D-Panthenol USP

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D-Panthenol USP, also known as Provitamin B5, is the dextrorotatory isomer of panthenol and is biologically active. It is a water-soluble, viscous, clear liquid with a slightly sweet odor and is widely used in pharmaceutical, cosmetic, personal care, and nutraceutical applications. D-Panthenol is the alcohol analog of pantothenic acid (Vitamin B5) and is converted into Vitamin B5 in the skin and body, where it plays a vital role in cellular metabolism and tissue repair. Its moisturizing, anti-inflammatory, and healing properties make it highly valuable across industries.

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Categories: Active Ingredient, Nutraceutical Ingredients (pharmaceutical) Tags: Cosmetic ingredient, Cosmetic raw materials, D-Panthenol USP, DIY cosmetics, Panthenol, Pharmaceutical Grade, Pharmaceutical Ingredients

Description

Table of Contents

D-Panthenol USP

Primary Uses

Cosmetics & Personal Care

Used in skin care products (lotions, creams, serums) for its moisturizing, soothing, and anti-inflammatory properties.
Improves skin hydration, reduces redness, and enhances skin barrier repair.
Commonly found in shampoos, conditioners, and hair serums to improve hair strength, shine, and manageability.
A key ingredient in baby care products due to its mildness and skin-healing benefits.
Included in after-sun and burn relief products for its calming effects.

Pharmaceuticals

Used in wound healing creams, ointments, and gels for its epithelialization-promoting and anti-inflammatory actions.
Incorporated into nasal sprays, eye drops, and oral formulations for mucosal repair.
Applied in burn and dermatitis treatment formulations.
Serves as a humectant and skin protectant in topical drugs.

Nutraceuticals & Dietary Supplements

Used in vitamin formulations and fortified beverages as a source of Vitamin B5.
Supports adrenal function, cellular metabolism, and skin/mucosal health.

Secondary Uses

Veterinary Care

Used in veterinary skin creams and hair products for animals to promote healing and coat health.
Applied in topical ointments for livestock to treat minor wounds and dermatitis.

Industrial Applications

Used in industrial skin-care formulations (e.g., barrier creams for workers).
Added in formulations for protective creams used in occupational settings to treat or prevent irritant contact dermatitis.

Research & Biotechnology

Utilized in cell culture media and tissue engineering applications due to its role in cellular repair and proliferation.

KEY PRODUCT FEATURES

1. Basic Identification Attributes

Chemical Name (IUPAC): (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
Common/Trade Name: D-Panthenol USP
CAS Number: 81-13-0
HS Code: 2936.26.00
Molecular Formula: C9H19NO4
Synonyms:
- Provitamin B5
- Dexpanthenol
- Pantothenol

2. Physical & Chemical Properties

Physical State: Viscous liquid
Color & Odor: Colorless to slightly yellow; mild, characteristic odor
Melting Point: Not applicable (liquid form)
Boiling Point: ~118–120°C at 0.15 mmHg
Density: 1.145–1.160 g/cm³ at 20°C
Solubility:
- Freely soluble in water and alcohol
- Insoluble in oils and hydrocarbons
pH (10% solution): 5.0–7.0
Stability: Stable under recommended storage; sensitive to high heat and oxidizing agents

3. Safety & Hazard Attributes

Hazard Class (GHS): Not classified as hazardous
NFPA Ratings:
- Health: 0
- Flammability: 1
- Reactivity: 0
Exposure Limits: No established limits; generally considered safe
Toxicity: Non-toxic; well-tolerated on skin and mucosa
Reactivity: Non-reactive; avoid contact with strong oxidizers

4. Storage & Handling Attributes

Storage Conditions: Store in tightly sealed containers at 15–25°C, away from direct sunlight and heat
Container Type: Amber glass or HDPE containers with airtight seals
Shelf Life: Up to 3 years under optimal conditions
Special Handling: Use clean, dry tools; protect from contamination and moisture

5. Regulatory & Compliance Attributes

USP/NF Status: Complies with United States Pharmacopeia (USP) standards
FDA Status: GRAS (Generally Recognized as Safe); approved for cosmetic and pharmaceutical use
REACH Status: Registered under EU REACH
Transportation: Not classified as hazardous for transport
Waste Disposal: Dispose in accordance with local regulations; biodegradable and non-toxic

6. Environmental & Health Impact

Ecotoxicity: Not toxic to aquatic or terrestrial life
Persistence: Readily biodegradable
Bioaccumulation: Not expected to bioaccumulate
Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic
Biodegradability: High; environmentally safe for disposal

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

Personal Protective Equipment (PPE):

Nitrile gloves
Protective eyewear
Lab coat or apron

Handling Measures:

Avoid inhalation of vapors or aerosols during processing
Use in a well-ventilated area
Avoid contact with incompatible substances

Storage Measures:

Keep containers sealed and protected from light and air
Store in original packaging or approved chemical storage containers

Hygiene Practices:

Wash hands thoroughly after handling
Avoid contact with eyes and broken skin
Do not eat or drink in processing areas

First Aid Measures

Inhalation: Not expected to pose inhalation hazard; move to fresh air if discomfort occurs
Skin Contact: Generally non-irritating; rinse with water if needed
Eye Contact: Rinse with water for several minutes; seek medical attention if irritation persists
Ingestion: Non-toxic in small quantities; seek medical advice if large amounts are ingested

Firefighting Measures

Fire Hazards: Slightly combustible
Extinguishing Media: Use dry chemical, CO₂, water spray, or foam
Special Precautions: Firefighters should wear full protective gear and self-contained breathing apparatus
Decomposition Products: May release carbon oxides upon combustion