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D-Panthenol USP

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D-Panthenol USP, also known as Provitamin B5, is the dextrorotatory isomer of panthenol and is biologically active. It is a water-soluble, viscous, clear liquid with a slightly sweet odor and is widely used in pharmaceutical, cosmetic, personal care, and nutraceutical applications. D-Panthenol is the alcohol analog of pantothenic acid (Vitamin B5) and is converted into Vitamin B5 in the skin and body, where it plays a vital role in cellular metabolism and tissue repair. Its moisturizing, anti-inflammatory, and healing properties make it highly valuable across industries.

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Description

D-Panthenol USP

Primary Uses 

  1. Cosmetics & Personal Care
  • Used in skin care products (lotions, creams, serums) for its moisturizing, soothing, and anti-inflammatory properties.
  • Improves skin hydration, reduces redness, and enhances skin barrier repair.
  • Commonly found in shampoos, conditioners, and hair serums to improve hair strength, shine, and manageability.
  • A key ingredient in baby care products due to its mildness and skin-healing benefits.
  • Included in after-sun and burn relief products for its calming effects.
  1. Pharmaceuticals
  • Used in wound healing creams, ointments, and gels for its epithelialization-promoting and anti-inflammatory actions.
  • Incorporated into nasal sprays, eye drops, and oral formulations for mucosal repair.
  • Applied in burn and dermatitis treatment formulations.
  • Serves as a humectant and skin protectant in topical drugs.
  1. Nutraceuticals & Dietary Supplements
  • Used in vitamin formulations and fortified beverages as a source of Vitamin B5.
  • Supports adrenal function, cellular metabolism, and skin/mucosal health.

Secondary Uses

  1. Veterinary Care
  • Used in veterinary skin creams and hair products for animals to promote healing and coat health.
  • Applied in topical ointments for livestock to treat minor wounds and dermatitis.
  1. Industrial Applications
  • Used in industrial skin-care formulations (e.g., barrier creams for workers).
  • Added in formulations for protective creams used in occupational settings to treat or prevent irritant contact dermatitis.
  1. Research & Biotechnology
  • Utilized in cell culture media and tissue engineering applications due to its role in cellular repair and proliferation.
KEY PRODUCT FEATURES

1. Basic Identification Attributes

  • Chemical Name (IUPAC): (2R)-2,4-dihydroxy-N-(3-hydroxypropyl)-3,3-dimethylbutanamide
  • Common/Trade Name: D-Panthenol USP
  • CAS Number: 81-13-0
  • HS Code: 2936.26.00
  • Molecular Formula: C9H19NO4
  • Synonyms:
    • Provitamin B5
    • Dexpanthenol
    • Pantothenol

2. Physical & Chemical Properties

  • Physical State: Viscous liquid
  • Color & Odor: Colorless to slightly yellow; mild, characteristic odor
  • Melting Point: Not applicable (liquid form)
  • Boiling Point: ~118–120°C at 0.15 mmHg
  • Density: 1.145–1.160 g/cm³ at 20°C
  • Solubility:
    • Freely soluble in water and alcohol
    • Insoluble in oils and hydrocarbons
  • pH (10% solution): 5.0–7.0
  • Stability: Stable under recommended storage; sensitive to high heat and oxidizing agents

3. Safety & Hazard Attributes

  • Hazard Class (GHS): Not classified as hazardous
  • NFPA Ratings:
    • Health: 0
    • Flammability: 1
    • Reactivity: 0
  • Exposure Limits: No established limits; generally considered safe
  • Toxicity: Non-toxic; well-tolerated on skin and mucosa
  • Reactivity: Non-reactive; avoid contact with strong oxidizers

4. Storage & Handling Attributes

  • Storage Conditions: Store in tightly sealed containers at 15–25°C, away from direct sunlight and heat
  • Container Type: Amber glass or HDPE containers with airtight seals
  • Shelf Life: Up to 3 years under optimal conditions
  • Special Handling: Use clean, dry tools; protect from contamination and moisture

5. Regulatory & Compliance Attributes

  • USP/NF Status: Complies with United States Pharmacopeia (USP) standards
  • FDA Status: GRAS (Generally Recognized as Safe); approved for cosmetic and pharmaceutical use
  • REACH Status: Registered under EU REACH
  • Transportation: Not classified as hazardous for transport
  • Waste Disposal: Dispose in accordance with local regulations; biodegradable and non-toxic

6. Environmental & Health Impact

  • Ecotoxicity: Not toxic to aquatic or terrestrial life
  • Persistence: Readily biodegradable
  • Bioaccumulation: Not expected to bioaccumulate
  • Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic
  • Biodegradability: High; environmentally safe for disposal
SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

Personal Protective Equipment (PPE):

  • Nitrile gloves
  • Protective eyewear
  • Lab coat or apron

Handling Measures:

  • Avoid inhalation of vapors or aerosols during processing
  • Use in a well-ventilated area
  • Avoid contact with incompatible substances

Storage Measures:

  • Keep containers sealed and protected from light and air
  • Store in original packaging or approved chemical storage containers

Hygiene Practices:

  • Wash hands thoroughly after handling
  • Avoid contact with eyes and broken skin
  • Do not eat or drink in processing areas

First Aid Measures

  • Inhalation: Not expected to pose inhalation hazard; move to fresh air if discomfort occurs
  • Skin Contact: Generally non-irritating; rinse with water if needed
  • Eye Contact: Rinse with water for several minutes; seek medical attention if irritation persists
  • Ingestion: Non-toxic in small quantities; seek medical advice if large amounts are ingested

Firefighting Measures

  • Fire Hazards: Slightly combustible
  • Extinguishing Media: Use dry chemical, CO₂, water spray, or foam
  • Special Precautions: Firefighters should wear full protective gear and self-contained breathing apparatus
  • Decomposition Products: May release carbon oxides upon combustion

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