Preservatives(food)
Flavor Enhancers
Acidulants
Sweeteners
Antioxidants
Colorants(food)
Nutraceutical Ingredients (food)
Nutrient Supplements
Emulsifiers
Collectors
Dust Suppressants
Explosives and Blasting Agents
Flocculants and Coagulants
Frothers
Leaching Agents
pH Modifiers
Precious Metal Extraction Agents
Antioxidants(plastic)
Colorants (Pigments, Dyes)
Fillers and Reinforcements
Flame Retardants
Monomers
Plasticizers
Polymerization Initiators
Stabilizers (UV, Heat)
Antifoaming Agents
Chelating Agents
Coagulants and Flocculants
Corrosion Inhibitors
Disinfectants and Biocides
Oxidizing Agents
pH Adjusters
Scale Inhibitors( water)
Antioxidants(cosmetic)
Emollients
Fragrances and Essential Oils
Humectants
Preservatives
Surfactants(cosmetic)
Thickeners
UV Filters
Fertilizers
Soil Conditioners
Plant Growth Regulators
Animal Feed Additives
Biostimulants
Pesticides (Herbicides, Insecticides, Fungicides)
Active Pharmaceutical Ingredients (APIs)
Excipients
Solvents(pharmaceutical)
Antibiotics
Antiseptics and Disinfectants
Vaccine Adjuvants
Nutraceutical Ingredients (pharmaceutical)
Analgesics & Antipyretics
Analytical Reagents
Solvents(lab)
Chromatography Chemicals
Spectroscopy Reagents
microbiology-and-cell-culture-reagents
Molecular Biology Reagents
Biochemical Reagents
Inorganic and Organic Standards
Laboratory Safety Chemicals
Specialty Laboratory Chemicals(Special Laboratory Equipment)
Demulsifiers
Hydraulic Fracturing Fluids
Scale Inhibitors(oil)
Surfactants(oil)
Drilling Fluids
Dyes and Pigments
Bleaching Agents
Softening Agents
Finishing Agents
Antistatic Agents
Admixtures
Waterproofing Agents
Sealants and Adhesives
Curing Compounds
Concrete Repair Chemicals
Anti-Corrosion Coatings
Surfactants(cleaning)
Builders
Enzymes
Solvents (Cleaning)
Fragrances
Electronic Chemicals
Catalysts
Lubricants
Photographic Chemicals
Refrigerants
Automotive chemicals
Pyrotechnic Chemicals
Biodegradable Surfactants
Bio-based Solvents
Renewable Polymers
Carbon Capture Chemicals
Wastewater Treatment Chemicals
Pigments
Solvents(paint)
Specialty Coatings
Binders/Resins
Additives
Driers
Anti-Corrosion Agents
Functional Coatings
Application-Specific Coatings
Leavening Agents
Dough Conditioners
Flour Treatments
Fat Replacers
Decoratives
Preservatives(baking)
Plasticizers & Softeners
Reinforcing Agents
Adhesion Promoters
Vulcanizing Agents
Antidegradants
Blowing Agents
Fillers & Extenders
Accelerators & Retarders
Pyrimethamine HCL Micronised
Pyrimethamine HCL Micronised is a finely ground form of pyrimethamine hydrochloride, an antimalarial and antiparasitic drug. The micronised form enhances bioavailability by improving dissolution rate and absorption. It acts by inhibiting dihydrofolate reductase, interfering with folic acid metabolism in protozoa and some bacteria, thus effectively treating malaria and toxoplasmosis. This pharmaceutical-grade compound is used primarily in combination therapies for parasitic infections.
Pyrimethamine HCL Micronised
Primary Uses
- Pharmaceutical Industry
- Used as an active pharmaceutical ingredient (API) in antimalarial medications, often combined with sulfadoxine (e.g., Fansidar) for treating Plasmodium falciparum malaria.
- Employed in the treatment of toxoplasmosis, especially in immunocompromised patients.
- Utilized in combination therapy for other parasitic infections sensitive to folate pathway inhibition.
Secondary Uses
- Veterinary Medicine
- Used in veterinary antiparasitic formulations for protozoal infections in animals.
- Research & Development
- Utilized in pharmaceutical research for new antimalarial drug development and formulation studies.
- Used as a reference standard in analytical and pharmacokinetic studies.
