Prednisolone Base

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Prednisolone Base is a synthetic glucocorticoid steroid widely used for its potent anti-inflammatory and immunosuppressive properties. It is the active form of prednisolone, commonly administered in various pharmaceutical formulations including tablets, injectables, and topical creams. This compound helps manage conditions involving inflammation, allergic reactions, and immune system disorders by modulating the body’s response to these processes.

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Category: Active Pharmaceutical Ingredients (APIs) Tags: Anti-inflammatory agent, Glucocorticoid Steroid, Pharmaceutical ingredient, Prednisolone Base

Description

Table of Contents

Prednisolone Base

Primary Uses

Pharmaceuticals

Used in the treatment of inflammatory and autoimmune diseases such as arthritis, lupus, and asthma.
Administered to suppress immune responses in conditions like organ transplant rejection.
Employed in topical formulations to treat skin conditions such as eczema, psoriasis, and dermatitis.
Used in ophthalmic preparations for inflammatory eye conditions.

Veterinary Medicine
Used to manage inflammatory and autoimmune conditions in animals.

Secondary Uses

Research and Development

Utilized in clinical and pharmacological research studies investigating steroid effects and inflammatory pathways.

Endocrinology

Used in diagnostic testing of adrenal gland function.

KEY PRODUCT FEATURES

1. Basic Identification Attributes

Chemical Name (IUPAC): 11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione

Common/Trade Name: Prednisolone Base
CAS Number: 50-24-8
HS Code: 2937.29
Synonyms: 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione; Delta-cortef

2. Physical & Chemical Properties

Physical State: Crystalline powder
Color & Odor: White to off-white; odorless
Solubility: Slightly soluble in water; soluble in alcohol, acetone, and chloroform
Melting Point: Approximately 240–245°C
Stability: Stable under recommended storage conditions

3. Safety & Hazard Attributes

GHS Classification: May cause skin and eye irritation; harmful if swallowed in large quantities
Toxicity: Moderate; requires careful dosing and medical supervision
Exposure Limits: Follow occupational safety guidelines

4. Storage & Handling Attributes

Storage Conditions: Store in a cool, dry place protected from light
Container Type: Sealed amber bottles or vials
Shelf Life: Typically 2–3 years
Handling Precautions: Use gloves and protective clothing; avoid inhalation and skin contact

5. Regulatory & Compliance Attributes

Complies with pharmacopeial standards such as USP, BP, and EP
Approved for use in prescription medications worldwide

6. Environmental & Health Impact

Biodegradability: Organic compound; biodegradable under environmental conditions

Ecotoxicity: Low when properly disposed

Bioaccumulation: Not significant

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE Required: Gloves, goggles, and lab coat recommended
Handling Guidelines: Avoid inhalation, ingestion, and skin contact; work in well-ventilated areas
Storage Measures: Keep containers tightly closed and protected from light

First Aid Measures

Inhalation: Move to fresh air; seek medical attention if breathing difficulties occur
Skin Contact: Wash with soap and water; seek medical advice if irritation develops
Eye Contact: Rinse eyes with water for at least 15 minutes; seek medical attention if irritation persists

Ingestion: Rinse mouth; seek immediate medical attention