Sucralose
Sucralose is a high-intensity, zero-calorie artificial sweetener derived from sucrose through selective chlorination. It is approximately 600 times sweeter than sugar, making it an effective sugar substitute in a wide range of food and beverage applications. Sucralose is stable under heat and across a broad pH range, suitable for cooking, baking, and long shelf-life products. It delivers sweetness without calories or glycemic impact, favored in health-conscious and diabetic-friendly formulations.
Primary Uses
Food & Beverage Industry
Tabletop Sweeteners: Used in granular or powder form as a sugar substitute in beverages, coffee, and tea.
Baked Goods: Stable under baking conditions, used in cakes, cookies, and pastries.
Dairy Products: Added to yogurts, ice creams, and flavored milks for sweetness without added calories.
Beverages: Used in soft drinks, diet sodas, juices, and energy drinks for low-calorie sweetness.
Confectionery: Employed in chewing gums, candies, and chocolates.
Pharmaceuticals & Nutraceuticals
Oral Care Products: Added to toothpaste and mouthwashes for sweetening without promoting tooth decay.
Medications: Used to mask bitterness in syrups, chewable tablets, and oral solutions.
Dietary Supplements: Included in formulations targeting weight management and diabetic consumers.
Secondary Uses
Cosmetics & Personal Care
Flavor Enhancer: Added to lip balms, lipsticks, and flavored skincare products.
Animal Feed
Palatability Enhancer: Occasionally used to improve taste in specialized feed formulations.
Industrial Applications
Chemical Intermediate: Used in research and development for sweetener-related chemical synthesis.
Basic Identification Attributes
Chemical Name (IUPAC): 1,6-Dichloro-1,6-dideoxy-β-D-fructofuranosyl-4-chloro-4-deoxy-α-D-galactopyranoside
Common/Trade Name: Sucralose
CAS Number: 56038-13-2
HS Code: 2932.90.90
Synonyms: Splenda (brand), Trichlorogalactosucrose
Physical & Chemical Properties
Physical State: White crystalline powder
Color & Odor: White; odorless
Melting Point: 125–130 °C (decomposes)
Solubility: Highly soluble in water; insoluble in ethanol and other organic solvents
Density: Approx. 1.4 g/cm³
Stability: Stable under heat, acid, and alkaline conditions
Safety & Hazard Attributes
GHS Classification: Not classified as hazardous
Toxicity: Low toxicity; Generally Recognized as Safe (GRAS) by FDA
Exposure Limits: No established occupational exposure limits
Storage & Handling Attributes
Storage Conditions: Store in a cool, dry place, away from moisture and direct sunlight
Container Type: Sealed bags, drums, or containers with moisture barriers
Shelf Life: 24–36 months when stored properly
Handling Precautions: Avoid dust formation; use dust extraction if necessary
Regulatory & Compliance Attributes
Approved by FDA, EFSA, JECFA, and other international food safety authorities.
Complies with Codex Alimentarius standards for food additives.
Meets ISO 9001 and GMP standards for quality and safety.
Listed under TSCA and complies with REACH regulations.
Environmental & Health Impact
Biodegradability: Poorly biodegradable but considered environmentally safe at typical use levels.
Ecotoxicity: Low toxicity to aquatic organisms at environmental concentrations.
Bioaccumulation: Not significant.
PPE Required: Gloves and dust mask recommended during handling
Handling Guidelines: Use adequate ventilation to avoid dust inhalation
Storage Measures: Keep containers tightly sealed and dry
First Aid Measures
Inhalation: Remove to fresh air; seek medical attention if irritation occurs
Skin Contact: Wash with soap and water
Eye Contact: Flush with water for 15 minutes; seek medical help if irritation persists
Ingestion: Rinse mouth; seek medical advice if large amounts ingested
Firefighting Measures
Fire Hazards: Combustible organic powder
Extinguishing Media: Use water spray, foam, dry chemical, or CO₂ extinguishers
Hazardous Combustion Products: Carbon oxides and hydrogen chloride gas
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This white to off-white crystalline powder is highly effective and exhibits broad-spectrum antifungal and some antibacterial activity. It is commonly utilized in creams, ointments, powders, and gel formulations.

Preservatives(food)
Flavor Enhancers
Acidulants
Sweeteners
Antioxidants
Colorants(food)
Nutraceutical Ingredients (food)
Nutrient Supplements
Emulsifiers
Collectors
Dust Suppressants
Explosives and Blasting Agents
Flocculants and Coagulants
Frothers
Leaching Agents
pH Modifiers
Precious Metal Extraction Agents
Antioxidants(plastic)
Colorants (Pigments, Dyes)
Fillers and Reinforcements
Flame Retardants
Monomers
Plasticizers
Polymerization Initiators
Stabilizers (UV, Heat)
Antifoaming Agents
Chelating Agents
Coagulants and Flocculants
Corrosion Inhibitors
Disinfectants and Biocides
Oxidizing Agents
pH Adjusters
Scale Inhibitors( water)
Antioxidants(cosmetic)
Emollients
Fragrances and Essential Oils
Humectants
Preservatives
Surfactants(cosmetic)
Thickeners
UV Filters
Fertilizers
Soil Conditioners
Plant Growth Regulators
Animal Feed Additives
Biostimulants
Pesticides (Herbicides, Insecticides, Fungicides)
Active Pharmaceutical Ingredients (APIs)
Excipients
Solvents(pharmaceutical)
Antibiotics
Antiseptics and Disinfectants
Vaccine Adjuvants
Nutraceutical Ingredients (pharmaceutical)
Analgesics & Antipyretics
Analytical Reagents
Solvents(lab)
Chromatography Chemicals
Spectroscopy Reagents
microbiology-and-cell-culture-reagents
Molecular Biology Reagents
Biochemical Reagents
Inorganic and Organic Standards
Laboratory Safety Chemicals
Specialty Laboratory Chemicals(Special Laboratory Equipment)
Demulsifiers
Hydraulic Fracturing Fluids
Scale Inhibitors(oil)
Surfactants(oil)
Drilling Fluids
Dyes and Pigments
Bleaching Agents
Softening Agents
Finishing Agents
Antistatic Agents
Admixtures
Waterproofing Agents
Sealants and Adhesives
Curing Compounds
Concrete Repair Chemicals
Anti-Corrosion Coatings
Surfactants(cleaning)
Builders
Enzymes
Solvents (Cleaning)
Fragrances
Electronic Chemicals
Catalysts
Lubricants
Photographic Chemicals
Refrigerants
Automotive chemicals
Pyrotechnic Chemicals
Biodegradable Surfactants
Bio-based Solvents
Renewable Polymers
Carbon Capture Chemicals
Wastewater Treatment Chemicals
Pigments
Solvents(paint)
Specialty Coatings
Binders/Resins
Additives
Driers
Anti-Corrosion Agents
Functional Coatings
Application-Specific Coatings
Fresh Herbs
Ground Spices
Whole Spices
Spice Blends
Dried Herbs
Leavening Agents
Dough Conditioners
Flour Treatments
Fat Replacers
Decoratives
Preservatives(baking)
Plasticizers & Softeners
Reinforcing Agents
Adhesion Promoters
Vulcanizing Agents
Antidegradants
Blowing Agents
Fillers & Extenders
Accelerators & Retarders