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Calcium D-Panthothenate
Calcium D-Panthothenate is the calcium salt of D-pantothenic acid (vitamin B5), appearing as a white or off-white crystalline powder. It is a stable, water-soluble compound widely used as a dietary supplement and pharmaceutical ingredient to supply vitamin B5, essential for coenzyme A synthesis and normal metabolism of carbohydrates, proteins, and fats. Calcium D-Panthothenate supports adrenal function, wound healing, and nervous system health, and is frequently incorporated into multivitamins, nutritional supplements, fortified foods, and topical formulations.
Calcium D-Panthothenate
Primary Uses
- Pharmaceuticals & Nutritional Supplements
- Used as a vitamin B5 source in dietary supplements and multivitamin formulations to prevent or treat pantothenic acid deficiency.
- Incorporated in pharmaceutical products targeting metabolic support, adrenal insufficiency, and wound healing.
- Included in vitamin B-complex preparations for overall nutritional balance.
- Food & Beverage Industry
- Fortification agent in functional foods, energy drinks, and infant formulas to enhance nutritional value.
- Used as a food additive and nutritional supplement ingredient in health foods.
- Cosmetics & Personal Care
- Added to topical skin care products for its moisturizing, anti-inflammatory, and skin barrier-enhancing properties.
- Utilized in hair care products to improve hair strength and scalp health.
Secondary Uses
- Veterinary Medicine
- Employed as a vitamin supplement in animal feeds and veterinary nutritional products.
- Research & Development
- Used in biochemical and nutritional studies related to metabolism and coenzyme A biosynthesis.
1. Basic Identification Attributes
- Chemical Name (IUPAC): Calcium (2R)-2,4-dihydroxy-3,3-dimethylbutanoate
- Common/Trade Name: Calcium D-Panthothenate, Calcium Pantothenate
- CAS Number: 137-08-6
- HS Code: 2936.29.90
- Molecular Formula: C18H32CaN2O10
- Synonyms:
- Calcium Pantothenate
- Vitamin B5 Calcium Salt
- Ca-D-Pantothenate
- Calcium D-pantothenate USP
2. Physical & Chemical Properties
- Physical State: Fine crystalline powder or granules
- Color & Odor: White to off-white; odorless
- Melting Point: Approx. 120–130°C (decomposes)
- Boiling Point: Not applicable (decomposes)
- Density: Approx. 1.5 g/cm³
- Solubility: Soluble in water; sparingly soluble in ethanol
- pH: Slightly alkaline in aqueous solution (pH ~6–8)
- Stability: Stable under normal conditions; sensitive to light, moisture, and heat
3. Safety & Hazard Attributes
- Hazard Class (GHS): Generally regarded as safe (GRAS); low toxicity
- NFPA Ratings:
- Health: 0
- Flammability: 1
- Reactivity: 0
- Exposure Limits: No specific OSHA/ACGIH limits established
- Toxicity: Low; non-toxic at recommended doses
- Reactivity: Stable; avoid strong oxidizers and extreme pH
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place, protected from light and moisture
- Container Type: Airtight, moisture-resistant containers (e.g., HDPE or glass)
- Shelf Life: Typically 2–3 years if stored properly
- Special Handling: Use PPE if dusty; avoid inhalation and prolonged skin contact
5. Regulatory & Compliance Attributes
- FDA Status: Approved as a dietary supplement ingredient and food additive (Vitamin B5 source)
- Pharmacopoeia Compliance: Listed in USP, EP, and JP standards
- Transportation: Not classified as hazardous
- Waste Disposal: Dispose according to local regulations; non-hazardous
6. Environmental & Health Impact
- Ecotoxicity: Minimal environmental impact
- Persistence: Organic compound; biodegradable under normal conditions
- Bioaccumulation: Not expected to bioaccumulate
- Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic
- Biodegradability: Biodegradable
Safety Handling precautions
Personal Protective Equipment (PPE):
- Gloves
- Protective goggles
- Dust mask if powdery
Handling Measures:
- Avoid inhaling dust
- Handle in well-ventilated area
Storage Measures:
- Keep container tightly closed
- Protect from moisture and light
Hygiene Practices:
- Wash hands after handling
- Avoid eating or drinking during handling
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if irritation occurs
- Skin Contact: Wash with soap and water; seek medical advice if irritation develops
- Eye Contact: Rinse with plenty of water; consult physician if irritation persists
- Ingestion: Rinse mouth; seek medical advice if large amounts ingested
Firefighting Measures
- Fire Hazards: Combustible but not highly flammable
- Extinguishing Media: Use water spray, foam, dry chemical, or CO₂
- Special Precautions: Firefighters should wear protective gear
- Decomposition Products: May produce carbon oxides, nitrogen oxides under high heat
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