Hydrocortisone Acetate

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Hydrocortisone Acetate is a synthetic corticosteroid ester derived from hydrocortisone (cortisol). It is a white to off-white crystalline powder, practically insoluble in water but soluble in alcohol and acetone. This compound exhibits potent anti-inflammatory, immunosuppressive, and anti-allergic properties, making it widely used in pharmaceutical and dermatological formulations. Hydrocortisone Acetate acts by modulating gene expression to reduce the production of inflammatory mediators, thereby alleviating symptoms in various inflammatory and autoimmune conditions.

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Category: Active Pharmaceutical Ingredients (APIs) Tags: Anti-inflammatory, Corticosteroid, Hydrocortisone Acetate, Pharmaceutical ingredient, Topical Steroid

Description

Table of Contents

Hydrocortisone Acetate

Primary Uses

Pharmaceutical and Medical

Used extensively as an active pharmaceutical ingredient (API) in topical formulations (creams, ointments, lotions) for treating skin disorders such as eczema, psoriasis, dermatitis, and allergic reactions.
Applied in injectable formulations for systemic anti-inflammatory and immunosuppressive therapy.
Incorporated into ophthalmic preparations for managing eye inflammations.
Utilized in intramuscular or intralesional injections to treat localized inflammation and autoimmune diseases.
Plays a role in replacement therapy for adrenal insufficiency and certain endocrine disorders.

Veterinary Medicine

Used similarly in veterinary formulations to treat inflammatory and allergic conditions in animals.

Secondary Uses

Cosmetic Industry

Occasionally incorporated into dermatological cosmetic formulations for anti-inflammatory benefits in sensitive or problem skin products (with strict regulatory limits).

Biomedical Research

Utilized in experimental models to study inflammation, immune responses, and corticosteroid pharmacodynamics.
Used to investigate corticosteroid receptor interactions and gene expression pathways.

Combination Formulations

Combined with antibiotics, antifungals, or antiseptics in multi-action topical products for enhanced therapeutic effects.

KEY PRODUCT FEATURES

1. Basic Identification Attributes

Chemical Name (IUPAC): (11β)-11,17,21-Trihydroxypregn-4-ene-3,20-dione 21-acetate
Common/Trade Name: Hydrocortisone Acetate
CAS Number: 50-03-3
HS Code: 2937.29.00
Molecular Formula: C23H32O6
Synonyms: Cortisol acetate; Hydrocortisone 21-acetate; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-acetate

2. Physical & Chemical Properties

Physical State: Crystalline powder
Color & Odor: White to off-white; odorless or faint odor
Melting Point: 220–225 °C (decomposes)
Solubility: Practically insoluble in water; soluble in ethanol, acetone, and chloroform
Stability: Stable under recommended storage, sensitive to light and moisture

3. Safety & Hazard Attributes

GHS Classification: Not classified as hazardous under normal handling; potential irritant
Toxicity: Low acute toxicity; long-term use may cause systemic corticosteroid effects
Exposure Limits: No specific occupational limits, but good industrial hygiene is recommended

4. Storage & Handling Attributes

Container Type: Airtight, moisture-proof containers (glass or high-density polyethylene)
Storage Conditions: Store in a cool, dry, dark place, away from heat and direct sunlight
Shelf Life: Typically 24 months under recommended storage conditions
Handling Notes: Avoid inhalation of dust; use in well-ventilated areas

5. Regulatory & Compliance Attributes

Approved for pharmaceutical use globally (FDA, EMA, WHO monographs)
Controlled substance regulations vary by country due to corticosteroid properties
Usage strictly regulated in cosmetics due to potency and side effect profile

6. Environmental & Health Impact

Biodegradability: Expected to degrade in environment, but slow due to steroid structure
Ecotoxicity: Potential endocrine disruptor; should be managed to avoid environmental contamination
Bioaccumulation: Not expected significantly
Carcinogenicity/Mutagenicity: Not classified as carcinogenic

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE Required: Gloves, dust mask, protective eyewear if handling powder
Handling Guidelines: Use in well-ventilated areas, avoid generating dust, prevent skin and eye contact
Hygiene Practices: Wash hands after handling; avoid eating or smoking during use

First Aid Measures

Inhalation: Move to fresh air; seek medical advice if symptoms develop
Skin Contact: Wash thoroughly with soap and water; seek medical attention if irritation occurs
Eye Contact: Rinse eyes with plenty of water for at least 15 minutes; consult a doctor if irritation persists
Ingestion: Rinse mouth; seek medical attention for significant ingestion

Firefighting Measures

Fire Hazards: Combustible powder; emits toxic fumes including CO, CO₂, and other combustion products
Extinguishing Media: Water spray, foam, dry chemical, or CO₂
Special Precautions: Firefighters should wear protective equipment and self-contained breathing apparatus
Decomposition Products: Carbon oxides, steroid fragments