Maninitol BP

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Maninitol BP is a white, crystalline, sugar alcohol derived from mannose, widely used in pharmaceutical, food, and cosmetic industries. It functions as a sweetener, humectant, and excipient. Mannitol BP is non-hygroscopic and has low sweetness compared to sucrose, making it ideal for sugar-free formulations. It is commonly employed in tablet manufacturing as a filler and binder, and in medical settings as an osmotic diuretic to reduce intracranial pressure. The British Pharmacopoeia (BP) grade ensures compliance with pharmacopeial standards for purity and quality.

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Category: Excipients Tags: Food additive, Mannitol BP, Pharmaceutical Grade, Sugar alcohol, Sweetener

Description

Table of Contents

Maninitol BP

Primary Uses

Pharmaceutical Industry

Excipient in Tablets and Capsules: Used as a filler, binder, and diluent due to its compressibility and stability.
Osmotic Diuretic Agent: Administered intravenously to reduce brain edema and treat increased intracranial pressure.
Carrier for Medicinal Formulations: Employed in powders and sprays for respiratory therapies.

Food Industry

Low-Calorie Sweetener: Used in sugar-free and diabetic-friendly food products, including chewing gum, candies, and baked goods.
Humectant: Retains moisture in food products, extending shelf life and improving texture.

Cosmetic Industry

Moisturizer and Humectant: Incorporated in creams, lotions, and personal care products to maintain hydration.
Texture Enhancer: Improves spreadability and feel of topical formulations.

Secondary Uses

Medical Diagnostics

Used in diagnostic solutions and as an additive in intravenous fluids.

Industrial Applications

Occasionally used in manufacturing processes requiring non-hygroscopic sugar alcohols.

KEY PRODUCT FEATURES

1. Basic Identification Attributes

Chemical Name (IUPAC): (2R,3R,4R,5R)-Hexane-1,2,3,4,5,6-hexol
Common/Trade Name: Mannitol BP
CAS Number: 69-65-8
HS Code: 2905.44.00
Synonyms: Mannitol; Mannite; D-Mannitol; Sorbitol isomer

2. Physical & Chemical Properties

Physical State: Crystalline powder or granules
Color & Odor: White; odorless
Molecular Formula: C₆H₁₄O₆
Molecular Weight: 182.17 g/mol
Solubility: Soluble in water (about 22% at 25°C), practically insoluble in ethanol and ether
Melting Point: 165–170 °C (decomposes)
Density: ~1.52 g/cm³
Taste: Mildly sweet

3. Safety & Hazard Attributes

GHS Classification:
- Not classified as hazardous
Toxicity:
- Non-toxic and generally recognized as safe (GRAS)
Exposure Limits:
- No occupational exposure limits established

4. Storage & Handling Attributes

Storage Conditions:
- Store in a cool, dry, well-ventilated place away from moisture and direct sunlight
Container Type:
- Supplied in sealed plastic or paper bags with moisture barriers
Shelf Life:
- Typically 2–3 years when stored properly
Handling Precautions:
- Avoid dust generation
- Use standard hygiene practices

5. Regulatory & Compliance Attributes

Complies with British Pharmacopoeia (BP) standards
Approved for food and pharmaceutical applications globally
Meets requirements for pharmaceutical excipients and food additives

6. Environmental & Health Impact

Biodegradability: Readily biodegradable
Ecotoxicity: Low toxicity to aquatic life
Bioaccumulation: Not expected to bioaccumulate
Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE Required:
- Use gloves and dust masks if handling large quantities to avoid inhalation
Handling Guidelines:
- Handle in well-ventilated areas
- Avoid generating dust
Storage Measures:
- Keep containers tightly closed and dry
- Store away from incompatible substances such as strong oxidizers

First Aid Measures

Inhalation: Move to fresh air if respiratory irritation occurs
Skin Contact: Wash with soap and water
Eye Contact: Rinse eyes thoroughly with water; seek medical advice if irritation persists
Ingestion: Generally safe; excessive intake may cause laxative effects; seek medical advice if adverse symptoms appear

Firefighting Measures

Fire Hazards: Non-flammable but may burn under intense heat
Extinguishing Media: Water spray, foam, dry chemical, or carbon dioxide extinguishers
Special Precautions: Avoid dust cloud formation which may pose explosion hazard in confined spaces
Hazardous Combustion Products: Carbon oxides and other toxic fumes