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Silver Sulphadiazine USP
Silver Sulphadiazine USP is a topical antimicrobial agent used primarily in the treatment and prevention of infections in burn wounds and other skin injuries. It combines the broad-spectrum antibacterial effects of silver ions with the antimicrobial properties of sulphadiazine, a sulfonamide antibiotic. This combination helps to prevent bacterial colonization and promotes healing by reducing the risk of infection. Silver Sulphadiazine is widely used in clinical and hospital settings and is available as a cream or ointment formulation meeting United States Pharmacopeia (USP) standards for purity and quality.
Silver Sulphadiazine USP
Primary Uses
- Medical & Pharmaceutical Applications
- Treatment and prevention of infections in second- and third-degree burns.
- Used to prevent sepsis and microbial colonization on burn wounds and skin grafts.
- Applied topically to chronic ulcers, pressure sores, and infected wounds.
- Used in surgical dressings and postoperative wound care to reduce infection risk.
- Employed in dermatological treatments for bacterial skin infections.
- Veterinary Medicine
- Used for treating wounds, burns, and skin infections in animals.
Secondary Uses
- Research & Development
- Used in microbiological studies investigating antimicrobial agents and resistance.
- Employed in formulation research for topical antimicrobial creams and dressings.
- Cosmetics & Personal Care
- Occasionally included in specialized wound healing or skin treatment products under medical supervision.
1. Basic Identification Attributes
- Chemical Name (IUPAC): Silver 4-amino-N-(pyrimidin-2-yl)benzene-1-sulfonamide-5-carboxamide
- Common/Trade Name: Silver Sulphadiazine USP
- CAS Number: 141-07-7
- HS Code: 2933.99
- Synonyms: SSD, Silvadene, Silver Sulfadiazine
2. Physical & Chemical Properties
- Physical State: Cream or ointment (typically 1% silver sulphadiazine)
- Color & Odor: White to off-white; odorless or faint medicinal odor
- Solubility: Slightly soluble in water; soluble in dilute alkali
- pH: Approximately 3.5–5.5 (cream)
- Stability: Stable under recommended storage conditions
3. Safety & Hazard Attributes
- GHS Clasification: Harmful if swallowed; may cause skin and eye irritation
- Toxicity: Low systemic toxicity when used topically; avoid ingestion and prolonged exposure
- Exposure Limits: Follow occupational safety guidelines for handling powders or creams
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place below 25°C, away from light and moisture
- Container Type: Tubes, jars, or aluminum laminate packaging for creams and ointments
- Shelf Life: Typically 24 months if stored properly
- Handling Precautions: Use gloves to avoid skin contact; avoid inhaling powder form
5. Regulatory & Compliance Attributes
- Complies with USP standards for pharmaceutical grade products
- Approved by FDA and equivalent regulatory bodies for topical burn treatment
- Manufactured in GMP-certified pharmaceutical facilities
6. Environmental & Health Impact
- Biodegradability: Silver compounds can be persistent; handle disposal with care
- Ecotoxicity: Toxic to aquatic life; avoid environmental release of large quantities
- Bioaccumulation: Silver ions may bioaccumulate; use in accordance with safety regulations
Safety Handling Precautions
- PPE Required: Gloves and eye protection recommended during handling
- Handling Guidelines: Avoid inhalation and prolonged skin contact; work in well-ventilated areas
- Storage Measures: Keep containers tightly closed and stored in a dry environment
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if respiratory irritation occurs
- Skin Contact: Wash affected area with soap and water; seek medical advice if irritation develops
- Eye Contact: Rinse immediately with plenty of water for at least 15 minutes; get medical help if irritation persists
- Ingestion: Rinse mouth; do not induce vomiting; seek immediate medical assistance
Firefighting Measures
- Fire Hazards: Non-flammable
- Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ for surrounding fires
- Special Precautions: Wear protective gear to avoid exposure to toxic fumes from packaging or additives
- Hazardous Combustion Products: May release toxic fumes including sulfur oxides and silver compounds
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