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Chlorocresol BP
Chlorocresol BP, also known as PCMC (Para-Chlorometa-Cresol), is a white to off-white crystalline powder with a characteristic phenolic odor. It is a chlorinated phenol derivative widely used as a broad-spectrum antimicrobial preservative. It exhibits effective bactericidal and fungicidal activity, making it a preferred preservative in pharmaceutical, cosmetic, and personal care products. Chlorocresol is valued for its stability, solubility in aqueous and alcoholic systems, and compatibility with various formulation types. It helps inhibit microbial growth, thereby enhancing product shelf life and safety.
Chlorocresol BP
Primary Uses
- Pharmaceuticals
- Used as a preservative in topical creams, ointments, lotions, and injectables to prevent bacterial and fungal contamination.
- Incorporated in ophthalmic solutions and ear drops for antimicrobial protection.
- Added to antiseptic formulations for enhanced efficacy against pathogens.
- Cosmetics & Personal Care
- Employed in skin care products, hair care formulations, and deodorants as a preservative.
- Used in bath preparations and mouthwashes to inhibit microbial growth.
Secondary Uses
- Veterinary Medicine
- Used in veterinary topical and ophthalmic products for antimicrobial protection.
- Industrial Applications
- Incorporated in some industrial antiseptic and cleaning products where microbial contamination control is needed.
1. Basic Identification Attributes
- Chemical Name (IUPAC): 4-Chloro-3-methylphenol
- Common/Trade Name: Chlorocresol BP, PCMC
- CAS Number: 59-50-7
- HS Code: 2907.30.00
- Molecular Formula: C7H7ClO
- Synonyms:
- Para-Chlorometa-Cresol
- Chlorocresol
- PCMC
2. Physical & Chemical Properties
- Physical State: Crystalline powder
- Color & Odor: White to off-white; characteristic phenolic odor
- Melting Point: 64–68°C
- Boiling Point: Approx. 240°C (decomposes)
- Density: ~1.35 g/cm³
- Solubility: Slightly soluble in water; soluble in ethanol, ether, and oils
- Stability: Stable under normal storage; sensitive to light and heat
3. Safety & Hazard Attributes
- Hazard Class (GHS): Harmful if swallowed or inhaled; irritant to skin and eyes
- NFPA Ratings:
- Health: 2
- Flammability: 2
- Reactivity: 0
- Exposure Limits: Avoid inhalation and prolonged skin contact; use adequate ventilation
- Toxicity: Moderate toxicity; may cause skin sensitization and irritation
- Reactivity: Stable but avoid strong oxidizers and acids
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry, dark place in tightly closed containers
- Container Type: Sealed glass or high-density polyethylene containers
- Shelf Life: Typically 2-3 years under proper conditions
- Special Handling: Use PPE including gloves, goggles, and protective clothing; avoid dust generation
5. Regulatory & Compliance Attributes
- Pharmacopoeial Status: Complies with British Pharmacopoeia (BP) standards
- FDA Status: Approved as a preservative in pharmaceuticals and cosmetics
- REACH Status: Registered under EU regulations
- Transportation: Not classified as hazardous under normal transport conditions
- Waste Disposal: Dispose according to local environmental and hazardous waste regulations
6. Environmental & Health Impact
- Ecotoxicity: Toxic to aquatic organisms; avoid release to waterways
- Persistence: Degrades slowly in the environment
- Bioaccumulation: Not expected to bioaccumulate significantly
- Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic
- Biodegradability: Moderate biodegradability under aerobic conditions
Safety Handling Precautions
- PPE: Chemical-resistant gloves, eye protection, lab coat, and respiratory protection if dust is present
- Handling: Avoid inhalation, skin, and eye contact; handle in well-ventilated areas
- Storage: Keep container tightly sealed and away from incompatible substances
- Hygiene: Wash hands after handling; do not eat, drink, or smoke in work areas
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if symptoms persist
- Skin Contact: Wash with soap and water; seek medical advice if irritation occurs
- Eye Contact: Flush immediately with water for 15 minutes; seek medical help
- Ingestion: Rinse mouth; do not induce vomiting; seek immediate medical attention
Firefighting Measures
- Fire Hazards: Combustible; may emit toxic fumes including chlorine-containing gases upon decomposition
- Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguishers
- Special Precautions: Firefighters should wear full protective gear and self-contained breathing apparatus
- Decomposition Products: Chlorine-containing gases, carbon monoxide, carbon dioxide
Related products
Benzyl Konium Chloride
Benzyl Konium Chloride (BAC) 50% is a quaternary ammonium compound with potent antimicrobial and disinfectant properties. It is a cationic surfactant widely used for its bactericidal, fungicidal, and virucidal effects. This clear to pale yellow liquid concentrate is highly soluble in water and is commonly used in healthcare, sanitation, and industrial hygiene applications. BAC 50% solutions serve as active ingredients in disinfectants, sanitizers, and antiseptics due to their effectiveness against a broad spectrum of microorganisms.
