Zinc Pyrithione

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Zinc Pyrithione is a high-purity antimicrobial and antifungal compound derived from the coordination of zinc with pyrithione (1-hydroxy-2-pyridinethione). It is widely used as an active ingredient in personal care formulations, industrial coatings, and materials preservation due to its broad-spectrum biocidal efficacy against bacteria, fungi, and algae. Its excellent thermal stability and compatibility with various systems make it ideal for diverse industrial and cosmetic applications.

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Categories: Active Pharmaceutical Ingredients (APIs), Preservatives Tags: Anti-Hair Loss, Antibacterial, Antimicrobial Compound, Cosmetic preservative, Dandruff Treatment', Pharmaceutical Additive, Zinc Pyrithione

Description

Table of Contents

Zinc Pyrithione

Primary Uses

Personal Care & Cosmetics

Anti-Dandruff Agent: Widely used in shampoos and scalp treatments to control dandruff and seborrheic dermatitis.
Antifungal in Skin Products: Used in creams and lotions to treat fungal skin conditions like tinea and seborrheic dermatitis.

Paints & Coatings Industry

Dry Film Preservative: Protects painted surfaces from fungal and algal growth, especially in humid conditions.
Marine Coatings: Used in anti-fouling marine paints to prevent biofilm formation on ship hulls and underwater structures.

Plastics & Polymers

Antimicrobial Additive: Integrated into plastic products, sealants, and silicone to prevent microbial colonization.

Textiles

Antibacterial Treatment: Used in technical and medical textiles for microbial control and odor resistance.

Secondary Uses

Construction Materials

Biocide in Sealants and Adhesives: Added to construction sealants to prevent mold and mildew.

Industrial Water Systems

Microbial Control Agent: Occasionally used in industrial water circuits to prevent microbial growth (under regulated conditions).

Leather Treatment

Preservative: Applied during leather processing to inhibit microbial degradation and mold formation.

Agriculture (Restricted/Regulated)

Fungicide (Specialty Applications): Under strict regulatory control, used in select applications to prevent fungal growth on surfaces or equipment.

KEY PRODUCT FEATURES

Basic Identification Attributes

Chemical Name (IUPAC): Bis(1-hydroxy-2(1H)-pyridinethionato-O,S)zinc
Common/Trade Name: Zinc Pyrithione
CAS Number: 13463-41-7
HS Code: 2930.90.99
Synonyms: ZPT, Zinc Omadine, Zinci pyrithionis

Physical & Chemical Properties

Physical State: Crystalline powder
Color & Odor: White to pale yellow; faint odor
Melting Point: ~240 °C (decomposes)
Solubility: Poorly soluble in water; soluble in ethanol and surfactant systems
pH (1% Suspension): ~6.5–8.0
Density: ~1.8 g/cm³

Safety & Hazard Attributes

GHS Classification:
- Harmful if swallowed
- Causes serious eye irritation
- Very toxic to aquatic life with long-lasting effects
Toxicity: Moderately toxic; not for internal or long-term unregulated exposure
Exposure Limits: Avoid inhalation of powder; handle with PPE

Storage & Handling Attributes

Storage Conditions: Store in a cool, dry place, in tightly sealed containers away from direct sunlight and moisture
Container Type: Fiber drums or HDPE containers with liners
Shelf Life: 2 years under proper storage conditions
Handling Precautions: Avoid dust generation and contact with eyes or skin

Regulatory & Compliance Attributes

Approved by FDA, EU, and other regulatory bodies for limited concentrations in personal care products
Complies with REACH and TSCA for industrial use
Subject to maximum concentration limits in cosmetics (typically 0.3% in rinse-off products)
Not for use in food or pharmaceutical products
Manufactured under ISO 9001 and ISO 22716 (GMP for cosmetics, when applicable)
Must meet biocidal product regulations (BPR) in the EU and FIFRA in the U.S.

Environmental & Health Impact

Biodegradability: Slowly biodegradable under environmental conditions
Ecotoxicity: Highly toxic to aquatic organisms; must not be released into waterways
Bioaccumulation: Low to moderate potential; environmental monitoring recommended

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE Required: Gloves, goggles, dust mask or respirator
Handling Guidelines: Use local exhaust ventilation; avoid formation of airborne dust
Storage Measures: Keep containers tightly sealed; label clearly

First Aid Measures

Inhalation: Move to fresh air immediately; seek medical attention if breathing difficulties occur
Skin Contact: Wash thoroughly with soap and water
Eye Contact: Rinse cautiously with water for 15 minutes; consult a physician
Ingestion: Rinse mouth with water; do not induce vomiting; seek medical help

Firefighting Measures

Fire Hazards: Non-flammable; may release toxic fumes (sulfur oxides, zinc oxides) if heated excessively
Extinguishing Media: Water spray, dry powder, CO₂
Hazardous Combustion Products: Sulfur dioxide, zinc oxide fumes