Chloroxylenol BP (PCMX)

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Chloroxylenol (PCMX) is a pale yellow to colorless crystalline solid with a mild phenolic odor. It is a broad-spectrum antimicrobial agent widely used for its bactericidal, fungicidal, and antiviral properties. Chemically known as 4-chloro-3,5-dimethylphenol, Chloroxylenol acts by disrupting microbial cell membranes and inhibiting enzyme systems, making it effective against many gram-positive and some gram-negative bacteria, fungi, and viruses. Its relatively low toxicity and skin irritation profile compared to other phenols have made it a preferred active ingredient in antiseptics, disinfectants, and preservative formulations across pharmaceutical, personal care, household, and industrial applications.

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Category: Antiseptics and Disinfectants Tags: Chloroxylenol BP, Household disinfectants, PCMX (Para-Chloro-Meta-Xyleneol), Pharmaceutical disinfectant, Phenolic disinfectant, White to off-white crystalline powder

Description

Chloroxylenol BP (PCMX) Uses

Table of Contents

Primary Uses

Pharmaceuticals & Healthcare

Active ingredient in antiseptic solutions, surgical scrubs, medicated soaps, and wound cleansers for preventing infections.
Used in topical creams, ointments, and lotions for minor skin infections, cuts, abrasions, and fungal conditions.
Incorporated in mouthwashes and throat lozenges for antimicrobial and antiseptic benefits.
Utilized in hospital disinfectants and instrument sanitizers to reduce microbial contamination.

Household & Institutional Disinfectants

Key ingredient in surface disinfectants, floor cleaners, and sanitizing sprays for hospitals, clinics, and public spaces.
Used in hand washes and sanitizers to control spread of pathogens.
Incorporated in disinfectant wipes and cleaning products to maintain hygiene.

Personal Care Products

Included in deodorants and antiseptic skin cleansers to prevent bacterial growth and odor formation.
Used in formulations requiring broad antimicrobial activity and skin compatibility.

Secondary Uses

Veterinary Medicine

Used as an antiseptic and disinfectant in veterinary wound care and skin treatment products.

Industrial Applications

Added as a preservative and antimicrobial agent in paints, coatings, and cooling water systems to prevent microbial spoilage.
Used in wood preservatives to inhibit fungal decay and mold growth.

Agriculture

Employed in certain biocidal formulations to control microbial contamination.

Cosmetics

Used as a preservative and antimicrobial additive in shampoos, lotions, and other cosmetic products to extend shelf life and prevent contamination.

PRODUCT KEY FEATURES

Basic Identification Attributes

Chemical Name (IUPAC): 4-chloro-3,5-dimethylphenol
Common/Trade Name: Chloroxylenol, PCMX (Para-Chloro-meta-xylenol)
CAS Number: 88-04-0
HS Code: 2907.19.00
Molecular Formula: C8H9ClO
Synonyms:
- PCMX
- Para-chloro-meta-xylenol
- Chloroxylenol BP

Physical & Chemical Properties

Physical State: Crystalline solid or flakes
Color & Odor: Pale yellow to colorless; mild phenolic odor
Melting Point: 69–74°C
Boiling Point: Approximately 285°C (decomposes)
Density: 1.24 g/cm³ at 20°C
Solubility:
- Slightly soluble in water (~1.2 g/L at 20°C)
- Soluble in ethanol, ether, and other organic solvents
Stability: Stable under normal conditions; sensitive to light and strong oxidizers

Safety & Hazard Attributes

Hazard Class (GHS): Harmful if swallowed; skin and eye irritant
NFPA Ratings: Health 2, Flammability 2, Reactivity 0
Exposure Limits: No specific occupational limits; avoid inhalation and skin contact
Toxicity: Low to moderate toxicity; safe within recommended use levels
Reactivity: Stable; avoid mixing with strong oxidizers and acids

Storage & Handling Attributes

Storage Conditions: Store in cool, dry, well-ventilated area away from direct sunlight
Container Type: Amber glass or HDPE containers with tight seals
Shelf Life: 2–3 years when stored properly
Special Handling: Use PPE including gloves, goggles, and masks to avoid dust or vapor exposure

Regulatory & Compliance Attributes

Included in British Pharmacopoeia (BP) standards for antiseptics
Approved by global regulatory agencies for antiseptic and disinfectant use
Registered under REACH and other chemical safety frameworks
Transportation: Not classified as hazardous material for transport under normal conditions
Waste Disposal: Dispose according to local environmental regulations for phenolic substances

Environmental & Health Impact

Ecotoxicity: Moderately toxic to aquatic life; avoid environmental release
Persistence: Biodegradable under aerobic conditions, may persist anaerobically
Bioaccumulation: Low potential
Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic

Biodegradability: Readily biodegradable in the environment

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE: Chemical-resistant gloves, protective eyewear, lab coat/apron, respiratory protection when handling powders or aerosols
Handling: Avoid inhalation of dust or vapors; use in well-ventilated areas
Storage: Keep container tightly closed, away from heat, sparks, and sunlight
Hygiene: Wash hands thoroughly after use; avoid eating, drinking, or smoking during handling

First Aid Measures

Inhalation: Move victim to fresh air; provide oxygen if breathing is difficult; seek medical attention if symptoms persist
Skin Contact: Wash affected area with soap and water; seek medical advice if irritation occurs
Eye Contact: Rinse eyes thoroughly with water for at least 15 minutes; get medical help if irritation continues
Ingestion: Do not induce vomiting; seek immediate medical assistance

Firefighting Measures

Fire Hazards: Combustible solid; emits toxic fumes including chlorine-containing compounds and phenols when burned
Extinguishing Media: Use foam, dry chemical, or carbon dioxide extinguishers
Special Precautions: Firefighters should wear full protective gear and self-contained breathing apparatus (SCBA)
Decomposition Products: Carbon monoxide, carbon dioxide, hydrogen chloride, other toxic fumes