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Promethazine
Promethazine is a first-generation antihistamine with potent sedative, antiemetic, and anticholinergic properties. It is commonly used to treat allergic reactions, nausea, vomiting, motion sickness, and as a sedative or sleep aid. Its broad pharmacological effects make it valuable in both acute and chronic medical settings for symptom relief and prevention
Promethazine
Primary Uses
- Allergy Treatment
- Used to relieve symptoms of allergic conditions such as hay fever, urticaria, and rhinitis.
- Provides relief from itching, swelling, and rashes.
- Antiemetic Therapy
- Prevents and treats nausea and vomiting caused by motion sickness, surgery, chemotherapy, and radiation therapy.
- Sedation and Sleep Aid
- Utilized for its sedative effects to manage anxiety, insomnia, and preoperative sedation.
- Motion Sickness
- Administered to prevent and alleviate motion sickness symptoms.
Secondary Use
- Anaphylaxis Adjunct
- Used as part of emergency treatment to control allergic symptoms alongside epinephrine.
- Postoperative Nausea
- Employed to control nausea and vomiting following surgery.
- Adjunct in Pain Management
- Sometimes combined with analgesics to enhance pain relief and reduce nausea.
1. Basic Identification Attributes
- Chemical Name (IUPAC): N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
- Common/Trade Name: Promethazine
- CAS Number: 58-33-3
- HS Code: 2933.99
- Synonyms: Phenergan, Promethazine hydrochloride
2. Physical & Chemical Properties
- Physical State: White to off-white crystalline powder
- Color & Odor: Odorless to faint odor
- Solubility: Slightly soluble in water; soluble in alcohol and chloroform
- Melting Point: Approximately 214–217°C
3. Safety & Hazard Attributes
- GHS Classification: May cause sedation and dizziness; irritant to eyes and skin
- Toxicity: Moderate; use under medical supervision
- Exposure Limits: Follow occupational safety guidelines
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place, protected from light
- Container Type: Sealed glass or plastic containers
- Shelf Life: Typically 2–3 years
- Handling Precautions: Avoid inhalation and skin contact
5. Regulatory & Compliance Attributes
- Approved by major pharmacopeias (USP, BP)
- Regulated as a prescription medication
6. Environmental & Health Impact
- Biodegradability: Readily biodegradable under environmental conditions
- Ecotoxicity: Low when disposed properly
- Bioaccumulation: Not significant
Safety Handling Precautions
- PPE Required: Gloves recommended when handling powder or solutions
- Handling Guidelines: Use in well-ventilated areas; avoid direct contact
- Storage Measures: Keep containers tightly closed and protected from moisture
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if respiratory symptoms develop
- Skin Contact: Wash thoroughly with soap and water; seek medical advice if irritation persists
- Eye Contact: Rinse with water for 15 minutes; seek medical help if irritation continues
- Ingestion: Do not induce vomiting; seek emergency medical care immediately
Firefighting Measures
- Fire Hazards: Combustible under fire conditions
- Extinguishing Media: Water spray, foam, dry chemical, CO₂
- Special Precautions: Use protective equipment and breathing apparatus
- Hazardous Combustion Products: Carbon oxides and nitrogen oxides
Related products
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Cetirizine Hydrochloride is a widely used second-generation antihistamine effective for treating allergic conditions such as allergic rhinitis, chronic urticaria, and other allergy symptoms. It is the hydrochloride salt form of cetirizine, existing as a white to off-white crystalline powder with a slightly bitter taste. Cetirizine HCl acts by selectively blocking peripheral H1 histamine receptors, thereby reducing allergic symptoms without significant sedation or central nervous system depression. It is commonly formulated into tablets, syrups, and capsules as an active pharmaceutical ingredient.
Diphenhydramine HCL BP
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Guaiphenesin BP
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Hydrocortisone Base BP 93 Micro
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Ichthammol BP98
Ichthammol BP98, also known as ammonium bituminosulfonate, is a dark brown to black, viscous, sulfur-rich, semi-solid substance derived from the distillation of shale or bituminous rocks. It has a characteristic tar-like odor and is highly valued in pharmaceutical and dermatological applications for its anti-inflammatory, antiseptic, antipruritic (anti-itch), and keratolytic properties. Ichthammol penetrates deeply into the skin and soft tissues, helping to alleviate inflammation and promote healing. It is widely used in topical preparations for treating skin conditions such as eczema, psoriasis, boils, abscesses, and other dermatological infections.
Levamisole Hcl BP2000
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Lidocaine HCL BP
Lidocaine HCL BP is a white crystalline powder or granules that are highly soluble in water. It is a local anesthetic and antiarrhythmic agent widely used in medical and dental fields. Lidocaine HCL BP acts by blocking nerve signal transmission, providing rapid and effective numbing of targeted areas. It conforms to British Pharmacopoeia (BP) standards, ensuring pharmaceutical-grade purity and consistency. It is commonly formulated into injections, topical gels, creams, and patches for pain relief and arrhythmia treatment.
Piperazine Citrate BP
Piperazine Citrate BP is a pharmaceutical-grade anthelmintic compound used primarily for the treatment of intestinal worm infections, especially ascariasis (roundworms) and enterobiasis (pinworms). It works by paralyzing the worms, allowing them to be expelled naturally from the body through bowel movements. Piperazine Citrate is included in the British Pharmacopoeia (BP) and is known for its safety, efficacy, and wide use in both human and veterinary medicine.
