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PHARMACEUTICAL GRADE USP GRADE

Prednisolone Sodium Phosphate

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Prednisolone Sodium Phosphate is a water-soluble ester of prednisolone, a synthetic glucocorticoid steroid with potent anti-inflammatory and immunosuppressive effects. Its enhanced solubility makes it suitable for injectable formulations and rapid systemic action. It is commonly used to treat various inflammatory, allergic, and autoimmune conditions, offering effective modulation of immune responses and inflammation.

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Description

Primary Uses
Pharmaceuticals
Used in intravenous and intramuscular injections for rapid treatment of acute inflammatory and allergic conditions such as asthma exacerbations, severe allergic reactions, and shock.

Administered in oral and parenteral formulations for autoimmune diseases like rheumatoid arthritis and lupus.

Utilized in ophthalmic preparations for inflammatory eye diseases.

Veterinary Medicine
Used in veterinary injections to manage inflammation and immune-mediated diseases in animals.

 

Secondary Uses
Clinical Research
Used in pharmacokinetic and pharmacodynamic studies involving glucocorticoids.

Diagnostic Applications
Employed in testing adrenal gland function due to its glucocorticoid activity.

PRODUCT KEY FEATURES

Basic Identification Attributes
Chemical Name (IUPAC): Disodium (11β)-11,17,21-trihydroxypregna-1,4-diene-3,20-dione 21-phosphate

Common/Trade Name: Prednisolone Sodium Phosphate

CAS Number: 125-02-0

HS Code: 2937.29

Synonyms: Prednisolone phosphate disodium salt; Sodium prednisolone phosphate

Physical & Chemical Properties
Physical State: White to off-white crystalline powder

Color & Odor: White to off-white; odorless

Solubility: Highly soluble in water

Melting Point: Approximately 260–265°C (decomposes)

Stability: Stable under recommended storage conditions

Safety & Hazard Attributes
GHS Classification: May cause skin and eye irritation; handle with care

Toxicity: Moderate; requires medical supervision for use

Exposure Limits: Follow occupational safety guidelines

Storage & Handling Attributes
Storage Conditions: Store in a cool, dry place, protected from moisture and light

Container Type: Sealed glass or plastic containers

Shelf Life: Typically 2–3 years

Handling Precautions: Use gloves and protective clothing; avoid inhalation and contact

 

Regulatory & Compliance Attributes
Complies with pharmacopeial standards such as USP, BP, and EP

Approved for use in injectable and oral pharmaceutical formulations

 

Environmental & Health Impact
Biodegradability: Organic compound; biodegradable under environmental conditions

Ecotoxicity: Low when disposed properly

Bioaccumulation: Not significant

SAFETY HANDLING PRECAUTIIONS

Safety Handling Precautions
PPE Required: Gloves, goggles, and lab coat recommended

Handling Guidelines: Avoid inhalation, ingestion, and skin contact; use in well-ventilated areas

Storage Measures: Keep containers tightly closed and protected from moisture

 

First Aid Measures
Inhalation: Move to fresh air; seek medical attention if breathing difficulties occur

Skin Contact: Wash with soap and water; seek medical advice if irritation develops

Eye Contact: Rinse eyes with water for at least 15 minutes; seek medical attention if irritation persists

Ingestion: Rinse mouth; seek immediate medical attention

 

Firefighting Measures
Fire Hazards: Combustible under fire conditions

Extinguishing Media: Water spray, foam, dry chemical, or CO₂

Special Precautions: Use self-contained breathing apparatus

Hazardous Combustion Products: Carbon oxides and toxic fumes

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