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Vitamin B1 (Thiamine HCL)
Vitamin B1 Thiamine HCL is a water-soluble, stable salt form of vitamin B1 used widely in pharmaceuticals, nutraceuticals, and food fortification. It plays a critical role in energy metabolism by aiding carbohydrate breakdown and supports nervous system health. The hydrochloride form offers enhanced stability and solubility, making it suitable for oral supplements, injectables, and fortified foods.
Vitamin B1 (Thiamine HCL)
Primary Uses
- Pharmaceutical Industry
- Nutritional Supplement: Used in tablets, capsules, and injections to prevent or treat thiamine deficiency and related neurological disorders such as beriberi and Wernicke-Korsakoff syndrome.
- Metabolic Support: Included in formulations aimed at improving energy metabolism and nervous system function.
- Food & Beverage Industry
- Fortification Agent: Added to cereals, flours, and beverages to enhance nutritional content and prevent vitamin B1 deficiency.
- Nutraceuticals & Dietary Supplements
- Used in multivitamin and B-complex supplements to support overall health, energy production, and neurological function.
Secondary Uses
- Animal Nutrition
- Feed Additive: Supplemented in animal feed to promote growth, appetite, and nervous system health in livestock and pets.
- Cosmetics
- Skin Health: Occasionally utilized in topical formulations for its antioxidant properties and skin nourishment.
- Research & Development
- Used in biochemical research focusing on thiamine metabolism, deficiency, and supplementation.
1. Basic Identification Attributes
- Chemical Name (IUPAC): 3-[(4-Amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methylthiazolium chloride
- Common/Trade Name: Thiamine Hydrochloride, Vitamin B1 HCL
- CAS Number: 67-03-8
- HS Code: 2936.21.00
- Synonyms: Thiamine HCl, vitamin B1 hydrochloride
2. Physical & Chemical Properties
- Physical State: White or off-white crystalline powder
- Color & Odor: White to off-white; odorless or faint characteristic odor
- Solubility: Highly soluble in water; slightly soluble in alcohol
- Melting Point: 248-252 °C (decomposes)
- Density: Approx. 1.3 g/cm³
3. Safety & Hazard Attributes
- GHS Classification: Not classified as hazardous under normal use
- Toxicity: Low toxicity within recommended dosages
- Exposure Limits: No specific occupational exposure limits established
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry, and well-ventilated area away from light and moisture
- Container Type: Sealed, moisture-proof containers or bags
- Shelf Life: 24 months under proper storage conditions
- Handling Precautions: Avoid dust formation; use personal protective equipment as needed
5. Regulatory & Compliance Attributes
- Complies with USP, BP, and other relevant pharmacopeia standards
- Manufactured under GMP to ensure consistent quality and safety
- Approved for use in food fortification, dietary supplements, and pharmaceuticals
- Meets international regulatory requirements for vitamin B1 products
6. Environmental & Health Impact
- Biodegradability: Biodegradable under normal environmental conditions
- Ecotoxicity: Low environmental risk
- Bioaccumulation: Not significant
Safety Handling Precautions
- PPE Required: Gloves and dust mask recommended during handling
- Handling Guidelines: Use in well-ventilated areas to minimize dust exposure
- Storage Measures: Keep containers tightly closed and dry
First Aid Measures
- Inhalation: Move to fresh air; seek medical advice if symptoms persist
- Skin Contact: Wash with soap and water
- Eye Contact: Flush with water for 15 minutes; seek medical attention if irritation continues
- Ingestion: Rinse mouth; seek medical advice if large amounts ingested
Firefighting Measures
- Fire Hazards: Combustible but not highly flammable
- Extinguishing Media: Use water spray, foam, or dry chemical extinguishers
- Hazardous Combustion Products: May produce carbon oxides and nitrogen oxides upon burning
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