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Tripotassium Citrate Monohydrate
Tripotassium Citrate Monohydrate USP is a pharmaceutical-grade potassium salt of citric acid, widely used for its alkalinizing, buffering, and chelating properties. It appears as a white crystalline powder and is highly soluble in water. This compound is primarily used to correct metabolic acidosis, act as a urinary alkalinizer, and serve as an additive in pharmaceutical, food, and industrial applications. The USP grade ensures compliance with United States Pharmacopeia standards, guaranteeing high purity and consistent quality.
Tripotassium Citrate Monohydrate
Primary Uses
- Pharmaceutical Industry:
- Used as an alkalinizing agent in treatments for kidney stone prevention, urinary tract infections, and metabolic acidosis.
- Incorporated in effervescent tablets and powders to provide potassium supplementation and urine alkalization.
- Acts as a buffering agent in pharmaceutical formulations to stabilize pH.
- Food Industry:
- Serves as a food additive to regulate acidity and as an emulsifier in beverages, dairy products, and processed foods
- Used as a sequestrant and stabilizer in canned fruits and jams.
Secondary Uses
- Cosmetics and Personal Care
- Used in skin care products as a pH adjuster and buffering agent.
- Industrial Applications:
- Functions as a chelating agent in cleaning products and detergents to bind metal ions and improve efficacy.
- Agriculture:
- Occasionally used in fertilizers as a potassium source and pH modifier.
1. Basic Key Attributes
- Chemical Name (IUPAC): Tripotassium 2-hydroxypropane-1,2,3-tricarboxylate monohydrate
- Common/Trade Name: Tripotassium Citrate Monohydrate USP
- CAS Number: 6100-05-6
- HS Code: 2918.16.00
- Synonyms: Potassium citrate monohydrate, tripotassium citrate
2. Physical & Chemical Properties
- Physical State: White crystalline powder or granules
- Color & Odor: White; odorless
- Melting Point: Approx. 180 °C (decomposes)
- Solubility: Highly soluble in water; insoluble in alcohol
- pH: Alkaline aqueous solution (pH ~9.0)
3. Safety & Hazard Attributes
- GHS Classification: Not classified as hazardous under normal handling
- Toxicity: Low toxicity; considered safe when used as directed
- Exposure Limits: No specific occupational limits; standard good practices apply
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry, well-ventilated area, away from moisture and incompatible substances
- Container Type: Sealed plastic bags or drums, moisture-proof packaging preferred
- Shelf Life: 24 months under recommended storage conditions
- Handling Precautions: Avoid dust generation and exposure to moisture
5. Regulatory & Compliance Attributes
- Complies with United States Pharmacopeia (USP) standards
- Manufactured under Good Manufacturing Practices (GMP)
- Listed on major chemical inventories including TSCA and REACH
- Approved for use in food, pharmaceutical, and cosmetic applications as per regulatory requirements
6. Environmental & Health Impact
- Biodegradability: Biodegradable under aerobic conditions
- Ecotoxicity: Low toxicity to aquatic organisms
- Bioaccumulation: Not significant
Safety Handling Precautions
- PPE Required: Gloves, dust mask, and eye protection recommended during handling
- Handling Guidelines: Use adequate ventilation to minimize dust exposure
- Storage Measures: Keep containers sealed and dry
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if respiratory symptoms develop
- Skin Contact: Wash with soap and water
- Eye Contact: Rinse with plenty of water for at least 15 minutes; seek medical help if irritation persists
- Ingestion: Rinse mouth; seek medical advice if adverse effects occur
Firefighting Measures
- Fire Hazards: Non-flammable
- Extinguishing Media: Use water spray, foam, or dry chemical extinguishers
- Hazardous Combustion Products: May emit carbon oxides on decomposition
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