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PVP K 30 USP
PVP K 30 USP (Polyvinylpyrrolidone K-30) is a water-soluble polymer widely used in pharmaceutical and cosmetic formulations. It serves as a binder, stabilizer, and film-forming agent, known for its excellent adhesive properties and compatibility with a wide range of ingredients. PVP K 30 USP is characterized by its medium molecular weight, making it ideal for tablet binding, enhancing solubility of poorly soluble drugs, and providing viscosity control in liquid formulations. This grade complies with USP standards ensuring suitability for pharmaceutical use.
PVP K 30 USP
Primary Uses
- Pharmaceutical Industry
- Used as a binder in tablet and capsule formulations to improve mechanical strength and cohesion of powders.
- Acts as a solubilizing agent to enhance bioavailability of poorly water-soluble drugs.
- Employed as a suspending agent in oral suspensions and syrups.
- Functions as a film former in controlled-release and coating formulations.
- Cosmetics and Personal Care
- Used as a thickener and stabilizer in lotions, creams, shampoos, and hair sprays.
- Acts as a film-forming agent in hair styling products and facial masks.
- Enhances moisture retention and skin feel in topical formulations.
- Food Industry
- Utilized as a stabilizer and emulsifier in certain food products under regulatory approval.
Secondary Uses
- Industrial Applications
- Used as a protective colloid and dispersant in adhesives, inks, and paints.
- Employed in the formulation of photographic chemicals.
- Laboratory Uses
- Acts as a matrix and stabilizer in biochemical and molecular biology applications.
1. Basic Identification Attributes
- Chemical Name (IUPAC): Poly(1-vinyl-2-pyrrolidone)
- Common/Trade Name: PVP K 30 USP
- CAS Number: 9003-39-8
- HS Code: 3906.90.10
- Synonyms: Polyvinylpyrrolidone K-30; Povidone K30
2. Physical & Chemical Properties
- Physical State: Fine white to off-white powder
- Solubility: Soluble in water and some polar solvents
- Molecular Weight: Approximately 40,000 Da (K value 30)
- pH (1% solution): 4.0 – 7.0
- Odor & Color: Odorless or slight characteristic odor; white powder
3. Safety & Hazard Attributes
- GHS Classification: Not classified as hazardous
- Toxicity: Low toxicity; non-irritant under normal use
- Exposure Limits: Follow occupational safety standards for dust control
4. Storage & Handling Attributes
- Storage Conditions: Store in a cool, dry, well-ventilated area away from incompatible substances
- Container Type: Supplied in sealed bags or drums
- Shelf Life: 2–3 years if stored properly
- Handling Precautions: Avoid dust generation; use protective masks and gloves when handling powder
5. Regulatory & Compliance Attributes
- Complies with USP monograph for Polyvinylpyrrolidone
- Generally Recognized As Safe (GRAS) for specified uses
- Manufactured in GMP-certified facilities
6. Environmental & Health Impact
- Biodegradability: Readily biodegradable under aerobic conditions
- Ecotoxicity: Low toxicity to aquatic organisms
- Bioaccumulation: Not significant
Safety Handling Precautions
- PPE Required: Dust mask, gloves, and eye protection recommended
- Handling Guidelines: Use in well-ventilated areas; minimize dust exposure
- Storage Measures: Keep containers tightly closed and stored in a dry environment away from moisture
First Aid Measures
- Inhalation: Move to fresh air; seek medical attention if respiratory discomfort occurs
- Skin Contact: Wash with soap and water; seek medical advice if irritation develops
- Eye Contact: Rinse with plenty of water for at least 15 minutes; seek medical attention if irritation persists
- Ingestion: Rinse mouth; seek medical advice if large quantities are ingested
Firefighting Measures
- Fire Hazards: Combustible dust may form explosive mixtures in air
- Extinguishing Media: Use water spray, foam, dry chemical, or CO₂
- Special Precautions: Avoid dust accumulation; use respiratory protection and protective clothing
- Hazardous Combustion Products: Carbon oxides, nitrogen oxides
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