    • Bronopol
    • 2-Bromo-2-nitro-1,3-propanediol
    • BNPD

2. Physical & Chemical Properties

  • Physical State: Crystalline powder or granules
  • Color & Odor: White; slight characteristic odor
  • Melting Point: 130–132°C (decomposes)
  • Boiling Point: Not applicable (decomposes)
  • Density: Approx. 1.8 g/cm³
  • Solubility: Soluble in water; insoluble in most organic solvents
  • pH: Slightly acidic to neutral in aqueous solution
  • Stability: Stable under recommended storage; decomposes under alkaline conditions or heat

3. Safety & Hazard Attributes

  • Hazard Class (GHS): Skin irritant; may cause serious eye irritation; harmful if swallowed
  • NFPA Ratings:
    • Health: 2
    • Flammability: 1
    • Reactivity: 1
  • Exposure Limits: No specific OSHA limits; avoid inhalation and skin contact
  • Toxicity: Moderate toxicity; can cause skin sensitization and allergic reactions in some individuals
  • Reactivity: Reactive with strong acids, bases, and oxidizing agents

4. Storage & Handling Attributes

  • Storage Conditions: Store in a cool, dry, well-ventilated area away from incompatible substances
  • Container Type: Sealed plastic or glass containers, corrosion-resistant
  • Shelf Life: Typically 2–3 years if stored properly
  • Special Handling: Avoid dust formation; use PPE; handle in well-ventilated areas

5. Regulatory & Compliance Attributes

  • FDA Status: Approved for limited use in cosmetics and pharmaceuticals as a preservative
  • REACH Registration: Registered under EU regulations
  • Transportation: Not classified as hazardous for transport under normal conditions
  • Waste Disposal: Dispose of as chemical waste in accordance with local regulations

6. Environmental & Health Impact

  • Ecotoxicity: Moderately toxic to aquatic organisms; avoid release into waterways
  • Persistence: Degrades slowly in the environment
  • Bioaccumulation: Low potential for bioaccumulation
  • Carcinogenicity/Mutagenicity: Not classified as carcinogenic; some concern for mutagenicity at high concentrations
  • Biodegradability: Partial biodegradability under aerobic conditions
SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

Personal Protective Equipment (PPE):

  • Gloves
  • Protective goggles
  • Dust mask or respirator if dust exposure is likely
  • Protective clothing

Handling Measures:

  • Avoid inhalation, ingestion, and skin or eye contact
  • Use local exhaust ventilation to minimize dust
  • Work in well-ventilated areas

Storage Measures:

  • Keep containers tightly closed
  • Protect from moisture, heat, and incompatible materials

Hygiene Practices:

  • Wash hands thoroughly after handling
  • Do not eat, drink, or smoke in work areas

First Aid Measures

  • Inhalation: Move to fresh air; seek medical attention if breathing difficulties occur
  • Skin Contact: Wash immediately with soap and water; seek medical advice if irritation develops
  • Eye Contact: Rinse cautiously with water for at least 15 minutes; seek immediate medical attention
  • Ingestion: Do not induce vomiting; rinse mouth and seek medical attention immediately

Firefighting Measures

  • Fire Hazards: Combustible; emits toxic gases on decomposition
  • Extinguishing Media: Use water spray, foam, dry chemical, or COâ‚‚ as appropriate
  • Special Precautions: Firefighters should wear full protective gear and SCBA
  • Decomposition Products: May produce bromine, nitrogen oxides, and other toxic fumes when heated

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