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L-Glutathione Reduced

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L-Glutathione Reduced is a tripeptide composed of glutamine, cysteine, and glycine, present in cells as a vital antioxidant. It appears as a white to off-white crystalline powder and plays a key role in protecting cells from oxidative stress by neutralizing free radicals and reactive oxygen species. Reduced glutathione (GSH) is the active form that participates in cellular detoxification, immune support, and regeneration of other antioxidants. It is widely used in pharmaceutical, cosmetic, and food industries due to its potent antioxidant properties and skin-brightening effects.

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Categories: Antioxidants(cosmetic), Antioxidants, Excipients, Nutraceutical Ingredients (food), Nutraceutical Ingredients (pharmaceutical) Tags: Antioxidant Supplement, Cosmetics & Personal Care, Functional Foods, L-Glutathione Reduced, Nutraceutical Ingredients, Pharmaceutical excipients, Reduced Glutathione

Description

Table of Contents

L-Glutathione Reduced

Primary Uses

Pharmaceutical Industry

Antioxidant Supplement: Used in oral and injectable formulations to support detoxification in liver diseases, protect against oxidative damage, and improve immune function.
Therapeutic Agent: Employed in treatments for conditions like Parkinson’s disease, cystic fibrosis, and certain cancers due to its role in cellular protection and regeneration.

Cosmetic Industry

Skin Whitening Agent: Incorporated in creams, serums, and lotions to reduce melanin synthesis and promote even skin tone by inhibiting tyrosinase enzyme activity.
Anti-Aging: Helps combat oxidative stress in skin cells, improving skin elasticity and reducing wrinkles.
Detoxification: Aids in removing toxins from skin cells, enhancing overall skin health and radiance.

Food and Nutraceuticals

Dietary Supplement: Added to health supplements to boost the body’s antioxidant defenses and support overall wellness.
Food Additive: Used as a preservative to prevent oxidation and extend shelf life of sensitive food products.

Secondary Uses

Biotechnology and Research

Cell Culture: Used as a supplement in cell culture media to maintain cellular redox balance and improve cell viability.
Diagnostic Kits: Utilized in assays measuring oxidative stress and glutathione levels in biological samples.

Veterinary Medicine

Supplement in animal feeds and treatments to improve immunity and reduce oxidative stress in livestock and pets.

Industrial Applications

Incorporated in anti-corrosion coatings and stabilizers where antioxidant properties help prolong material lifespan.

PRODUCT KEY FEATURES

Basic Identification Attributes

Chemical Name (IUPAC): (2S)-2-Amino-4-{[(1R)-1-[(carboxymethyl)amino]-1-oxopropan-2-yl]amino}-4-oxobutanoic acid
Common/Trade Name: L-Glutathione Reduced; GSH
CAS Number: 70-18-8
HS Code: 2934.99.90
Synonyms: Reduced glutathione; GSH; L-γ-Glutamyl-L-cysteinylglycine

Physical & Chemical Properties

Physical State: Crystalline powder
Color & Odor: White to off-white; odorless or faint sulfur-like smell
Melting Point: ~200 °C (decomposes)
Solubility: Soluble in water; slightly soluble in alcohol
Stability: Sensitive to air, light, and heat; prone to oxidation

Safety & Hazard Attributes

GHS Classification: Not classified as hazardous under normal use
Toxicity: Low toxicity; generally regarded as safe for human consumption and topical use
Exposure Limits: No established occupational exposure limits

Storage & Handling Attributes

Storage Conditions: Store in airtight containers, protected from light and moisture, preferably refrigerated
Container Type: Sealed, opaque containers to minimize oxidation
Shelf Life: Typically 1-2 years under proper storage conditions
Handling Precautions: Avoid prolonged exposure to air and light; handle with gloves to prevent contamination

Regulatory & Compliance Attributes

Approved for use in cosmetics and dietary supplements by FDA and other regulatory agencies
Complies with pharmaceutical grade purity standards when used in medicinal products
Labeling must indicate antioxidant properties and potential allergen information where applicable

Environmental & Health Impact

Biodegradability: Biodegradable and environmentally safe
Ecotoxicity: Low ecotoxicity
Bioaccumulation: Not expected to bioaccumulate
Carcinogenicity/Mutagenicity: Not classified as carcinogenic or mutagenic

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE Required: Gloves recommended during handling to avoid contamination
Handling Guidelines: Use in well-ventilated areas; avoid inhalation of dust
Storage Measures: Keep containers tightly closed, store in cool, dark place

First Aid Measures

Inhalation: Move to fresh air if inhalation causes irritation
Skin Contact: Wash with soap and water if irritation occurs
Eye Contact: Rinse eyes with water for 15 minutes; seek medical attention if irritation persists
Ingestion: Generally safe; seek medical attention if large amounts ingested and adverse effects occur

Firefighting Measures

Fire Hazards: Non-flammable
Extinguishing Media: Use water spray, foam, or dry chemical extinguishers for surrounding fires
Special Precautions: Avoid inhaling combustion products
Hazardous Combustion Products: May produce carbon oxides and sulfur-containing compounds