Bismuth Subgallate
Bismuth Subgallate is a pale yellow, odorless, tasteless powder composed of bismuth and gallic acid derivatives. It is widely used as an internal deodorant for controlling odor from flatulence and stool, especially in patients with gastrointestinal conditions or post-surgery stomas. It also serves as a mild astringent and has hemostatic properties, making it useful in wound care products. Due to its insolubility in water and stability, it is suited for oral and topical formulations.
Chloroxylenol BP
Chloroxylenol BP is a pale yellow to colorless crystalline solid with a mild phenolic odor. It is a broad-spectrum antimicrobial agent widely used for its bactericidal, fungicidal, and antiviral properties. Chemically known as 4-chloro-3,5-dimethylphenol, Chloroxylenol acts by disrupting microbial cell membranes and inhibiting enzyme systems, making it effective against many gram-positive and some gram-negative bacteria, fungi, and viruses. Its relatively low toxicity and skin irritation profile compared to other phenols have made it a preferred active ingredient in antiseptics, disinfectants, and preservative formulations across pharmaceutical, personal care, household, and industrial applications.
Dichlorophene Technical
Dichlorophene Technical (also known as 2,2'-Methylenebis(4-chlorophenol)) is a chlorinated phenolic compound used primarily as an antimicrobial agent and disinfectant. It appears as a white to pale yellow crystalline powder with a characteristic phenolic odor. Known for its potent bactericidal and fungicidal properties, Dichlorophene is widely used in pharmaceutical formulations, personal care products, and industrial disinfectants. The “Technical” grade refers to its industrial or bulk purity form used as a raw material in manufacturing.
Naphthalene Balls
Napthalene Balls are solid, crystalline balls made primarily of naphthalene, a white, volatile, aromatic hydrocarbon derived from coal tar or petroleum refining. Known for their strong, distinctive odor, naphthalene balls are widely used as moth repellents and deodorizing agents. Due to their sublimation property, they slowly vaporize at room temperature, releasing fumes that are toxic to moths and insects. They find broad applications in household pest control, industrial storage protection, and chemical manufacturing.
Potassium Iodide USP
Potassium Iodide USP is a high-purity inorganic halogenated salt that meets the strict quality and purity standards of the United States Pharmacopeia (USP). It appears as white crystalline granules or powder, is odorless, and has a characteristic saline taste. This pharmaceutical-grade compound is valued for its ability to act as a source of iodide ions, its high solubility in water, and its stability when properly stored. It is slightly hygroscopic and may become yellow upon prolonged exposure to air due to liberation of iodine, with light and moisture accelerating decomposition, requiring careful packaging and storage. Potassium Iodide USP is manufactured under current Good Manufacturing Practices (cGMP) and is suitable for human pharmaceutical applications, nutritional supplements, and other uses requiring the highest purity standards.
Propylparaben (Prop BH)
Prop BH, also known as Propylparaben or Propyl 4-Hydroxybenzoate, is an organic compound belonging to the paraben family of preservatives. It appears as colorless small crystals or a white crystalline powder with a characteristic mild odor and a slightly bitter taste. The compound is practically insoluble in cold water but readily soluble in alcohols, ethers, and other organic solvents. Propylparaben is widely recognized for its broad-spectrum antimicrobial activity, particularly effective against molds, yeasts, and bacteria. Propylparaben is manufactured for use as a preservative in various industrial applications and is not intended for direct human consumption without appropriate certification.
Santophene( 4-chloro-2-Benzyl phenol)
Santophene (4-chloro-2-benzylphenol) is a chlorinated phenolic compound used primarily as a biocide and preservative in various industrial applications. It exhibits strong antimicrobial properties, effectively controlling the growth of bacteria, fungi, and algae. This compound is widely applied in coatings, paints, wood preservation, and water treatment to protect materials from microbial degradation and extend their service life.
