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Maninitol BP
Maninitol BP is a white, crystalline, sugar alcohol derived from mannose, widely used in pharmaceutical, food, and cosmetic industries. It functions as a sweetener, humectant, and excipient. Mannitol BP is non-hygroscopic and has low sweetness compared to sucrose, making it ideal for sugar-free formulations. It is commonly employed in tablet manufacturing as a filler and binder, and in medical settings as an osmotic diuretic to reduce intracranial pressure. The British Pharmacopoeia (BP) grade ensures compliance with pharmacopeial standards for purity and quality.
Maninitol BP
Primary Uses
- Pharmaceutical Industry
- Excipient in Tablets and Capsules: Used as a filler, binder, and diluent due to its compressibility and stability.
- Osmotic Diuretic Agent: Administered intravenously to reduce brain edema and treat increased intracranial pressure.
- Carrier for Medicinal Formulations: Employed in powders and sprays for respiratory therapies.
- Food Industry
- Low-Calorie Sweetener: Used in sugar-free and diabetic-friendly food products, including chewing gum, candies, and baked goods.
- Humectant: Retains moisture in food products, extending shelf life and improving texture.
- Cosmetic Industry
- Moisturizer and Humectant: Incorporated in creams, lotions, and personal care products to maintain hydration.
- Texture Enhancer: Improves spreadability and feel of topical formulations.
Secondary Uses
- Medical Diagnostics
- Used in diagnostic solutions and as an additive in intravenous fluids.
- Industrial Applications
- Occasionally used in manufacturing processes requiring non-hygroscopic sugar alcohols.
1. Basic Identification Attributes
- Chemical Name (IUPAC): (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol
- Common/Trade Name: Mannitol BP
- CAS Number: 69-65-8
- HS Code: 2905.44.00
- Synonyms: Mannitol; Mannite; D-Mannitol; Sorbitol isomer
2. Physical & Chemical Properties
- Physical State: Crystalline powder or granules
- Color & Odor: White; odorless
- Molecular Formula: C₆H₁₄O₆
- Molecular Weight: 182.17 g/mol
- Solubility: Soluble in water (about 22% at 25°C), practically insoluble in ethanol and ether
- Melting Point: 165–170 °C (decomposes)
- Density: ~1.52 g/cm³
- Taste: Mildly sweet
3. Safety & Hazard Attributes
- GHS Classification:
- Not classified as hazardous
- Toxicity:
- Non-toxic and generally recognized as safe (GRAS)
- Exposure Limits:
- No occupational exposure limits established
4. Storage & Handling Attributes
- Storage Conditions:
- Store in a cool, dry, well-ventilated place away from moisture and direct sunlight
- Container Type:
- Supplied in sealed plastic or paper bags with moisture barriers
- Shelf Life:
- Typically 2–3 years when stored properly
- Handling Precautions:
- Avoid dust generation
- Use standard hygiene practices
5. Regulatory & Compliance Attributes
- Complies with British Pharmacopoeia (BP) standards
- Approved for food and pharmaceutical applications globally
- Meets requirements for pharmaceutical excipients and food additives
6. Environmental & Health Impact
- Biodegradability: Readily biodegradable
- Ecotoxicity: Low toxicity to aquatic life
- Bioaccumulation: Not expected to bioaccumulate
- Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic
Safety Handling Precautions
- PPE Required:
- Use gloves and dust masks if handling large quantities to avoid inhalation
- Handling Guidelines:
- Handle in well-ventilated areas
- Avoid generating dust
- Storage Measures:
- Keep containers tightly closed and dry
- Store away from incompatible substances such as strong oxidizers
First Aid Measures
- Inhalation: Move to fresh air if respiratory irritation occurs
- Skin Contact: Wash with soap and water
- Eye Contact: Rinse eyes thoroughly with water; seek medical advice if irritation persists
- Ingestion: Generally safe; excessive intake may cause laxative effects; seek medical advice if adverse symptoms appear
Firefighting Measures
- Fire Hazards: Non-flammable but may burn under intense heat
- Extinguishing Media: Water spray, foam, dry chemical, or carbon dioxide extinguishers
- Special Precautions: Avoid dust cloud formation which may pose explosion hazard in confined spaces
- Hazardous Combustion Products: Carbon oxides and other toxic fumes
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