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Prednisolone Base
Prednisolone Base is a synthetic glucocorticoid steroid widely used for its potent anti-inflammatory and immunosuppressive properties. It is the active form of prednisolone, commonly administered in various pharmaceutical formulations including tablets, injectables, and topical creams. This compound helps manage conditions involving inflammation, allergic reactions, and immune system disorders by modulating the body’s response to these processes.
Prednisolone Base
Primary Uses
- Pharmaceuticals
- Used in the treatment of inflammatory and autoimmune diseases such as arthritis, lupus, and asthma.
- Administered to suppress immune responses in conditions like organ transplant rejection.
- Employed in topical formulations to treat skin conditions such as eczema, psoriasis, and dermatitis.
- Used in ophthalmic preparations for inflammatory eye conditions.
- Veterinary Medicine
Used to manage inflammatory and autoimmune conditions in animals.
Secondary Uses
- Research and Development
- Utilized in clinical and pharmacological research studies investigating steroid effects and inflammatory pathways.
- Endocrinology
- Used in diagnostic testing of adrenal gland function.
1. Basic Identification Attributes
Chemical Name (IUPAC): 11β,17,21-Trihydroxypregna-1,4-diene-3,20-dione
- Common/Trade Name: Prednisolone Base
- CAS Number: 50-24-8
- HS Code: 2937.29
- Synonyms: 11β,17α,21-Trihydroxypregna-1,4-diene-3,20-dione; Delta-cortef
2. Physical & Chemical Properties
- Physical State: Crystalline powder
- Color & Odor: White to off-white; odorless
- Solubility: Slightly soluble in water; soluble in alcohol, acetone, and chloroform
- Melting Point: Approximately 240–245°C
- Stability: Stable under recommended storage conditions
3. Safety & Hazard Attributes
- GHS Classification: May cause skin and eye irritation; harmful if swallowed in large quantities
- Toxicity: Moderate; requires careful dosing and medical supervision
- Exposure Limits: Follow occupational safety guidelines
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place protected from light
- Container Type: Sealed amber bottles or vials
- Shelf Life: Typically 2–3 years
- Handling Precautions: Use gloves and protective clothing; avoid inhalation and skin contact
5. Regulatory & Compliance Attributes
- Complies with pharmacopeial standards such as USP, BP, and EP
- Approved for use in prescription medications worldwide
6. Environmental & Health Impact
Biodegradability: Organic compound; biodegradable under environmental conditions
Ecotoxicity: Low when properly disposed
Bioaccumulation: Not significant
Safety Handling Precautions
- PPE Required: Gloves, goggles, and lab coat recommended
- Handling Guidelines: Avoid inhalation, ingestion, and skin contact; work in well-ventilated areas
- Storage Measures: Keep containers tightly closed and protected from light
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if breathing difficulties occur
- Skin Contact: Wash with soap and water; seek medical advice if irritation develops
- Eye Contact: Rinse eyes with water for at least 15 minutes; seek medical attention if irritation persists
Ingestion: Rinse mouth; seek immediate medical attention
Firefighting Measures
- Fire Hazards: Combustible under fire conditions
- Extinguishing Media: Use water spray, foam, dry chemical, or CO₂
- Special Precautions: Wear self-contained breathing apparatus
- Hazardous Combustion Products: Carbon oxides and other toxic fumes
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