Ellagic Acid

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Ellagic Acid is a naturally occurring polyphenolic compound found in numerous fruits, nuts, and vegetables such as pomegranates, strawberries, raspberries, walnuts, and cranberries. It is a potent antioxidant known for its ability to scavenge free radicals and chelate metal ions. Due to its significant anti-inflammatory, anti-carcinogenic, and anti-viral properties, Ellagic Acid has gained extensive interest in pharmaceutical, nutraceutical, cosmetic, and food industries. It appears as a yellow to light brown crystalline powder, insoluble in water but soluble in organic solvents like ethanol and DMSO.

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Categories: Antioxidants, Nutraceutical Ingredients (pharmaceutical) Tags: Anti-Aging Active, Capsule/Tablet Ingredient, Ellagic Acid, Hyperpigmentation Treatment, Pomegranate Extract, UV Damage Protection

Description

Table of Contents

Ellagic Acid

Primary Uses

Pharmaceuticals & Nutraceuticals

Utilized as an active ingredient for its antioxidant and anti-inflammatory effects.
Employed in formulations aimed at cancer prevention and as adjunct therapy due to its anti-proliferative properties.
Investigated for potential antiviral applications including HIV and herpes simplex viruses.
Used in dietary supplements for general health and immune support.

Cosmetics & Personal Care

Incorporated in anti-aging skin care products for its ability to protect skin from oxidative damage and UV-induced aging.
Used in formulations targeting hyperpigmentation and skin brightening due to its melanin synthesis inhibition.
Acts as an anti-inflammatory agent soothing irritated or sensitive skin.

Food Industry

Applied as a natural antioxidant additive in food preservation to extend shelf life and prevent lipid peroxidation.
Used as a functional ingredient in health foods, beverages, and supplements.

Research & Analytical Uses

Used in biochemical research to study antioxidant mechanisms and as a standard compound in polyphenol analysis.

Secondary Uses

Agriculture

Explored as a natural plant growth regulator and for potential pest resistance due to its antimicrobial properties.

Biomedical Research

Investigated in tissue engineering and regenerative medicine for its cell-protective effects.

KEY PRODUCT FEATURES

1. Basic Identification Attributes

Chemical Name (IUPAC): 2,3,7,8-Tetrahydroxy-[1]benzopyrano[5,4,3-cde][1]benzopyran-5,10-dione
Common/Trade Name: Ellagic Acid
CAS Number: 476-66-4
HS Code: 2934.99.99
Molecular Formula: C₁₄H₆O₈
Synonyms:
- 4,4',5,5',6,6'-Hexahydroxydiphenic acid dilactone
- 2,3,7,8-Tetrahydroxychromeno[5,4,3-cde]chromene-5,10-dione

2. Physical & Chemical Properties

Physical State: Crystalline powder
Color & Odor: Yellow to light brown; odorless
Melting Point: Approximately 300°C (decomposes)
Solubility: Insoluble in water; soluble in ethanol, methanol, DMSO, and alkaline solutions
Stability: Stable under normal conditions; sensitive to strong acids and bases

3. Safety & Hazard Attributes

Hazard Class (GHS): Not classified as hazardous
Toxicity: Low toxicity; generally safe in topical and oral use at recommended doses
Exposure Limits: Not established

4. Storage & Handling Attributes

Storage Conditions: Store in cool, dry, dark place in tightly sealed containers
Container Type: Glass or plastic bottles with airtight caps
Shelf Life: 2–3 years if stored properly
Handling Precautions: Avoid dust inhalation and prolonged skin contact

5. Regulatory & Compliance Attributes

Approved as a dietary supplement ingredient in many regions
Compliant with food safety and cosmetic regulations globally

6. Environmental & Health Impact

Biodegradability: Biodegradable under environmental conditions
Ecotoxicity: Low
Bioaccumulation: Not expected
Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE Required:

Dust mask or respirator (for powder handling)
Safety goggles
Gloves (nitrile or latex)
Protective clothing or lab coat

Handling Guidelines:

Handle in well-ventilated areas
Avoid dust generation and inhalation
Avoid prolonged skin contact
Use closed systems or local exhaust ventilation when available

Storage Measures:

Keep container tightly closed
Store away from strong oxidizers and bases
Protect from light and moisture

Hygiene Practices:

Wash hands after handling
Do not eat, drink, or smoke in handling areas
Clean spills promptly to avoid dust spread

First Aid Measures

Inhalation: Move to fresh air; seek medical attention if irritation persists
Skin Contact: Wash thoroughly with soap and water; seek medical attention if irritation develops
Eye Contact: Rinse with plenty of water for 15 minutes; seek medical advice if irritation persists
Ingestion: Rinse mouth; not expected to be toxic, but seek medical attention if large amounts ingested

Firefighting Measures

Fire Hazards: Non-flammable
Extinguishing Media: Water spray, foam, dry chemical, or carbon dioxide
Special Precautions: Use standard protective equipment
Decomposition Products: May emit carbon monoxide, carbon dioxide, and other organic vapors upon decomposition