Naphazolin hCL USP

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Naphazolin Hydrochloride (Naphazolin HCL) is a topical sympathomimetic agent commonly used as a nasal decongestant and ophthalmic vasoconstrictor. It is a white to off-white crystalline powder soluble in water and alcohol. Naphazolin HCL works by constricting blood vessels, reducing swelling and redness in mucous membranes and eyes. It is widely used in pharmaceutical formulations such as nasal sprays and eye drops.

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Categories: Active Pharmaceutical Ingredients (APIs), Biochemical Reagents, Excipients, LABORATORY CHEMICALS, PHARMACEUTICAL CHEMICALS Tags: API Suppliers, High Purity API, Naphazoline HCL USP, Naphazoline Hydrochloride, Pharmaceutical industry, White crystalline powder

Description

Table of Contents

Primary Uses

Nasal Decongestant
- Used in nasal sprays and drops to relieve nasal congestion caused by colds, allergies, sinusitis, and other upper respiratory tract infections.
- Effective in reducing nasal mucosa swelling and improving airflow by vasoconstriction.
- Commonly found in over-the-counter and prescription nasal decongestant products.
Ophthalmic Vasoconstrictor
- Used in eye drops to relieve redness caused by minor eye irritations, allergies, conjunctivitis, and dryness.
- Provides temporary relief by constricting conjunctival blood vessels, reducing eye redness and swelling.
- Utilized in pre- and post-operative eye care to reduce ocular congestion.

Secondary Uses

Combination Pharmaceutical Products
- Incorporated with antihistamines, analgesics, or corticosteroids to provide combined relief of allergy symptoms or eye conditions.
Veterinary Applications
- Used in veterinary ophthalmic and nasal preparations for similar vasoconstrictive effects in animals.
Emergency Medical Use
- Occasionally used in emergency nasal or ocular care to quickly reduce swelling and improve breathing or vision clarity.
Research and Diagnostic Use
- Used in laboratories and research for studies involving vasoconstriction and drug efficacy related to mucous membranes and ocular tissues.
Adjunct in Treatment of Allergic Rhinitis

Used as supportive therapy to alleviate nasal congestion associated with allergic rhinitis.

KEY PRODUCT FEATURES

Basic Identification Attributes

Chemical Name (IUPAC): 2-(1-Naphthyl)-N,N-dimethyl-2-imidazoline hydrochloride
Common/Trade Name: Naphazolin HCL, Naphazoline Hydrochloride
CAS Number: 147-69-7
HS Code: 2933.99.90
Synonyms: Naphazoline hydrochloride; Naphazoline HCl

Physical & Chemical Properties

Physical State: White to off-white crystalline powder
Color & Odor: White; odorless
Solubility: Freely soluble in water and alcohol
Melting Point: 170–175°C (decomposes)
pH (1% aqueous solution): Approximately 4.5–5.5

Safety & Hazard Attributes

GHS Classification: Not classified as hazardous under normal pharmaceutical use
Toxicity: Low toxicity at therapeutic doses; overdose can cause systemic effects
Exposure Limits: N/A for pharmaceutical-grade product

Storage & Handling Attributes

Storage Conditions: Store in a cool, dry place protected from light
Container Type: Supplied in airtight containers or pharmaceutical packaging
Shelf Life: Typically 2–3 years if stored properly
Handling Precautions: Avoid inhalation of powder and contact with eyes (undiluted)

Regulatory & Compliance Attributes

Complies with USP (United States Pharmacopeia) standards
Registered under relevant pharmaceutical regulatory authorities (FDA, EMA, etc.)

Environmental & Health Impact

Biodegradability: Data not applicable due to pharmaceutical use
Ecotoxicity: Low risk due to controlled medical use
Bioaccumulation: Not applicable

Carcinogenicity/Mutagenicity: Not classified as carcinogenic

SAFETY HANDLING PRECAUTIONS

Safety Handling Precautions

PPE Required: Gloves recommended during handling of raw powder
Handling Guidelines: Avoid dust generation; handle in well-ventilated area
Storage Measures: Keep container tightly closed; protect from moisture and light

First Aid Measures

Inhalation: Move to fresh air; seek medical attention if symptoms develop
Skin Contact: Wash with soap and water; seek medical advice if irritation occurs
Eye Contact: Rinse thoroughly with water; seek medical attention if irritation persists
Ingestion: Seek immediate medical attention; do not induce vomiting unless directed

Firefighting Measures

Fire Hazards: Not highly flammable but combustible
Extinguishing Media: Use water spray, foam, dry chemical, or CO₂
Special Precautions: Wear protective equipment to avoid inhalation of dust
Hazardous Combustion Products: May produce nitrogen oxides and other toxic fumes