Vitamin E Acetate (DL-Alpha-Tocopheryl Acetate)

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Vitamin E Acetate (DL-Alpha-Tocopheryl Acetate), chemically known as DL-Alpha-Tocopheryl Acetate, is a stable, synthetic form of Vitamin E used widely in pharmaceuticals, cosmetics, food fortification, and dietary supplements. As an esterified form of tocopherol, it offers superior oxidative stability, making it ideal for formulations requiring extended shelf life. It functions as a potent antioxidant, protecting cells from oxidative damage and supporting immune and skin health.

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Categories: Antioxidants, Nutrient Supplements Tags: Antioxidant Vitamin, DL-Alpha-Tocopheryl Acetate, Fat-Soluble Vitamin, Food & Beverage Industry, Nutraceuticals, Pharmaceuticals, Vitamin E Acetate

Description

Table of Contents

Vitamin E Acetate (DL-Alpha-Tocopheryl Acetate)

Primary Uses

Pharmaceutical Industry

Vitamin Supplementation: Used in tablets, capsules, syrups, and injectable forms for treating or preventing Vitamin E deficiency.
Therapeutic Use: Applied in therapies for neurological disorders, muscle degeneration, and cardiovascular health due to its antioxidant properties.
Parenteral Nutrition: Included in IV formulations for critically ill patients who require essential nutrients.

Nutraceuticals & Dietary Supplements

Antioxidant Formulations: Incorporated in health supplements to combat oxidative stress and aging.
Immune Support: Used in multivitamins and immune-boosting supplements.
Skin, Hair, and Nail Supplements: Popular in beauty supplements to promote skin elasticity and hair strength.

Cosmetics & Personal Care

Skin Care Products: Found in creams, lotions, and serums for its moisturizing and anti-aging properties. It protects skin from UV damage and supports healing.
Hair Care: Added to conditioners and oils for promoting scalp health and reducing oxidative damage.
Sun Care: Frequently used in sunscreens due to its protective effects against UV-induced damage.

Food & Beverage Industry

Food Fortification: Used as a nutrient additive in margarine, cereals, dairy products, and infant formula.
Preservative: Acts as a natural antioxidant to extend shelf life of fat-containing foods by preventing rancidity.

Secondary Uses

Veterinary Medicine

Animal Supplements: Added to livestock and pet supplements to support immune health, reproduction, and growth.
Topical Animal Products: Used in skin formulations for veterinary dermatological use.

Industrial Applications

Polymer Additives: Sometimes used in plastic manufacturing as an antioxidant to protect against degradation.
Stabilizer in Medical Devices: Helps preserve sensitive compounds or surfaces during storage.

Research & Biotechnology

Oxidative Stress Studies: Used in lab settings to study antioxidant mechanisms and cellular aging.
Formulation Development: Used in stability testing of fat-soluble ingredients.

KEY PRODUCT FEATURES

1. Basic Identification Attributes

Chemical Name (IUPAC): (±)-2,5,7,8-Tetramethyl-2-[(4,8,12-trimethyltridecyl)oxy]chroman-6-yl acetate
Common/Trade Name: Vitamin E Acetate, DL-Alpha-Tocopheryl Acetate
CAS Number: 7695-91-2
HS Code: 2936.28.00
Synonyms: Tocopherol Acetate, All-rac-alpha-tocopheryl acetate

2. Physical & Chemical Properties

Physical State: Clear, viscous oil
Color & Odor: Pale yellow to amber; mild characteristic odor
Solubility: Insoluble in water; soluble in fats, oils, ethanol
Boiling Point: >200 °C (decomposes)
Molecular Formula: C31H52O3
Molecular Weight: 472.75 g/mol
Stability: Excellent stability in presence of air and light compared to free tocopherol

3. Safety & Hazard Attributes

GHS Classification: Not classified as hazardous
Toxicity: Low toxicity; generally safe in regulated doses
Exposure Limits: No occupational exposure limits established
Overdose Risks: Excessive intake may cause bleeding or gastrointestinal issues

4. Storage & Handling Attributes

Storage Conditions: Store in a cool, dry place protected from heat, light, and air
Container Type: Amber glass or metal drums under nitrogen atmosphere
Shelf Life: 24–36 months when properly stored
Handling Precautions: Avoid prolonged exposure to air and light; use under controlled conditions

5. Regulatory & Compliance Attributes

Complies with: USP, BP, EP, FCC standards
Manufactured under: GMP and ISO-certified facilities
GRAS Status: Recognized as safe for use in foods and supplements
Approved by: FDA, EFSA, WHO for food, drug, and cosmetic use

6. Environmental & Health Impact

Biodegradability: Readily biodegradable
Ecotoxicity: Not expected to pose significant environmental risk
Bioaccumulation: Low potential for bioaccumulation

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE Required: Gloves, goggles, and lab coat recommended
Handling Guidelines: Avoid contact with eyes and prolonged skin contact
Storage Measures: Keep sealed and away from oxidative conditions

First Aid Measures

Inhalation: Not a typical route of exposure; move to fresh air if irritation occurs
Skin Contact: Wash with soap and water
Eye Contact: Rinse immediately with plenty of water for at least 15 minutes
Ingestion: Generally safe; seek medical attention if large amounts are consumed

Firefighting Measures

Fire Hazards: Combustible under high heat
Extinguishing Media: Use foam, dry chemical, CO₂, or water spray
Hazardous Combustion Products: Carbon monoxide, carbon dioxide, and potential irritant fumes