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Vitamin D3
Vitamin D3 BP, also known as Cholecalciferol, is a fat-soluble vitamin primarily responsible for regulating calcium and phosphate metabolism in the body. It is synthesized in the skin through sunlight exposure or obtained from dietary sources and supplements. The BP (British Pharmacopoeia) grade ensures pharmaceutical quality and purity. Vitamin D3 is used in a wide range of applications, including human and veterinary medicine, supplements, fortified foods, cosmetics, and animal nutrition.
Vitamin D3
Primary Uses
- Pharmaceutical Industry
- Therapeutic Supplement: Used in oral tablets, soft gels, and injectables to prevent and treat vitamin D3 deficiency, rickets, osteomalacia, and hypocalcemia.
- Bone Health Formulations: Included in calcium-D3 combinations for treating osteoporosis and maintaining bone density.
- Hormonal Regulation: Used in treatments affecting parathyroid hormone levels and calcium metabolism.
- Nutraceuticals & Dietary Supplements
- General Wellness: Common in multivitamin and immune-boosting supplements for its role in bone, muscle, and immune health.
- Sports & Active Nutrition: Added to products aimed at enhancing muscle function and recovery in athletes.
- Food & Beverage Industry
- Food Fortification: Enriched in dairy products, cereals, margarine, plant-based milk, and infant formula to combat widespread vitamin D deficiency.
Secondary Uses
- Veterinary Medicine
- Animal Supplementation: Used in formulations to prevent rickets, bone deformities, and reproductive issues in livestock, poultry, and pets.
- Feed Fortification: Added to compound feed premixes to support growth, bone strength, and calcium utilization.
- Cosmetics & Personal Care
- Skin Health: Occasionally included in skin creams and lotions for its anti-inflammatory properties and role in supporting skin barrier function.
- Anti-Aging Products: Used in niche formulations targeting mature or vitamin D-deficient skin.
- Clinical & Hospital Use
- Parenteral Nutrition: Administered to patients on total parenteral nutrition (TPN) or those with malabsorption syndromes.
- Research & Laboratory Use
- Endocrinology Studies: Used in clinical and academic research for studying calcium-phosphate homeostasis and vitamin D metabolism.
- Cell Culture: Employed in vitro for testing cell differentiation, proliferation, and receptor activity.
1. Basic Identification Attributes
- Chemical Name (IUPAC): (3β,5Z,7E)-9,10-secocholesta-5,7,10(19)-trien-3-ol
- Common/Trade Name: Vitamin D3, Cholecalciferol
- CAS Number: 67-97-0
- HS Code: 2936.29.00
- Synonyms: Cholecalciferol, Colecalciferol, Calciol
2. Physical & Chemical Properties
- Physical State: Oily liquid or crystalline solid (depending on concentration/form)
- Color & Odor: White to off-white (solid); faint odor
- Solubility: Insoluble in water; soluble in fats, oils, and alcohol
- Melting Point: 83–85 °C (for solid forms)
- Molecular Formula: C27H44O
- Molecular Weight: 384.64 g/mol
- Stability: Sensitive to light, air, and heat; requires stabilized formulations
3. Safety & Hazard Attributes
- GHS Classification: May cause damage to organs through prolonged or repeated exposure at high doses
- Toxicity: Low at nutritional doses; toxic in excess (hypervitaminosis D)
- Exposure Limits: No occupational exposure limit, but intake should follow regulatory guidelines
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place protected from light and oxygen
- Container Type: Amber glass bottles or nitrogen-flushed drums
- Shelf Life: 24–36 months when stored properly
- Handling Precautions: Avoid direct contact and exposure to air and light; handle under inert conditions if necessary
5. Regulatory & Compliance Attributes
- Complies with: BP, USP, EP, and FCC specifications
- Manufactured under: GMP and ISO-certified processes
- Approved in: Human and veterinary pharmaceuticals, dietary supplements, food fortification
- Meets Requirements for: WHO, Codex Alimentarius, EFSA, FDA, and other global regulatory authorities
6. Environmental & Health Impact
- Biodegradability: Expected to degrade under environmental conditions
- Ecotoxicity: Low in typical use concentrations
- Bioaccumulation: Not expected to bioaccumulate significantly
Safety Handling Precautions
- PPE Required: Gloves, safety goggles, and lab coat recommended
- Handling Guidelines: Minimize exposure to light, oxygen, and heat; avoid inhalation of powders (in concentrated premix)
- Storage Measures: Use light-resistant and airtight containers; refrigerate if required
First Aid Measures
- Inhalation: Remove to fresh air; seek medical attention if respiratory symptoms occur
- Skin Contact: Wash with soap and water
- Eye Contact: Rinse thoroughly with water for at least 15 minutes
- Ingestion: Rinse mouth; seek medical attention if large quantities ingested
Firefighting Measures
- Fire Hazards: Combustible at high temperatures
- Extinguishing Media: Use water spray, dry chemical, or CO₂
- Hazardous Combustion Products: May emit carbon oxides under fire conditions
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