1. Basic Identification Attributes
- Chemical Name (IUPAC): 5-(4-chlorophenyl)-6-ethylpyrimidine-2,4-diamine hydrochloride
- Common/Trade Name: Pyrimethamine HCL Micronised
- CAS Number: 145-62-8
- HS Code: 2933.99.90
- Synonyms: Daraprim (brand name), Pyrimethamine hydrochloride
2. Physical & Chemical Properties
- Physical State: Fine white to off-white powder
- Solubility: Slightly soluble in water; soluble in dilute acids
- Particle Size: Micronised for enhanced dissolution
- Molecular Weight: 248.7 g/mol (free base), hydrochloride salt varies slightly
- Odor & Color: Odorless; white powder
3. Safety & Hazard Attributes
- GHS Classification: Harmful if swallowed; may cause skin and eye irritation
- Toxicity: Moderate toxicity; handle with care to avoid exposure
- Exposure Limits: Follow pharmaceutical safety guidelines
4. Storage & Handling Attributes
- Storage Conditions: Store in a tightly closed container in a cool, dry, and well-ventilated area protected from light
- Container Type: Sealed plastic or glass containers, foil-lined bags
- Shelf Life: Typically 2–3 years if stored properly
- Handling Precautions: Use gloves, mask, and eye protection; avoid dust inhalation
5. Regulatory & Compliance Attributes
- Complies with USP/NF monograph for pyrimethamine hydrochloride
- Manufactured under GMP conditions for pharmaceutical use
6. Environmental & Health Impact
- Biodegradability: Not readily biodegradable
- Ecotoxicity: Toxic to aquatic organisms at high concentrations
- Bioaccumulation: Not significant
Safety Handling Precautions
- PPE Required: Gloves, dust mask, goggles recommended
- Handling Guidelines: Use in well-ventilated areas; avoid skin and eye contact
- Storage Measures: Keep containers tightly closed and stored in a dry, cool environment away from light
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if symptoms develop
- Skin Contact: Wash with soap and water; seek medical advice if irritation persists
- Eye Contact: Rinse with plenty of water for 15 minutes; seek medical attention if irritation continues
- Ingestion: Do not induce vomiting; seek immediate medical attention
Firefighting Measures
- Fire Hazards: Not highly flammable but may decompose on heating releasing toxic fumes
- Extinguishing Media: Use water spray, foam, dry chemical, or CO₂
- Special Precautions: Wear protective clothing and self-contained breathing apparatus
- Hazardous Combustion Products: Carbon oxides, nitrogen oxides, hydrogen chloride
Related products
Dicyclomine Hydrochloride
Dicyclomine Hydrochloride is an anticholinergic and antispasmodic agent used primarily to relieve smooth muscle spasms in the gastrointestinal tract. It works by blocking muscarinic receptors, thereby reducing muscle contractions and spasms, which helps alleviate symptoms of irritable bowel syndrome (IBS) and other functional bowel disorders. It is commonly available in oral tablets, capsules, and injectable formulations.
Gentamycin Sulphate
Gentamycin Sulphate is an aminoglycoside antibiotic derived from Micromonospora purpurea and Micromonospora griseorubida. It appears as a white or off-white crystalline powder, highly soluble in water, with a characteristic aminoglycoside odor. Gentamycin Sulphate is widely used in human and veterinary medicine for its broad-spectrum bactericidal activity against aerobic Gram-negative and some Gram-positive bacteria. It works by inhibiting bacterial protein synthesis through binding to the 30S ribosomal subunit, leading to bacterial cell death. Due to its effectiveness against severe infections and multi-drug resistant strains, it is an essential antibiotic in clinical settings.
Guaiphenesin BP
Guaiphenesin BP is a white crystalline powder or granules with a faint characteristic odor, classified as an expectorant used primarily in pharmaceutical formulations to relieve chest congestion. It works by loosening and thinning mucus in the airways, making it easier to cough up and clear from the respiratory tract. It is widely utilized in cough syrups, tablets, and cold remedies. Recognized for its mucolytic and muscle-relaxant properties, Guaiphenesin is included in both prescription and over-the-counter medications worldwide.
Hydrocortisone Acetate
Hydrocortisone Acetate is a synthetic corticosteroid ester derived from hydrocortisone (cortisol). It is a white to off-white crystalline powder, practically insoluble in water but soluble in alcohol and acetone. This compound exhibits potent anti-inflammatory, immunosuppressive, and anti-allergic properties, making it widely used in pharmaceutical and dermatological formulations. Hydrocortisone Acetate acts by modulating gene expression to reduce the production of inflammatory mediators, thereby alleviating symptoms in various inflammatory and autoimmune conditions.
Ivermectin BP Vet
Ivermectin BP Vet is a potent, broad-spectrum antiparasitic agent widely used in veterinary medicine. It belongs to the avermectin family and works by disrupting nerve and muscle function in parasites, leading to paralysis and death. Ivermectin is highly effective against a range of internal and external parasites, including gastrointestinal worms, lungworms, mites, lice, and certain ticks. Available in oral, injectable, and topical forms, it is trusted for use in livestock, poultry, and companion animals. Its reliable efficacy, wide safety margin, and ease of administration make it an essential treatment in animal health and parasite control programs.
Metronidazole BP
Metronidazole BP is a benzoate ester derivative of metronidazole, used primarily as an antiprotozoal and antibacterial agent. It is a prodrug that hydrolyzes in the body to release metronidazole, making it more palatable for pediatric and geriatric oral suspensions. It complies with the British Pharmacopoeia (BP) standards for purity and efficacy.
Norfloxacin
Norfloxacin is a synthetic broad-spectrum fluoroquinolone antibiotic used primarily to treat bacterial infections. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication, transcription, repair, and recombination, leading to bacterial cell death. Norfloxacin is effective against various Gram-negative and some Gram-positive bacteria and is commonly used in urinary tract infections, prostatitis, and gastroenteritis.
Piperazine Citrate BP
Piperazine Citrate BP is a pharmaceutical-grade anthelmintic compound used primarily for the treatment of intestinal worm infections, especially ascariasis (roundworms) and enterobiasis (pinworms). It works by paralyzing the worms, allowing them to be expelled naturally from the body through bowel movements. Piperazine Citrate is included in the British Pharmacopoeia (BP) and is known for its safety, efficacy, and wide use in both human and veterinary medicine.
