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Vitamin E Acetate (DL-Alpha-Tocopheryl Acetate)
Vitamin E Acetate (DL-Alpha-Tocopheryl Acetate), chemically known as DL-Alpha-Tocopheryl Acetate, is a stable, synthetic form of Vitamin E used widely in pharmaceuticals, cosmetics, food fortification, and dietary supplements. As an esterified form of tocopherol, it offers superior oxidative stability, making it ideal for formulations requiring extended shelf life. It functions as a potent antioxidant, protecting cells from oxidative damage and supporting immune and skin health.
Vitamin E Acetate (DL-Alpha-Tocopheryl Acetate)
Primary Uses
- Pharmaceutical Industry
- Vitamin Supplementation: Used in tablets, capsules, syrups, and injectable forms for treating or preventing Vitamin E deficiency.
- Therapeutic Use: Applied in therapies for neurological disorders, muscle degeneration, and cardiovascular health due to its antioxidant properties.
- Parenteral Nutrition: Included in IV formulations for critically ill patients who require essential nutrients.
- Nutraceuticals & Dietary Supplements
- Antioxidant Formulations: Incorporated in health supplements to combat oxidative stress and aging.
- Immune Support: Used in multivitamins and immune-boosting supplements.
- Skin, Hair, and Nail Supplements: Popular in beauty supplements to promote skin elasticity and hair strength.
- Cosmetics & Personal Care
- Skin Care Products: Found in creams, lotions, and serums for its moisturizing and anti-aging properties. It protects skin from UV damage and supports healing.
- Hair Care: Added to conditioners and oils for promoting scalp health and reducing oxidative damage.
- Sun Care: Frequently used in sunscreens due to its protective effects against UV-induced damage.
- Food & Beverage Industry
- Food Fortification: Used as a nutrient additive in margarine, cereals, dairy products, and infant formula.
- Preservative: Acts as a natural antioxidant to extend shelf life of fat-containing foods by preventing rancidity.
Secondary Uses
- Veterinary Medicine
- Animal Supplements: Added to livestock and pet supplements to support immune health, reproduction, and growth.
- Topical Animal Products: Used in skin formulations for veterinary dermatological use.
- Industrial Applications
- Polymer Additives: Sometimes used in plastic manufacturing as an antioxidant to protect against degradation.
- Stabilizer in Medical Devices: Helps preserve sensitive compounds or surfaces during storage.
- Research & Biotechnology
- Oxidative Stress Studies: Used in lab settings to study antioxidant mechanisms and cellular aging.
- Formulation Development: Used in stability testing of fat-soluble ingredients.
1. Basic Identification Attributes
- Chemical Name (IUPAC): (±)-2,5,7,8-Tetramethyl-2-[(4,8,12-trimethyltridecyl)oxy]chroman-6-yl acetate
- Common/Trade Name: Vitamin E Acetate, DL-Alpha-Tocopheryl Acetate
- CAS Number: 7695-91-2
- HS Code: 2936.28.00
- Synonyms: Tocopherol Acetate, All-rac-alpha-tocopheryl acetate
2. Physical & Chemical Properties
- Physical State: Clear, viscous oil
- Color & Odor: Pale yellow to amber; mild characteristic odor
- Solubility: Insoluble in water; soluble in fats, oils, ethanol
- Boiling Point: >200 °C (decomposes)
- Molecular Formula: C31H52O3
- Molecular Weight: 472.75 g/mol
- Stability: Excellent stability in presence of air and light compared to free tocopherol
3. Safety & Hazard Attributes
- GHS Classification: Not classified as hazardous
- Toxicity: Low toxicity; generally safe in regulated doses
- Exposure Limits: No occupational exposure limits established
- Overdose Risks: Excessive intake may cause bleeding or gastrointestinal issues
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry place protected from heat, light, and air
- Container Type: Amber glass or metal drums under nitrogen atmosphere
- Shelf Life: 24–36 months when properly stored
- Handling Precautions: Avoid prolonged exposure to air and light; use under controlled conditions
5. Regulatory & Compliance Attributes
- Complies with: USP, BP, EP, FCC standards
- Manufactured under: GMP and ISO-certified facilities
- GRAS Status: Recognized as safe for use in foods and supplements
- Approved by: FDA, EFSA, WHO for food, drug, and cosmetic use
6. Environmental & Health Impact
- Biodegradability: Readily biodegradable
- Ecotoxicity: Not expected to pose significant environmental risk
- Bioaccumulation: Low potential for bioaccumulation
Safety Handling Precautions
- PPE Required: Gloves, goggles, and lab coat recommended
- Handling Guidelines: Avoid contact with eyes and prolonged skin contact
- Storage Measures: Keep sealed and away from oxidative conditions
First Aid Measures
- Inhalation: Not a typical route of exposure; move to fresh air if irritation occurs
- Skin Contact: Wash with soap and water
- Eye Contact: Rinse immediately with plenty of water for at least 15 minutes
- Ingestion: Generally safe; seek medical attention if large amounts are consumed
Firefighting Measures
- Fire Hazards: Combustible under high heat
- Extinguishing Media: Use foam, dry chemical, COâ‚‚, or water spray
- Hazardous Combustion Products: Carbon monoxide, carbon dioxide, and potential irritant fumes
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