Alpha Arbutin

Name: Alpha Arbutin - Amaris Chemicals Solutions
SKU: ACS92955CHEM0
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Alpha arbutin is a synthetic compound derived from the natural substance called hydroquinone. It is a skin-brightening agent and a type of skin lightening ingredient commonly used in cosmetic and skincare products. Alpha arbutin works by inhibiting the activity of the enzyme tyrosinase, which is involved in the production of melanin, the pigment responsible for skin color. By reducing melanin production, alpha arbutin helps to fade and prevent the formation of dark spots, hyperpigmentation, and uneven skin tone. It is considered a safer alternative to hydroquinone, as it exhibits similar skin-lightening effects with lower risks of potential side effects.

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SKU: ACS92955CHEM0 Categories: Antioxidants (cosmetics), Analytical Reagents, Excipients, UV Filters Tags: alpha arbutin, brightening, cosmetic, skin lightening, sun damage

Description

Alpha arbutin Uses

Hyperpigmentation treatment:

Alpha arbutin is often used to treat various forms of hyperpigmentation, including dark spots, age spots, melasma, and post-inflammatory hyperpigmentation. It helps to inhibit melanin production and fade the appearance of uneven skin tone.

Skin lightening:

Alpha arbutin is used as a skin lightening agent to achieve a more uniform complexion and reduce the visibility of skin discoloration. It can be included in products such as serums, creams, lotions, and masks.

Brightening and radiance:

Alpha arbutin is known to enhance the overall brightness and radiance of the skin. It helps to promote a more youthful and glowing complexion by reducing the appearance of dullness and improving the skin’s clarity.

Anti-aging benefits:

In addition to its skin-lightening effects, alpha arbutin also possesses antioxidant properties, which can help protect the skin from free radicals and oxidative stress. This can contribute to the prevention of premature aging signs, such as fine lines, wrinkles, and age spots.

Sun damage protection:

Alpha arbutin is sometimes incorporated into sunscreens or used in combination with sunscreen products. It can help minimize the development of hyperpigmentation caused by UV exposure and provide additional protection against sun-induced skin damage.

Additional information

APPEARANCE	Crystalline
CONCENTRATION	99.9%
AVAILABLE GRADES	COSMETIC GRADE , LABOROTARY GRADE , PHARMACEUTICAL GRADE

KEY ATTRIBUTES

1. Basic Identification Attributes

Chemical Name: 4-Hydroxyphenyl α-D-glucopyranoside (IUPAC)
CAS Number: 84380-01-8
HS Code: 2938.90.90 (Other glycosides)
Molecular Formula: C₁₂H₁₆O₇
Synonyms: α-Arbutin, p-Hydroxyphenyl α-glucoside, Arbutoside

2. Physical & Chemical Properties

Physical State: White crystalline powder
Color & Odor: White; odorless
Melting Point: 195-198°C (with decomposition)
Optical Rotation: +174° to +178° (c=1, in water)
Solubility:
- Water: 50 g/100mL (20°C)
- Ethanol: 1 g/100mL
- Insoluble in ether, chloroform
pH (1% solution): 5.0-7.0
Stability:
- Stable at pH 3-8
- Light-sensitive (darkens under UV)
Purity: ≥99% (HPLC)

3. Safety & Hazard Attributes

Hazard Class: Non-hazardous (cosmetic-grade)
NFPA Ratings: Health-1, Flammability-0, Reactivity-0
Exposure Limits: No established limits
Reactivity:
- Avoid strong oxidizers
- May degrade in alkaline conditions (pH>8)

4. Storage & Handling Attributes

Storage Conditions:
- 2-8°C (long-term)
- Room temp (short-term, with desiccant)
- Protect from light (amber containers)
Shelf Life: 2 years (proper storage)
Special Handling:
- Avoid dust formation
- PPE: Gloves, dust mask

5. Regulatory & Compliance Attributes

Regulatory Status:
- EU: Approved in cosmetics (up to 7% in leave-on)
- China: Approved whitening agent
- FDA: Not banned (but not specifically approved)
Certifications:
- ISO 22716 (Cosmetic GMP)
- Halal/Kosher available

6. Environmental & Health Impact

Ecotoxicity:
- LC50 (fish): >100 mg/L
- Readily biodegradable
Carcinogenicity:
- Not classified (IARC/NTP)
Skin Penetration:
- 5-2% epidermal absorption

SAFETY PRECAUTIONS

General Handling:

Use in well-ventilated areas(avoid inhaling dust)
Avoid direct skin/eye contact(may cause mild irritation)
Keep away from strong oxidizers, acids, and bases(potential reactions)
Use non-sparking toolsif handling large quantities

Personal Protective Equipment (PPE):

Gloves:Nitrile or latex gloves
Eye Protection:Safety goggles or face shield
Respiratory Protection:NIOSH-approved N95 mask (if powder dust is present)
Clothing:Lab coat or protective apron

Storage:

Store in tightly sealed, light-resistant containers
Keep in a cool, dry place(20-25°C/68-77°F)
Protect from moisture and direct sunlight
Separate from incompatible chemicals (strong oxidizers)

Spill Management:

Small spills:Wipe with damp cloth (avoid dust generation)
Large spills:Use inert absorbent material (vermiculite, sand)
Dispose as chemical wasteper local regulations

Skin Contact:

Symptoms:Mild irritation, redness
Action:
- Remove contaminated clothing
- Wash thoroughly with soap and water(15 mins)
- Apply moisturizer if irritation persists
- Seek medical attention if rash develops

Eye Contact:

Symptoms:Redness, discomfort
Action:
- Immediately flush with lukewarm water for 15+ mins(hold eyelids open)
- Remove contact lenses if present
- Seek medical attentionif irritation continues

Inhalation:

Symptoms:Coughing, throat irritation (unlikely at normal handling)
Action:
- Move to fresh air immediately
- If breathing difficulties occur, seek medical help

Ingestion:

Symptoms:Low toxicity, but may cause stomach discomfort
Action:
- Rinse mouth with water
- Drink 1-2 glasses of water
- Do NOT induce vomiting
- Seek medical advice if large amounts ingested

Fire Hazards: